1WNB

Escherichia coli YdcW gene product is a medium-chain aldehyde dehydrogenase (complexed with nadh and betaine aldehyde)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
A	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
A	0005829	cellular_component	cytosol
A	0009447	biological_process	putrescine catabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0019145	molecular_function	aminobutyraldehyde dehydrogenase (NAD+) activity
A	0019477	biological_process	L-lysine catabolic process
A	0032991	cellular_component	protein-containing complex
A	0042802	molecular_function	identical protein binding
A	0051287	molecular_function	NAD binding
A	0051289	biological_process	protein homotetramerization
B	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
B	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
B	0005829	cellular_component	cytosol
B	0009447	biological_process	putrescine catabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0019145	molecular_function	aminobutyraldehyde dehydrogenase (NAD+) activity
B	0019477	biological_process	L-lysine catabolic process
B	0032991	cellular_component	protein-containing complex
B	0042802	molecular_function	identical protein binding
B	0051287	molecular_function	NAD binding
B	0051289	biological_process	protein homotetramerization
C	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
C	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
C	0005829	cellular_component	cytosol
C	0009447	biological_process	putrescine catabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0019145	molecular_function	aminobutyraldehyde dehydrogenase (NAD+) activity
C	0019477	biological_process	L-lysine catabolic process
C	0032991	cellular_component	protein-containing complex
C	0042802	molecular_function	identical protein binding
C	0051287	molecular_function	NAD binding
C	0051289	biological_process	protein homotetramerization
D	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
D	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
D	0005829	cellular_component	cytosol
D	0009447	biological_process	putrescine catabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0019145	molecular_function	aminobutyraldehyde dehydrogenase (NAD+) activity
D	0019477	biological_process	L-lysine catabolic process
D	0032991	cellular_component	protein-containing complex
D	0042802	molecular_function	identical protein binding
D	0051287	molecular_function	NAD binding
D	0051289	biological_process	protein homotetramerization

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE BTL B 5001

Chain	Residue
B	ASP279
B	THR281
B	PHE436
B	LEU438
B	HOH5217

---

site_id	AC2
Number of Residues	25
Details	BINDING SITE FOR RESIDUE NAI A 1001

Chain	Residue
A	PRO173
A	SER174
A	GLU175
A	GLY204
A	GLY208
A	ASP209
A	LEU222
A	THR223
A	GLY224
A	SER225
A	THR228
A	HIS231
A	GLU246
A	LEU247
A	GLY248
A	CYS280
A	HIS327
A	ARG330
A	PHE380
A	HOH1113
A	HOH1184
A	ILE145
A	ALA146
A	TRP148
A	LYS172

---

site_id	AC3
Number of Residues	25
Details	BINDING SITE FOR RESIDUE NAI B 2001

Chain	Residue
B	ILE145
B	ALA146
B	PRO147
B	TRP148
B	ASN149
B	LYS172
B	SER174
B	GLU175
B	GLY204
B	GLY208
B	ASP209
B	LEU222
B	THR223
B	GLY224
B	SER225
B	THR228
B	HIS231
B	ILE232
B	GLU246
B	GLY248
B	CYS280
B	HIS327
B	GLU378
B	HOH5065
B	HOH5209

---

site_id	AC4
Number of Residues	23
Details	BINDING SITE FOR RESIDUE NAI C 3001

Chain	Residue
C	ILE145
C	ALA146
C	PRO147
C	TRP148
C	ASN149
C	LYS172
C	SER174
C	GLU175
C	GLY204
C	GLY208
C	ASP209
C	THR223
C	GLY224
C	SER225
C	THR228
C	HIS231
C	GLY248
C	CYS280
C	ARG330
C	GLU378
C	PHE380
C	HOH3043
C	HOH3183

---

site_id	AC5
Number of Residues	16
Details	BINDING SITE FOR RESIDUE NAI D 4001

Chain	Residue
D	ILE145
D	ALA146
D	TRP148
D	LYS172
D	SER174
D	GLU175
D	ARG203
D	GLY204
D	GLY208
D	ASP209
D	SER225
D	THR228
D	HIS231
D	HOH4005
D	HOH4097
D	HOH4170

---

Functional Information from PROSITE/UniProt

site_id	PS00687
Number of Residues	8
Details	ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. MELGGKAP

Chain	Residue	Details
A	MET245-PRO252

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10007","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15381418","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1WNB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
A	CYS280
A	ASN149
A	GLU246

---

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
B	CYS280
B	ASN149
B	GLU246

---

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
C	CYS280
C	ASN149
C	GLU246

---

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
D	CYS280
D	ASN149
D	GLU246

---