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1WLJ

human ISG20

Functional Information from GO Data
ChainGOidnamespacecontents
A0000175molecular_function3'-5'-RNA exonuclease activity
A0000932cellular_componentP-body
A0003676molecular_functionnucleic acid binding
A0003723molecular_functionRNA binding
A0004527molecular_functionexonuclease activity
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0006308biological_processDNA catabolic process
A0006364biological_processrRNA processing
A0006396biological_processRNA processing
A0006401biological_processRNA catabolic process
A0008310molecular_functionsingle-stranded DNA 3'-5' DNA exonuclease activity
A0008859molecular_functionexoribonuclease II activity
A0009615biological_processresponse to virus
A0015030cellular_componentCajal body
A0016605cellular_componentPML body
A0030619molecular_functionU1 snRNA binding
A0030620molecular_functionU2 snRNA binding
A0034511molecular_functionU3 snoRNA binding
A0045071biological_processnegative regulation of viral genome replication
A0045087biological_processinnate immune response
A0046872molecular_functionmetal ion binding
A0051607biological_processdefense response to virus
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MN A 200
ChainResidue
AASP11
AGLU13
AASP154
AU5P300

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN A 201
ChainResidue
AHOH350
AASP11
AU5P300
AHOH347
AHOH348
AHOH349

site_idAC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE MN A 202
ChainResidue
AASP90
AHIS93

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ACT A 203
ChainResidue
ATHR50
ATYR108
AASP109
ATHR112
AHOH353

site_idAC5
Number of Residues14
DetailsBINDING SITE FOR RESIDUE U5P A 300
ChainResidue
AASP11
ACYS12
AGLU13
AMET14
AARG53
ASER57
AGLN143
AHIS149
AASP154
AMN200
AMN201
AHOH321
AHOH341
AHOH350

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues5
DetailsBINDING:
ChainResidueDetails
AASP11
AGLU13
AASP90
AHIS93
AASP154

227344

PDB entries from 2024-11-13

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