1W6Q
X-RAY CRYSTAL STRUCTURE OF R111H HUMAN GALECTIN-1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005788 | cellular_component | endoplasmic reticulum lumen |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006915 | biological_process | apoptotic process |
| A | 0007165 | biological_process | signal transduction |
| A | 0030246 | molecular_function | carbohydrate binding |
| A | 0030395 | molecular_function | lactose binding |
| A | 0031012 | cellular_component | extracellular matrix |
| A | 0042981 | biological_process | regulation of apoptotic process |
| A | 0043065 | biological_process | positive regulation of apoptotic process |
| A | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| A | 0043236 | molecular_function | laminin binding |
| A | 0046598 | biological_process | positive regulation of viral entry into host cell |
| A | 0048018 | molecular_function | receptor ligand activity |
| A | 0050729 | biological_process | positive regulation of inflammatory response |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0098609 | biological_process | cell-cell adhesion |
| A | 2000329 | biological_process | negative regulation of T-helper 17 cell lineage commitment |
| A | 2001200 | biological_process | positive regulation of dendritic cell differentiation |
| B | 0003723 | molecular_function | RNA binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005788 | cellular_component | endoplasmic reticulum lumen |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006915 | biological_process | apoptotic process |
| B | 0007165 | biological_process | signal transduction |
| B | 0030246 | molecular_function | carbohydrate binding |
| B | 0030395 | molecular_function | lactose binding |
| B | 0031012 | cellular_component | extracellular matrix |
| B | 0042981 | biological_process | regulation of apoptotic process |
| B | 0043065 | biological_process | positive regulation of apoptotic process |
| B | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| B | 0043236 | molecular_function | laminin binding |
| B | 0046598 | biological_process | positive regulation of viral entry into host cell |
| B | 0048018 | molecular_function | receptor ligand activity |
| B | 0050729 | biological_process | positive regulation of inflammatory response |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0098609 | biological_process | cell-cell adhesion |
| B | 2000329 | biological_process | negative regulation of T-helper 17 cell lineage commitment |
| B | 2001200 | biological_process | positive regulation of dendritic cell differentiation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BME A2135 |
| Chain | Residue |
| A | CYS1060 |
| A | GLN1072 |
| A | GLU1074 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE BME A2136 |
| Chain | Residue |
| A | VAL1087 |
| A | CYS1088 |
| A | LYS1099 |
| A | LEU1100 |
| A | PRO1101 |
| A | HOH2054 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE BME A2137 |
| Chain | Residue |
| A | ARG1018 |
| A | VAL1019 |
| A | ARG1020 |
| A | CYS1130 |
| A | VAL1131 |
| A | ALA1132 |
| B | PRO2025 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BME B3135 |
| Chain | Residue |
| B | CYS2016 |
| B | CYS2088 |
| B | ILE2089 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE BME B3136 |
| Chain | Residue |
| B | GLU2086 |
| B | CYS2088 |
| B | PRO2101 |
| B | HOH4068 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE BME B3137 |
| Chain | Residue |
| B | ARG2018 |
| B | ARG2020 |
| B | ASP2026 |
| B | GLU2086 |
| B | CYS2130 |
| B | ALA2132 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P16045","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by FAM20C","evidences":[{"source":"PubMed","id":"26091039","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P16045","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 131 |
| Details | Domain: {"description":"Galectin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00639","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
