1W6S
The high resolution structure of methanol dehydrogenase from methylobacterium extorquens
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0015945 | biological_process | methanol metabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016614 | molecular_function | oxidoreductase activity, acting on CH-OH group of donors |
| A | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052933 | molecular_function | alcohol dehydrogenase (cytochrome c(L)) activity |
| A | 0070968 | molecular_function | pyrroloquinoline quinone binding |
| B | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
| B | 0015945 | biological_process | methanol metabolic process |
| B | 0015946 | biological_process | methanol oxidation |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0042597 | cellular_component | periplasmic space |
| B | 0052933 | molecular_function | alcohol dehydrogenase (cytochrome c(L)) activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0005509 | molecular_function | calcium ion binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0015945 | biological_process | methanol metabolic process |
| C | 0016020 | cellular_component | membrane |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016614 | molecular_function | oxidoreductase activity, acting on CH-OH group of donors |
| C | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0052933 | molecular_function | alcohol dehydrogenase (cytochrome c(L)) activity |
| C | 0070968 | molecular_function | pyrroloquinoline quinone binding |
| D | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
| D | 0015945 | biological_process | methanol metabolic process |
| D | 0015946 | biological_process | methanol oxidation |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0042597 | cellular_component | periplasmic space |
| D | 0052933 | molecular_function | alcohol dehydrogenase (cytochrome c(L)) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A1599 |
| Chain | Residue |
| A | GLU177 |
| A | ASN261 |
| A | ASP303 |
| A | PQQ1596 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA C3599 |
| Chain | Residue |
| C | GLU2177 |
| C | ASN2261 |
| C | ASP2303 |
| C | PQQ3597 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE PQQ A1596 |
| Chain | Residue |
| A | CYS104 |
| A | VAL107 |
| A | ARG109 |
| A | THR159 |
| A | SER174 |
| A | GLY175 |
| A | ALA176 |
| A | GLU177 |
| A | THR241 |
| A | TRP243 |
| A | ASN261 |
| A | ARG331 |
| A | ASN394 |
| A | TRP476 |
| A | GLY539 |
| A | TRP540 |
| A | CA1599 |
| A | HOH2329 |
| A | HOH2602 |
| A | GLU55 |
| site_id | AC4 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE PQQ C3597 |
| Chain | Residue |
| C | GLU2055 |
| C | CYS2104 |
| C | VAL2107 |
| C | ARG2109 |
| C | THR2159 |
| C | SER2174 |
| C | GLY2175 |
| C | ALA2176 |
| C | GLU2177 |
| C | THR2241 |
| C | TRP2243 |
| C | ASN2261 |
| C | ARG2331 |
| C | ASN2394 |
| C | TRP2476 |
| C | GLY2539 |
| C | TRP2540 |
| C | CA3599 |
| C | HOH4356 |
| C | HOH4609 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A1597 |
| Chain | Residue |
| A | ALA43 |
| A | GLY584 |
| A | PRO585 |
| A | TYR586 |
| A | ASP587 |
| A | HOH2603 |
| A | HOH2604 |
| C | ARG2041 |
| C | TRP2508 |
| C | LYS2509 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A1598 |
| Chain | Residue |
| A | HIS525 |
| A | THR528 |
| A | TYR530 |
| A | LYS583 |
| A | PRO585 |
| A | HOH2132 |
| A | HOH2135 |
| A | HOH2605 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL C3598 |
| Chain | Residue |
| A | TRP508 |
| A | LYS509 |
| A | HOH2095 |
| C | ALA2043 |
| C | GLY2582 |
| C | GLY2584 |
| C | PRO2585 |
| C | TYR2586 |
| C | ASP2587 |
| C | HOH4610 |
Functional Information from PROSITE/UniProt
| site_id | PS00363 |
| Number of Residues | 29 |
| Details | BACTERIAL_PQQ_1 Bacterial quinoprotein dehydrogenases signature 1. NWvmpGKnydsnnFSdlkqINkgNVkqLR |
| Chain | Residue | Details |
| A | ASN13-ARG41 |
| site_id | PS00364 |
| Number of Residues | 22 |
| Details | BACTERIAL_PQQ_2 Bacterial quinoprotein dehydrogenases signature 2. WgwyaYDpgtNLIYFgtGnpAP |
| Chain | Residue | Details |
| A | TRP243-PRO264 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 60 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 22 |
| Details | Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1g72 |
| Chain | Residue | Details |
| A | ASP303 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1g72 |
| Chain | Residue | Details |
| C | ASP2303 |
