1WVF
p-Cresol Methylhydroxylase: Alteration of the Structure of the Flavoprotein Subunit upon its Binding to the Cytochrome Subunit
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004458 | molecular_function | D-lactate dehydrogenase (cytochrome) activity |
| A | 0008720 | molecular_function | D-lactate dehydrogenase (NAD+) activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0018695 | molecular_function | 4-cresol dehydrogenase (hydroxylating) activity |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0071949 | molecular_function | FAD binding |
| A | 1903457 | biological_process | lactate catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 1703 |
| Chain | Residue |
| A | MET48 |
| A | GLY94 |
| A | GLY96 |
| A | SER97 |
| site_id | AC2 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE FAD A 599 |
| Chain | Residue |
| A | ARG91 |
| A | ASN92 |
| A | PHE93 |
| A | SER153 |
| A | ALA154 |
| A | PRO155 |
| A | ALA159 |
| A | GLY160 |
| A | GLY163 |
| A | ASN164 |
| A | GLY169 |
| A | VAL170 |
| A | TYR172 |
| A | CYS231 |
| A | GLU380 |
| A | TYR384 |
| A | TRP394 |
| A | ARG474 |
| A | ARG512 |
| A | ACY1701 |
| A | HOH1709 |
| A | HOH1713 |
| A | HOH1720 |
| A | HOH1755 |
| A | HOH1857 |
| A | TRP85 |
| A | THR86 |
| A | SER88 |
| A | THR89 |
| A | GLY90 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACY A 1701 |
| Chain | Residue |
| A | TYR95 |
| A | TRP394 |
| A | TYR473 |
| A | ARG474 |
| A | FAD599 |
| A | HOH2506 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACY A 1702 |
| Chain | Residue |
| A | ARG91 |
| A | SER156 |
| A | ALA157 |
| A | ILE158 |
| A | LEU378 |
| A | HOH2174 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 1704 |
| Chain | Residue |
| A | ILE116 |
| A | LYS118 |
| A | ILE119 |
| A | HOH2034 |
| A | HOH2076 |
| A | HOH2142 |
| A | HOH2182 |
| A | HOH2240 |
| A | HOH2391 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 1705 |
| Chain | Residue |
| A | VAL51 |
| A | GLU52 |
| A | ARG445 |
| A | HOH1864 |
| A | HOH2146 |
| A | HOH2328 |
| A | HOH2404 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 214 |
| Details | Domain: {"description":"FAD-binding PCMH-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00718","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"O-8alpha-FAD tyrosine"} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1dii |
| Chain | Residue | Details |
| A | TYR473 | |
| A | TYR95 | |
| A | ARG474 | |
| A | GLU380 | |
| A | GLU427 | |
| A | HIS436 |
| site_id | MCSA1 |
| Number of Residues | 10 |
| Details | M-CSA 141 |
| Chain | Residue | Details |
| A | ASP167 | activator, hydrogen bond acceptor |
| A | ARG512 | activator, hydrogen bond donor |
| A | GLU177 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| A | GLU286 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| A | TYR367 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| A | GLU380 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | TYR384 | covalently attached, polar/non-polar interaction, single electron acceptor, single electron donor, single electron relay |
| A | HIS436 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| A | TYR473 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| A | ARG474 | electrostatic stabiliser, hydrogen bond donor |
