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1W6Q

X-RAY CRYSTAL STRUCTURE OF R111H HUMAN GALECTIN-1

Functional Information from GO Data
ChainGOidnamespacecontents
A0002317biological_processplasma cell differentiation
A0003723molecular_functionRNA binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005788cellular_componentendoplasmic reticulum lumen
A0005829cellular_componentcytosol
A0006915biological_processapoptotic process
A0016936molecular_functiongalactoside binding
A0030246molecular_functioncarbohydrate binding
A0030395molecular_functionlactose binding
A0031295biological_processT cell costimulation
A0042981biological_processregulation of apoptotic process
A0043065biological_processpositive regulation of apoptotic process
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043236molecular_functionlaminin binding
A0045445biological_processmyoblast differentiation
A0046598biological_processpositive regulation of viral entry into host cell
A0050729biological_processpositive regulation of inflammatory response
A0062023cellular_componentcollagen-containing extracellular matrix
A0070062cellular_componentextracellular exosome
A0098609biological_processcell-cell adhesion
A1990724cellular_componentgalectin complex
A2001200biological_processpositive regulation of dendritic cell differentiation
B0002317biological_processplasma cell differentiation
B0003723molecular_functionRNA binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0005788cellular_componentendoplasmic reticulum lumen
B0005829cellular_componentcytosol
B0006915biological_processapoptotic process
B0016936molecular_functiongalactoside binding
B0030246molecular_functioncarbohydrate binding
B0030395molecular_functionlactose binding
B0031295biological_processT cell costimulation
B0042981biological_processregulation of apoptotic process
B0043065biological_processpositive regulation of apoptotic process
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0043236molecular_functionlaminin binding
B0045445biological_processmyoblast differentiation
B0046598biological_processpositive regulation of viral entry into host cell
B0050729biological_processpositive regulation of inflammatory response
B0062023cellular_componentcollagen-containing extracellular matrix
B0070062cellular_componentextracellular exosome
B0098609biological_processcell-cell adhesion
B1990724cellular_componentgalectin complex
B2001200biological_processpositive regulation of dendritic cell differentiation
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE BME A2135
ChainResidue
ACYS1060
AGLN1072
AGLU1074

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE BME A2136
ChainResidue
AVAL1087
ACYS1088
ALYS1099
ALEU1100
APRO1101
AHOH2054

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE BME A2137
ChainResidue
AARG1018
AVAL1019
AARG1020
ACYS1130
AVAL1131
AALA1132
BPRO2025

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE BME B3135
ChainResidue
BCYS2016
BCYS2088
BILE2089

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE BME B3136
ChainResidue
BGLU2086
BCYS2088
BPRO2101
BHOH4068

site_idAC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE BME B3137
ChainResidue
BARG2018
BARG2020
BASP2026
BGLU2086
BCYS2130
BALA2132

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING:
ChainResidueDetails
BPHE2045
BGLY2053
BSER2062
BGLY2069

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712
ChainResidueDetails
BCYS2002

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P16045
ChainResidueDetails
BPRO2013
BILE2128

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
BSER2029

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039
ChainResidueDetails
BPHE2030

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P16045
ChainResidueDetails
BPHE2108

218853

PDB entries from 2024-04-24

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