1WRL

Crystal structure of the N-terminal domain of human cardiac troponin C in complex with trifluoperazine (monoclinic crystal form)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
B	0005509	molecular_function	calcium ion binding
C	0005509	molecular_function	calcium ion binding
D	0005509	molecular_function	calcium ion binding
E	0005509	molecular_function	calcium ion binding
F	0005509	molecular_function	calcium ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 101

Chain	Residue
A	ASP65
A	ASP67
A	SER69
A	THR71
A	GLU76
A	HOH206

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 102

Chain	Residue
B	THR71
B	GLU76
B	HOH214
B	ASP65
B	ASP67
B	SER69

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 103

Chain	Residue
C	ASP65
C	ASP67
C	SER69
C	THR71
C	GLU76
C	HOH218

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA D 104

Chain	Residue
D	ASP65
D	ASP67
D	SER69
D	THR71
D	GLU76

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 105

Chain	Residue
E	ASP65
E	ASP67
E	SER69
E	THR71
E	GLU76
E	HOH215

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA F 106

Chain	Residue
F	ASP65
F	ASP67
F	SER69
F	THR71
F	GLU76

---

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE TFP A 202

Chain	Residue
A	MET45
A	GLN50
A	GLU56
A	MET60
A	MET80
A	TFP204
B	GLU19
B	PHE20

---

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE TFP A 204

Chain	Residue
A	PHE27
A	LEU48
A	PHE77
A	MET81
A	SER84
A	TFP202
B	MET85
B	TFP203

---

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE TFP B 203

Chain	Residue
A	TFP204
B	PHE27
B	LEU48
B	PHE77
B	MET81
B	VAL82
B	SER84
B	TFP201

---

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE TFP B 201

Chain	Residue
A	GLU15
A	GLU19
A	PHE20
B	GLN50
B	GLU56
B	MET80
B	MET81
B	TFP203

---

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE TFP C 206

Chain	Residue
C	MET45
C	GLN50
C	GLU56
C	MET60
C	MET80
C	TFP208
D	GLU15
D	GLU19
D	PHE20

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE TFP C 208

Chain	Residue
C	PHE27
C	MET81
C	SER84
C	TFP206
D	TFP207

---

site_id	BC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE TFP D 207

Chain	Residue
C	SER84
C	TFP208
D	PHE20
D	PHE27
D	LEU48
D	PHE77
D	MET81
D	SER84
D	TFP205

---

site_id	BC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE TFP D 205

Chain	Residue
D	TFP207
C	GLU19
C	PHE20
C	ALA23
D	MET45
D	GLN50
D	GLU56
D	MET60
D	MET80
D	MET81
D	SER84

---

site_id	BC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE TFP E 210

Chain	Residue
E	MET45
E	GLN50
E	GLU56
E	MET60
E	MET80
E	TFP212
E	HOH216
F	GLU19
F	PHE20

---

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE TFP E 212

Chain	Residue
E	PHE27
E	PHE77
E	MET81
E	SER84
E	TFP210
F	TFP211

---

site_id	BC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE TFP F 211

Chain	Residue
E	TFP212
F	PHE20
F	PHE27
F	LEU48
F	PHE77
F	MET81
F	SER84
F	TFP209

---

site_id	BC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE TFP F 209

Chain	Residue
E	GLU19
E	PHE20
F	MET45
F	GLN50
F	GLU56
F	MET60
F	MET80
F	MET81
F	TFP211

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DEDGSGTVDfdEF

Chain	Residue	Details
A	ASP65-PHE77

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	210
Details	Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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