1WA8
Solution Structure of the CFP-10.ESAT-6 Complex. Major Virulence Determinants of Pathogenic Mycobacteria
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0009274 | cellular_component | peptidoglycan-based cell wall |
| B | 0020002 | cellular_component | host cell plasma membrane |
| B | 0030430 | cellular_component | host cell cytoplasm |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0044165 | cellular_component | host cell endoplasmic reticulum |
| B | 0044228 | cellular_component | host cell surface |
| B | 0044315 | biological_process | protein secretion by the type VII secretion system |
| B | 0046812 | molecular_function | host cell surface binding |
| B | 0052027 | biological_process | symbiont-mediated perturbation of host signal transduction pathway |
| B | 0052085 | biological_process | symbiont-mediated suppression of host T-cell mediated immune response |
| B | 0052170 | biological_process | symbiont-mediated suppression of host innate immune response |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 19 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 37 |
| Details | Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 68 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"25645924","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | Region: {"description":"Not required for ESAT-6/CFP-10 complex to bind to host macrophage and monocytes","evidences":[{"source":"PubMed","id":"15973432","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 31 |
| Details | Coiled coil: {"evidences":[{"source":"PubMed","id":"16048998","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 31 |
| Details | Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16048998","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylthreonine; partial","evidences":[{"source":"PubMed","id":"15378760","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21969609","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
