1VYQ

Novel inhibitors of Plasmodium Falciparum dUTPase provide a platform for anti-malarial drug design

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004170	molecular_function	dUTP diphosphatase activity
A	0006226	biological_process	dUMP biosynthetic process
A	0006260	biological_process	DNA replication
A	0006399	biological_process	tRNA metabolic process
A	0009117	biological_process	nucleotide metabolic process
A	0016787	molecular_function	hydrolase activity
A	0042802	molecular_function	identical protein binding
A	0046081	biological_process	dUTP catabolic process
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0004170	molecular_function	dUTP diphosphatase activity
B	0006226	biological_process	dUMP biosynthetic process
B	0006260	biological_process	DNA replication
B	0006399	biological_process	tRNA metabolic process
B	0009117	biological_process	nucleotide metabolic process
B	0016787	molecular_function	hydrolase activity
B	0042802	molecular_function	identical protein binding
B	0046081	biological_process	dUTP catabolic process
B	0046872	molecular_function	metal ion binding
C	0000287	molecular_function	magnesium ion binding
C	0004170	molecular_function	dUTP diphosphatase activity
C	0006226	biological_process	dUMP biosynthetic process
C	0006260	biological_process	DNA replication
C	0006399	biological_process	tRNA metabolic process
C	0009117	biological_process	nucleotide metabolic process
C	0016787	molecular_function	hydrolase activity
C	0042802	molecular_function	identical protein binding
C	0046081	biological_process	dUTP catabolic process
C	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE DUX A1160

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE DUX B1160

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE DUX C1160