1WN5
Crystal Structure of Blasticidin S Deaminase (BSD) Complexed with Cacodylic Acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004126 | molecular_function | cytidine deaminase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0047711 | molecular_function | blasticidin-S deaminase activity |
| A | 0055086 | biological_process | nucleobase-containing small molecule metabolic process |
| A | 0072527 | biological_process | pyrimidine-containing compound metabolic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004126 | molecular_function | cytidine deaminase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046677 | biological_process | response to antibiotic |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0047711 | molecular_function | blasticidin-S deaminase activity |
| B | 0055086 | biological_process | nucleobase-containing small molecule metabolic process |
| B | 0072527 | biological_process | pyrimidine-containing compound metabolic process |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004126 | molecular_function | cytidine deaminase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0046677 | biological_process | response to antibiotic |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0047711 | molecular_function | blasticidin-S deaminase activity |
| C | 0055086 | biological_process | nucleobase-containing small molecule metabolic process |
| C | 0072527 | biological_process | pyrimidine-containing compound metabolic process |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004126 | molecular_function | cytidine deaminase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0046677 | biological_process | response to antibiotic |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0047711 | molecular_function | blasticidin-S deaminase activity |
| D | 0055086 | biological_process | nucleobase-containing small molecule metabolic process |
| D | 0072527 | biological_process | pyrimidine-containing compound metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1001 |
| Chain | Residue |
| A | CYS54 |
| A | CYS88 |
| A | CYS91 |
| A | CAC2001 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 1002 |
| Chain | Residue |
| B | CYS54 |
| B | CYS88 |
| B | CYS91 |
| B | CAC2002 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE CAC A 2001 |
| Chain | Residue |
| A | CYS54 |
| A | GLU56 |
| A | LEU85 |
| A | SER86 |
| A | PRO87 |
| A | CYS88 |
| A | CYS91 |
| A | ZN1001 |
| A | HOH2043 |
| B | TYR126 |
| A | VAL29 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 1003 |
| Chain | Residue |
| C | CYS54 |
| C | CYS88 |
| C | CYS91 |
| C | CAC2003 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 1004 |
| Chain | Residue |
| D | CYS54 |
| D | CYS88 |
| D | CYS91 |
| D | CAC2004 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE CAC B 2002 |
| Chain | Residue |
| A | TYR126 |
| B | GLU56 |
| B | LEU85 |
| B | SER86 |
| B | PRO87 |
| B | CYS88 |
| B | CYS91 |
| B | ZN1002 |
| B | HOH2018 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE CAC C 2003 |
| Chain | Residue |
| C | GLU56 |
| C | LEU85 |
| C | SER86 |
| C | PRO87 |
| C | CYS88 |
| C | CYS91 |
| C | ZN1003 |
| C | HOH2016 |
| D | TYR126 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE CAC D 2004 |
| Chain | Residue |
| C | TYR126 |
| D | CYS54 |
| D | GLU56 |
| D | SER86 |
| D | PRO87 |
| D | CYS88 |
| D | CYS91 |
| D | ZN1004 |
| D | HOH2038 |
Functional Information from PROSITE/UniProt
| site_id | PS00903 |
| Number of Residues | 42 |
| Details | CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. CAElvVLgtaaaaaagnltcivaignenrgils.......PCgr......CrqvL |
| Chain | Residue | Details |
| A | CYS54-LEU95 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"description":"in other chain"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Binding site: {} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ctt |
| Chain | Residue | Details |
| A | GLU56 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ctt |
| Chain | Residue | Details |
| B | GLU56 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ctt |
| Chain | Residue | Details |
| C | GLU56 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ctt |
| Chain | Residue | Details |
| D | GLU56 |
