1VPW
STRUCTURE OF THE PURR MUTANT, L54M, BOUND TO HYPOXANTHINE AND PURF OPERATOR DNA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000976 | molecular_function | transcription cis-regulatory region binding |
| A | 0001217 | molecular_function | DNA-binding transcription repressor activity |
| A | 0002057 | molecular_function | guanine binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 1900372 | biological_process | negative regulation of purine nucleotide biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE HPA A 599 |
| Chain | Residue |
| A | TYR73 |
| A | PHE74 |
| A | ARG190 |
| A | THR192 |
| A | ARG196 |
| A | PHE221 |
| A | ASP275 |
| A | HOH618 |
| A | HOH628 |
Functional Information from PROSITE/UniProt
| site_id | PS00356 |
| Number of Residues | 19 |
| Details | HTH_LACI_1 LacI-type HTH domain signature. IkDVAkrAnVSttTVshVI |
| Chain | Residue | Details |
| A | ILE4-ILE22 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 19 |
| Details | DNA binding: {"description":"H-T-H motif"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | DNA binding: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11781089","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9628480","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-1999","submissionDatabase":"PDB data bank","title":"The roles of exocyclic groups in the central base-pair step in modulating the affinity of PurR for its operator.","authors":["Zheleznova E.E.","Brennan R.G."]}},{"source":"PDB","id":"1JFS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VPW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZAY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Site: {"description":"Is the key determinant of 6-oxopurine corepressor specificity"} |
| Chain | Residue | Details |
