1VLR
Crystal structure of mRNA decapping enzyme (DcpS) from Mus musculus at 1.83 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000288 | biological_process | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| A | 0000290 | biological_process | deadenylation-dependent decapping of nuclear-transcribed mRNA |
| A | 0000340 | molecular_function | RNA 7-methylguanosine cap binding |
| A | 0000932 | cellular_component | P-body |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006397 | biological_process | mRNA processing |
| A | 0008380 | biological_process | RNA splicing |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0045292 | biological_process | mRNA cis splicing, via spliceosome |
| A | 0110156 | biological_process | mRNA methylguanosine-cap decapping |
| A | 0140932 | molecular_function | 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity |
| B | 0000288 | biological_process | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| B | 0000290 | biological_process | deadenylation-dependent decapping of nuclear-transcribed mRNA |
| B | 0000340 | molecular_function | RNA 7-methylguanosine cap binding |
| B | 0000932 | cellular_component | P-body |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0006397 | biological_process | mRNA processing |
| B | 0008380 | biological_process | RNA splicing |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0045292 | biological_process | mRNA cis splicing, via spliceosome |
| B | 0110156 | biological_process | mRNA methylguanosine-cap decapping |
| B | 0140932 | molecular_function | 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 339 |
| Chain | Residue |
| B | GLY45 |
| B | ARG47 |
| B | LYS66 |
| B | VAL67 |
| B | GLU69 |
| B | GLU235 |
| B | HOH565 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 339 |
| Chain | Residue |
| A | GLU249 |
| A | ALA250 |
| A | LYS253 |
| A | HOH568 |
| A | PHE190 |
| A | GLU246 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO A 340 |
| Chain | Residue |
| A | GLY76 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 341 |
| Chain | Residue |
| A | GLN299 |
| A | HOH630 |
| B | ASN303 |
| B | HIS310 |
| B | ARG314 |
| B | THR315 |
| B | LEU316 |
| B | HOH701 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 342 |
| Chain | Residue |
| A | ASN303 |
| A | HIS310 |
| A | ARG314 |
| A | THR315 |
| A | LEU316 |
| A | HOH373 |
| A | HOH497 |
| B | GLN299 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 340 |
| Chain | Residue |
| A | HOH444 |
| B | PRO119 |
| B | PRO120 |
| B | ARG121 |
| B | SER124 |
Functional Information from PROSITE/UniProt
| site_id | PS00892 |
| Number of Residues | 19 |
| Details | HIT_1 HIT domain signature. RvylhYlPsYyHLHVHFTA |
| Chain | Residue | Details |
| A | ARG263-ALA281 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Nucleophile => ECO:0000250 |
| Chain | Residue | Details |
| A | HIS276 | |
| B | HIS276 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | TRP174 | |
| A | GLU184 | |
| A | ASP204 | |
| A | LYS206 | |
| B | LYS206 | |
| B | HIS267 | |
| A | HIS267 | |
| B | TRP174 | |
| B | GLU184 | |
| B | ASP204 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:Q96C86 |
| Chain | Residue | Details |
| A | ALA2 | |
| B | ALA2 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q96C86 |
| Chain | Residue | Details |
| A | SER23 | |
| B | SER23 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079 |
| Chain | Residue | Details |
| A | SER100 | |
| B | SER100 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:23806337 |
| Chain | Residue | Details |
| A | LYS137 | |
| B | LYS137 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q96C86 |
| Chain | Residue | Details |
| A | LYS141 | |
| B | LYS141 |
