1WNB
Escherichia coli YdcW gene product is a medium-chain aldehyde dehydrogenase (complexed with nadh and betaine aldehyde)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| A | 0004030 | molecular_function | aldehyde dehydrogenase [NAD(P)+] activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0009447 | biological_process | putrescine catabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| A | 0019145 | molecular_function | aminobutyraldehyde dehydrogenase (NAD+) activity |
| A | 0019477 | biological_process | L-lysine catabolic process |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0051287 | molecular_function | NAD binding |
| A | 0051289 | biological_process | protein homotetramerization |
| B | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| B | 0004030 | molecular_function | aldehyde dehydrogenase [NAD(P)+] activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0009447 | biological_process | putrescine catabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0019145 | molecular_function | aminobutyraldehyde dehydrogenase (NAD+) activity |
| B | 0019477 | biological_process | L-lysine catabolic process |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0051287 | molecular_function | NAD binding |
| B | 0051289 | biological_process | protein homotetramerization |
| C | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| C | 0004030 | molecular_function | aldehyde dehydrogenase [NAD(P)+] activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0009447 | biological_process | putrescine catabolic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| C | 0019145 | molecular_function | aminobutyraldehyde dehydrogenase (NAD+) activity |
| C | 0019477 | biological_process | L-lysine catabolic process |
| C | 0032991 | cellular_component | protein-containing complex |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0051287 | molecular_function | NAD binding |
| C | 0051289 | biological_process | protein homotetramerization |
| D | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| D | 0004030 | molecular_function | aldehyde dehydrogenase [NAD(P)+] activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0009447 | biological_process | putrescine catabolic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| D | 0019145 | molecular_function | aminobutyraldehyde dehydrogenase (NAD+) activity |
| D | 0019477 | biological_process | L-lysine catabolic process |
| D | 0032991 | cellular_component | protein-containing complex |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0051287 | molecular_function | NAD binding |
| D | 0051289 | biological_process | protein homotetramerization |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE BTL B 5001 |
| Chain | Residue |
| B | ASP279 |
| B | THR281 |
| B | PHE436 |
| B | LEU438 |
| B | HOH5217 |
| site_id | AC2 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE NAI A 1001 |
| Chain | Residue |
| A | PRO173 |
| A | SER174 |
| A | GLU175 |
| A | GLY204 |
| A | GLY208 |
| A | ASP209 |
| A | LEU222 |
| A | THR223 |
| A | GLY224 |
| A | SER225 |
| A | THR228 |
| A | HIS231 |
| A | GLU246 |
| A | LEU247 |
| A | GLY248 |
| A | CYS280 |
| A | HIS327 |
| A | ARG330 |
| A | PHE380 |
| A | HOH1113 |
| A | HOH1184 |
| A | ILE145 |
| A | ALA146 |
| A | TRP148 |
| A | LYS172 |
| site_id | AC3 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE NAI B 2001 |
| Chain | Residue |
| B | ILE145 |
| B | ALA146 |
| B | PRO147 |
| B | TRP148 |
| B | ASN149 |
| B | LYS172 |
| B | SER174 |
| B | GLU175 |
| B | GLY204 |
| B | GLY208 |
| B | ASP209 |
| B | LEU222 |
| B | THR223 |
| B | GLY224 |
| B | SER225 |
| B | THR228 |
| B | HIS231 |
| B | ILE232 |
| B | GLU246 |
| B | GLY248 |
| B | CYS280 |
| B | HIS327 |
| B | GLU378 |
| B | HOH5065 |
| B | HOH5209 |
| site_id | AC4 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE NAI C 3001 |
| Chain | Residue |
| C | ILE145 |
| C | ALA146 |
| C | PRO147 |
| C | TRP148 |
| C | ASN149 |
| C | LYS172 |
| C | SER174 |
| C | GLU175 |
| C | GLY204 |
| C | GLY208 |
| C | ASP209 |
| C | THR223 |
| C | GLY224 |
| C | SER225 |
| C | THR228 |
| C | HIS231 |
| C | GLY248 |
| C | CYS280 |
| C | ARG330 |
| C | GLU378 |
| C | PHE380 |
| C | HOH3043 |
| C | HOH3183 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE NAI D 4001 |
| Chain | Residue |
| D | ILE145 |
| D | ALA146 |
| D | TRP148 |
| D | LYS172 |
| D | SER174 |
| D | GLU175 |
| D | ARG203 |
| D | GLY204 |
| D | GLY208 |
| D | ASP209 |
| D | SER225 |
| D | THR228 |
| D | HIS231 |
| D | HOH4005 |
| D | HOH4097 |
| D | HOH4170 |
Functional Information from PROSITE/UniProt
| site_id | PS00687 |
| Number of Residues | 8 |
| Details | ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. MELGGKAP |
| Chain | Residue | Details |
| A | MET245-PRO252 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10007 |
| Chain | Residue | Details |
| A | GLU246 | |
| B | GLU246 | |
| C | GLU246 | |
| D | GLU246 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: Nucleophile => ECO:0000305 |
| Chain | Residue | Details |
| A | CYS280 | |
| B | CYS280 | |
| C | CYS280 | |
| D | CYS280 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15381418, ECO:0007744|PDB:1WNB |
| Chain | Residue | Details |
| A | ALA146 | |
| B | CYS280 | |
| C | ALA146 | |
| C | LYS172 | |
| C | ASP209 | |
| C | SER225 | |
| C | CYS280 | |
| D | ALA146 | |
| D | LYS172 | |
| D | ASP209 | |
| D | SER225 | |
| A | LYS172 | |
| D | CYS280 | |
| A | ASP209 | |
| A | SER225 | |
| A | CYS280 | |
| B | ALA146 | |
| B | LYS172 | |
| B | ASP209 | |
| B | SER225 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| A | CYS280 | |
| A | ASN149 | |
| A | GLU246 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| B | CYS280 | |
| B | ASN149 | |
| B | GLU246 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| C | CYS280 | |
| C | ASN149 | |
| C | GLU246 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| D | CYS280 | |
| D | ASN149 | |
| D | GLU246 |
