1W45

The 2.5 Angstroem structure of the K16A mutant of annexin A8, which has an intact N-terminus.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001786	molecular_function	phosphatidylserine binding
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005544	molecular_function	calcium-dependent phospholipid binding
A	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
A	0005547	molecular_function	phosphatidylinositol-3,4,5-trisphosphate binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0007032	biological_process	endosome organization
A	0007596	biological_process	blood coagulation
A	0007599	biological_process	hemostasis
A	0012506	cellular_component	vesicle membrane
A	0016197	biological_process	endosomal transport
A	0019834	molecular_function	phospholipase A2 inhibitor activity
A	0031012	cellular_component	extracellular matrix
A	0031902	cellular_component	late endosome membrane
A	0042383	cellular_component	sarcolemma
A	0043325	molecular_function	phosphatidylinositol-3,4-bisphosphate binding
A	0046872	molecular_function	metal ion binding
A	0051015	molecular_function	actin filament binding
B	0001786	molecular_function	phosphatidylserine binding
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005544	molecular_function	calcium-dependent phospholipid binding
B	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
B	0005547	molecular_function	phosphatidylinositol-3,4,5-trisphosphate binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0007032	biological_process	endosome organization
B	0007596	biological_process	blood coagulation
B	0007599	biological_process	hemostasis
B	0012506	cellular_component	vesicle membrane
B	0016197	biological_process	endosomal transport
B	0019834	molecular_function	phospholipase A2 inhibitor activity
B	0031012	cellular_component	extracellular matrix
B	0031902	cellular_component	late endosome membrane
B	0042383	cellular_component	sarcolemma
B	0043325	molecular_function	phosphatidylinositol-3,4-bisphosphate binding
B	0046872	molecular_function	metal ion binding
B	0051015	molecular_function	actin filament binding

Functional Information from PROSITE/UniProt

site_id	PS00223
Number of Residues	53
Details	ANNEXIN_1 Annexin repeat signature. GTneqaiidvLtkRsntQrqQiaksFkaqfgkdLtetLkselsGkferlIvaL

Chain	Residue	Details
A	GLY38-LEU90
A	GLY110-LEU162
A	GLY195-VAL247
A	GLY270-LEU322

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	142
Details	Repeat: {"description":"Annexin 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	142
Details	Repeat: {"description":"Annexin 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	144
Details	Repeat: {"description":"Annexin 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	142
Details	Repeat: {"description":"Annexin 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {}

Chain

Residue

Details

---