Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1WNT

Structure of the tetrameric form of Human L-Xylulose Reductase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001669	cellular_component	acrosomal vesicle
A	0004090	molecular_function	carbonyl reductase (NADPH) activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0005881	cellular_component	cytoplasmic microtubule
A	0005886	cellular_component	plasma membrane
A	0005902	cellular_component	microvillus
A	0005903	cellular_component	brush border
A	0005997	biological_process	xylulose metabolic process
A	0006006	biological_process	glucose metabolic process
A	0016324	cellular_component	apical plasma membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
A	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
A	0019640	biological_process	D-glucuronate catabolic process to D-xylulose 5-phosphate
A	0031410	cellular_component	cytoplasmic vesicle
A	0042732	biological_process	D-xylose metabolic process
A	0042802	molecular_function	identical protein binding
A	0050038	molecular_function	L-xylulose reductase (NADPH) activity
A	0070062	cellular_component	extracellular exosome
A	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
B	0001669	cellular_component	acrosomal vesicle
B	0004090	molecular_function	carbonyl reductase (NADPH) activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0005881	cellular_component	cytoplasmic microtubule
B	0005886	cellular_component	plasma membrane
B	0005902	cellular_component	microvillus
B	0005903	cellular_component	brush border
B	0005997	biological_process	xylulose metabolic process
B	0006006	biological_process	glucose metabolic process
B	0016324	cellular_component	apical plasma membrane
B	0016491	molecular_function	oxidoreductase activity
B	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
B	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
B	0019640	biological_process	D-glucuronate catabolic process to D-xylulose 5-phosphate
B	0031410	cellular_component	cytoplasmic vesicle
B	0042732	biological_process	D-xylose metabolic process
B	0042802	molecular_function	identical protein binding
B	0050038	molecular_function	L-xylulose reductase (NADPH) activity
B	0070062	cellular_component	extracellular exosome
B	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
C	0001669	cellular_component	acrosomal vesicle
C	0004090	molecular_function	carbonyl reductase (NADPH) activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0005881	cellular_component	cytoplasmic microtubule
C	0005886	cellular_component	plasma membrane
C	0005902	cellular_component	microvillus
C	0005903	cellular_component	brush border
C	0005997	biological_process	xylulose metabolic process
C	0006006	biological_process	glucose metabolic process
C	0016324	cellular_component	apical plasma membrane
C	0016491	molecular_function	oxidoreductase activity
C	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
C	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
C	0019640	biological_process	D-glucuronate catabolic process to D-xylulose 5-phosphate
C	0031410	cellular_component	cytoplasmic vesicle
C	0042732	biological_process	D-xylose metabolic process
C	0042802	molecular_function	identical protein binding
C	0050038	molecular_function	L-xylulose reductase (NADPH) activity
C	0070062	cellular_component	extracellular exosome
C	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
D	0001669	cellular_component	acrosomal vesicle
D	0004090	molecular_function	carbonyl reductase (NADPH) activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0005881	cellular_component	cytoplasmic microtubule
D	0005886	cellular_component	plasma membrane
D	0005902	cellular_component	microvillus
D	0005903	cellular_component	brush border
D	0005997	biological_process	xylulose metabolic process
D	0006006	biological_process	glucose metabolic process
D	0016324	cellular_component	apical plasma membrane
D	0016491	molecular_function	oxidoreductase activity
D	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
D	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
D	0019640	biological_process	D-glucuronate catabolic process to D-xylulose 5-phosphate
D	0031410	cellular_component	cytoplasmic vesicle
D	0042732	biological_process	D-xylose metabolic process
D	0042802	molecular_function	identical protein binding
D	0050038	molecular_function	L-xylulose reductase (NADPH) activity
D	0070062	cellular_component	extracellular exosome
D	2000379	biological_process	positive regulation of reactive oxygen species metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	29
Details	BINDING SITE FOR RESIDUE NAP A 245

