1W57

Structure of the Bifunctional IspDF from Campylobacter jejuni containing Zn

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0008299	biological_process	isoprenoid biosynthetic process
A	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A	0016114	biological_process	terpenoid biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0016829	molecular_function	lyase activity
A	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
A	0046872	molecular_function	metal ion binding
A	0050518	molecular_function	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A	0070567	molecular_function	cytidylyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A1371

Chain	Residue
A	ASP217
A	HIS219
A	HIS243
A	HIS251
A	HOH2057

---

site_id	AC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE C5P A1372

Chain	Residue
A	GLU268
A	ALA309
A	PRO312
A	LYS313
A	LEU314
A	LYS315
A	LYS318
A	ALA340
A	THR341
A	THR342
A	GLU344
A	HOH2041
A	HOH2055
A	HOH2057
A	ASP217
A	ASP265
A	ILE266
A	GLY267

---

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE C5P A1373

Chain	Residue
A	LEU9
A	ALA10
A	ALA11
A	THR53
A	GLY73
A	ASP74
A	THR75
A	ARG76
A	SER79
A	ASP96
A	VAL97
A	ALA98
A	ARG139
A	LYS191

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GPP A1374

Chain	Residue
A	PHE216
A	MET308
A	GLY347
A	PHE348
A	ARG351

---

Functional Information from PROSITE/UniProt

site_id	PS01295
Number of Residues	8
Details	ISPD 4-diphosphocytidyl-2C-methyl-D-erythritol synthase signature. VMVSDVAR

Chain	Residue	Details
A	VAL92-ARG99

---

site_id	PS01350
Number of Residues	16
Details	ISPF 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase signature. SDGDVLaHSltDAilG

Chain	Residue	Details
A	SER244-GLY259

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	17
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P62617","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_01520","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P62617","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"HAMAP-Rule","id":"MF_01520","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Site: {"description":"Positions MEP for the nucleophilic attack","evidences":[{"source":"HAMAP-Rule","id":"MF_01520","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"UniProtKB","id":"P62617","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_01520","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1hv9

Chain	Residue	Details
A	ARG16

---