Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004032 | molecular_function | aldose reductase (NADPH) activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004032 | molecular_function | aldose reductase (NADPH) activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NAP A 300 |
| Chain | Residue |
| A | GLY20 |
| A | TRP188 |
| A | GLY189 |
| A | PRO190 |
| A | PHE191 |
| A | ALA192 |
| A | GLU193 |
| A | PHE199 |
| A | ALA216 |
| A | ILE231 |
| A | PRO232 |
| A | VAL21 |
| A | LYS233 |
| A | THR234 |
| A | VAL235 |
| A | ARG239 |
| A | GLU242 |
| A | ASN243 |
| A | HOH359 |
| A | HOH401 |
| A | PHE22 |
| A | ASP45 |
| A | TYR50 |
| A | HIS112 |
| A | SER140 |
| A | ASN141 |
| A | GLN162 |
| site_id | AC2 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NAP B 300 |
| Chain | Residue |
| B | GLY20 |
| B | VAL21 |
| B | PHE22 |
| B | ASP45 |
| B | TYR50 |
| B | SER140 |
| B | ASN141 |
| B | GLN162 |
| B | TRP188 |
| B | GLY189 |
| B | PRO190 |
| B | PHE191 |
| B | ALA192 |
| B | GLU193 |
| B | PHE199 |
| B | ALA216 |
| B | ILE231 |
| B | PRO232 |
| B | LYS233 |
| B | THR234 |
| B | VAL235 |
| B | ARG236 |
| B | ARG239 |
| B | GLU242 |
| B | ASN243 |
| B | HOH324 |
| B | HOH374 |
Functional Information from PROSITE/UniProt
| site_id | PS00062 |
| Number of Residues | 18 |
| Details | ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. MeemykdglVRAIGVSNF |
| Chain | Residue | Details |
| A | MET125-PHE142 | |
| site_id | PS00798 |
| Number of Residues | 18 |
| Details | ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRLIDTAasymnEegVG |
| Chain | Residue | Details |
| A | GLY40-GLY57 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1mrq |
| Chain | Residue | Details |
| A | LYS79 | |
| A | ASP45 | |
| A | HIS112 | |
| A | TYR50 | |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1mrq |
| Chain | Residue | Details |
| B | LYS79 | |
| B | ASP45 | |
| B | HIS112 | |
| B | TYR50 | |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1mrq |
| Chain | Residue | Details |
| A | LYS79 | |
| A | TYR50 | |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1mrq |
| Chain | Residue | Details |
| B | LYS79 | |
| B | TYR50 | |