Chain	Residue
A	GLY14
A	ASP60
A	LEU61
A	GLY62
A	ASN83
A	ALA85
A	ARG102
A	VAL106
A	VAL134
A	SER135
A	TYR149
A	GLY16
A	LYS153
A	PRO179
A	THR180
A	VAL181
A	VAL182
A	THR184
A	SER185
A	MET186
A	GLY187
A	HOH249
A	LYS17
A	GLY18
A	ILE19
A	SER38
A	ARG39
A	THR40
A	VAL59

site_id	AC2
Number of Residues	24
Details	BINDING SITE FOR RESIDUE NAP B 1245

Chain	Residue
B	GLY14
B	GLY16
B	LYS17
B	GLY18
B	ILE19
B	SER38
B	ARG39
B	THR40
B	VAL59
B	ASP60
B	LEU61
B	GLY62
B	ASN83
B	ALA85
B	VAL106
B	VAL134
B	TYR149
B	LYS153
B	THR180
B	VAL182
B	THR184
B	SER185
B	MET186
B	GLY187

site_id	AC3
Number of Residues	25
Details	BINDING SITE FOR RESIDUE NAP C 2245

Chain	Residue
C	GLY14
C	GLY16
C	LYS17
C	GLY18
C	ILE19
C	SER38
C	ARG39
C	THR40
C	ASP43
C	VAL59
C	LEU61
C	ASN83
C	ALA85
C	VAL106
C	VAL134
C	TYR149
C	LYS153
C	PRO179
C	THR180
C	VAL181
C	VAL182
C	THR184
C	MET186
C	GLY187
C	HOH2250

site_id	AC4
Number of Residues	29
Details	BINDING SITE FOR RESIDUE NAP D 3245

Chain	Residue
D	THR180
D	VAL181
D	VAL182
D	THR184
D	SER185
D	MET186
D	GLY187
D	HOH3275
D	GLY14
D	GLY16
D	LYS17
D	GLY18
D	ILE19
D	SER38
D	ARG39
D	THR40
D	ASP43
D	VAL59
D	LEU61
D	ASN83
D	ALA84
D	ALA85
D	ARG102
D	VAL106
D	VAL134
D	SER135
D	TYR149
D	LYS153
D	PRO179

Functional Information from PROSITE/UniProt

site_id	PS00061
Number of Residues	29
Details	ADH_SHORT Short-chain dehydrogenases/reductases family signature. SqcsqravtnHsvYCSTKGALdMLTkVMA

Chain	Residue	Details
A	SER136-ALA164

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	124
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15103634","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"12665801","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
A	SER136
A	TYR149
A	LYS153

site_id	CSA10
Number of Residues	2
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
B	HIS146
B	LYS153

site_id	CSA11
Number of Residues	2
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
C	HIS146
C	LYS153

site_id	CSA12
Number of Residues	2
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
D	HIS146
D	LYS153

site_id	CSA13
Number of Residues	2
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
A	TYR149
A	LYS153

site_id	CSA14
Number of Residues	2
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
B	TYR149
B	LYS153

site_id	CSA15
Number of Residues	2
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
C	TYR149
C	LYS153

site_id	CSA16
Number of Residues	2
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
D	TYR149
D	LYS153

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
B	SER136
B	TYR149
B	LYS153

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
C	SER136
C	TYR149
C	LYS153

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
D	SER136
D	TYR149
D	LYS153

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
A	SER136
A	ASN107
A	TYR149
A	LYS153

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
B	SER136
B	ASN107
B	TYR149
B	LYS153

site_id	CSA7
Number of Residues	4
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
C	SER136
C	ASN107
C	TYR149
C	LYS153

site_id	CSA8
Number of Residues	4
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
D	SER136
D	ASN107
D	TYR149
D	LYS153

site_id	CSA9
Number of Residues	2
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
A	HIS146
A	LYS153

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)