1VZ7
Ornithine Acetyltransferase (ORF6 Gene Product - Clavulanic Acid Biosynthesis) from Streptomyces clavuligerus
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004042 | molecular_function | acetyl-CoA:L-glutamate N-acetyltransferase activity |
| A | 0004358 | molecular_function | glutamate N-acetyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006526 | biological_process | arginine biosynthetic process |
| A | 0006592 | biological_process | ornithine biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0033050 | biological_process | clavulanic acid biosynthetic process |
| B | 0004042 | molecular_function | acetyl-CoA:L-glutamate N-acetyltransferase activity |
| B | 0004358 | molecular_function | glutamate N-acetyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006526 | biological_process | arginine biosynthetic process |
| B | 0006592 | biological_process | ornithine biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0033050 | biological_process | clavulanic acid biosynthetic process |
| C | 0004042 | molecular_function | acetyl-CoA:L-glutamate N-acetyltransferase activity |
| C | 0004358 | molecular_function | glutamate N-acetyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006526 | biological_process | arginine biosynthetic process |
| C | 0006592 | biological_process | ornithine biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016746 | molecular_function | acyltransferase activity |
| C | 0033050 | biological_process | clavulanic acid biosynthetic process |
| D | 0004042 | molecular_function | acetyl-CoA:L-glutamate N-acetyltransferase activity |
| D | 0004358 | molecular_function | glutamate N-acetyltransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006526 | biological_process | arginine biosynthetic process |
| D | 0006592 | biological_process | ornithine biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016746 | molecular_function | acyltransferase activity |
| D | 0033050 | biological_process | clavulanic acid biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A1391 |
| Chain | Residue |
| A | THR111 |
| A | GLY112 |
| A | THR148 |
| A | LYS170 |
| A | THR181 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B1391 |
| Chain | Residue |
| B | LYS170 |
| B | MET174 |
| B | THR181 |
| B | THR111 |
| B | GLY112 |
| B | THR148 |
| B | THR149 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C1391 |
| Chain | Residue |
| C | THR111 |
| C | GLY112 |
| C | THR148 |
| C | THR149 |
| C | LYS170 |
| C | THR181 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D1391 |
| Chain | Residue |
| D | THR111 |
| D | GLY112 |
| D | THR148 |
| D | THR149 |
| D | LYS170 |
| D | THR181 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Nucleophile |
| Chain | Residue | Details |
| A | THR181 | |
| B | THR181 | |
| C | THR181 | |
| D | THR181 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | THR148 | |
| A | LYS170 | |
| B | THR148 | |
| B | LYS170 | |
| C | THR148 | |
| C | LYS170 | |
| D | THR148 | |
| D | LYS170 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21796301 |
| Chain | Residue | Details |
| A | THR181 | |
| C | GLU260 | |
| C | ASN388 | |
| C | THR393 | |
| D | THR181 | |
| D | GLU260 | |
| D | ASN388 | |
| D | THR393 | |
| A | GLU260 | |
| A | ASN388 | |
| A | THR393 | |
| B | THR181 | |
| B | GLU260 | |
| B | ASN388 | |
| B | THR393 | |
| C | THR181 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | SITE: Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole => ECO:0000250 |
| Chain | Residue | Details |
| A | THR111 | |
| B | THR111 | |
| C | THR111 | |
| D | THR111 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | SITE: Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole |
| Chain | Residue | Details |
| A | GLY112 | |
| B | GLY112 | |
| C | GLY112 | |
| D | GLY112 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | SITE: Cleavage; by autolysis |
| Chain | Residue | Details |
| A | ALA180 | |
| B | ALA180 | |
| C | ALA180 | |
| D | ALA180 |
