1VYQ
Novel inhibitors of Plasmodium Falciparum dUTPase provide a platform for anti-malarial drug design
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004170 | molecular_function | dUTP diphosphatase activity |
| A | 0006226 | biological_process | dUMP biosynthetic process |
| A | 0006260 | biological_process | DNA replication |
| A | 0006399 | biological_process | tRNA metabolic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046081 | biological_process | dUTP catabolic process |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004170 | molecular_function | dUTP diphosphatase activity |
| B | 0006226 | biological_process | dUMP biosynthetic process |
| B | 0006260 | biological_process | DNA replication |
| B | 0006399 | biological_process | tRNA metabolic process |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046081 | biological_process | dUTP catabolic process |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0004170 | molecular_function | dUTP diphosphatase activity |
| C | 0006226 | biological_process | dUMP biosynthetic process |
| C | 0006260 | biological_process | DNA replication |
| C | 0006399 | biological_process | tRNA metabolic process |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0046081 | biological_process | dUTP catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE DUX A1160 |
| Chain | Residue |
| A | PHE46 |
| C | LYS48 |
| C | HOH2017 |
| A | LEU88 |
| A | ASN103 |
| A | GLY106 |
| A | TYR112 |
| A | ILE117 |
| A | HOH2051 |
| B | SER92 |
| B | SER93 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE DUX B1160 |
| Chain | Residue |
| B | ASN103 |
| B | GLY106 |
| B | TYR112 |
| B | ILE117 |
| B | ALA119 |
| B | HOH2025 |
| C | SER92 |
| C | SER95 |
| C | LYS96 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE DUX C1160 |
| Chain | Residue |
| A | VAL6 |
| A | LYS52 |
| A | SER92 |
| A | SER95 |
| A | GLU153 |
| C | PHE46 |
| C | ASN103 |
| C | GLY106 |
| C | TYR112 |
| C | ILE116 |
| C | ILE117 |
| C | ALA119 |
| C | HOH2042 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dup |
| Chain | Residue | Details |
| A | ASP109 | |
| A | GLY111 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dup |
| Chain | Residue | Details |
| B | ASP109 | |
| B | GLY111 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dup |
| Chain | Residue | Details |
| C | ASP109 | |
| C | GLY111 |
