1WVJ

Exploring the GluR2 ligand-binding core in complex with the bicyclic AMPA analogue (S)-4-AHCP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 2001

Chain	Residue
A	LYS60
A	ALA63
A	ASN72
A	SER140
A	HOH3119
A	HOH3124

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 2002

Chain	Residue
A	HOH3043
A	HOH3291
A	TYR80
A	LYS116
A	LYS185

---

site_id	AC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE IBC A 1001

Chain	Residue
A	GLU13
A	TYR61
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	GLY141
A	SER142
A	THR143
A	THR174
A	LEU192
A	GLU193
A	MET196
A	TYR220
A	HOH3004
A	HOH3005

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 3001

Chain	Residue
A	SER108
A	LEU109
A	GLY110
A	SER194
A	THR195
A	GLU198
A	LYS210
A	ASN214
A	HOH3293

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 3002

Chain	Residue
A	TRP71
A	VAL79
A	GLY118
A	HOH3072
A	HOH3094
A	HOH3259

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 3003

Chain	Residue
A	HIS46
A	ARG172
A	LYS240
A	GLN244
A	HOH3267

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
A	PRO89
A	THR91
A	ARG96
A	SER142
A	THR143
A	GLU193

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG64
A	ARG148
A	LYS240

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE121

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER150

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER184

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3

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