1WPO

HYDROLYTIC ENZYME HUMAN CYTOMEGALOVIRUS PROTEASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
B	0004252	molecular_function	serine-type endopeptidase activity
B	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 561

Chain	Residue
B	LEU32
B	ARG92
B	ARG166
B	ARG167
B	HOH604
B	HOH606

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"HAMAP-Rule","id":"MF_04008","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8805706","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"HAMAP-Rule","id":"MF_04008","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Cleavage; by assemblin; Cryptic site","evidences":[{"source":"PubMed","id":"12163586","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1nkk

Chain	Residue	Details
A	HIS157
A	HIS63
A	ARG165
A	SER132

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site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1nkk

Chain	Residue	Details
B	HIS157
B	HIS63
B	ARG165
B	SER132

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site_id	MCSA1
Number of Residues	4
Details	M-CSA 238

Chain	Residue	Details
A	HIS63	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	CYS161	electrostatic stabiliser, hydrogen bond acceptor, increase acidity, increase basicity
A	THR169	electrostatic stabiliser, hydrogen bond donor
A	LEU170	electrostatic stabiliser, hydrogen bond donor

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site_id	MCSA2
Number of Residues	4
Details	M-CSA 238

Chain	Residue	Details
B	HIS63	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
B	CYS161	electrostatic stabiliser, hydrogen bond acceptor, increase acidity, increase basicity
B	THR169	electrostatic stabiliser, hydrogen bond donor
B	LEU170	electrostatic stabiliser, hydrogen bond donor

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