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1VHR

HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE

Functional Information from GO Data
ChainGOidnamespacecontents
A0001772cellular_componentimmunological synapse
A0004721molecular_functionphosphoprotein phosphatase activity
A0004722molecular_functionprotein serine/threonine phosphatase activity
A0004725molecular_functionprotein tyrosine phosphatase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006470biological_processprotein dephosphorylation
A0008092molecular_functioncytoskeletal protein binding
A0008138molecular_functionprotein tyrosine/serine/threonine phosphatase activity
A0016311biological_processdephosphorylation
A0016787molecular_functionhydrolase activity
A0016791molecular_functionphosphatase activity
A0017018molecular_functionmyosin phosphatase activity
A0019901molecular_functionprotein kinase binding
A0030336biological_processnegative regulation of cell migration
A0030971molecular_functionreceptor tyrosine kinase binding
A0033549molecular_functionMAP kinase phosphatase activity
A0035335biological_processpeptidyl-tyrosine dephosphorylation
A0042059biological_processnegative regulation of epidermal growth factor receptor signaling pathway
A0043409biological_processnegative regulation of MAPK cascade
A0045931biological_processpositive regulation of mitotic cell cycle
A0046329biological_processnegative regulation of JNK cascade
A0050860biological_processnegative regulation of T cell receptor signaling pathway
A0050868biological_processnegative regulation of T cell activation
A0050922biological_processnegative regulation of chemotaxis
A0051893biological_processregulation of focal adhesion assembly
A0070373biological_processnegative regulation of ERK1 and ERK2 cascade
A0071364biological_processcellular response to epidermal growth factor stimulus
A0120183biological_processpositive regulation of focal adhesion disassembly
A1990264biological_processpeptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
A1990782molecular_functionprotein tyrosine kinase binding
B0001772cellular_componentimmunological synapse
B0004721molecular_functionphosphoprotein phosphatase activity
B0004722molecular_functionprotein serine/threonine phosphatase activity
B0004725molecular_functionprotein tyrosine phosphatase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006470biological_processprotein dephosphorylation
B0008092molecular_functioncytoskeletal protein binding
B0008138molecular_functionprotein tyrosine/serine/threonine phosphatase activity
B0016311biological_processdephosphorylation
B0016787molecular_functionhydrolase activity
B0016791molecular_functionphosphatase activity
B0017018molecular_functionmyosin phosphatase activity
B0019901molecular_functionprotein kinase binding
B0030336biological_processnegative regulation of cell migration
B0030971molecular_functionreceptor tyrosine kinase binding
B0033549molecular_functionMAP kinase phosphatase activity
B0035335biological_processpeptidyl-tyrosine dephosphorylation
B0042059biological_processnegative regulation of epidermal growth factor receptor signaling pathway
B0043409biological_processnegative regulation of MAPK cascade
B0045931biological_processpositive regulation of mitotic cell cycle
B0046329biological_processnegative regulation of JNK cascade
B0050860biological_processnegative regulation of T cell receptor signaling pathway
B0050868biological_processnegative regulation of T cell activation
B0050922biological_processnegative regulation of chemotaxis
B0051893biological_processregulation of focal adhesion assembly
B0070373biological_processnegative regulation of ERK1 and ERK2 cascade
B0071364biological_processcellular response to epidermal growth factor stimulus
B0120183biological_processpositive regulation of focal adhesion disassembly
B1990264biological_processpeptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
B1990782molecular_functionprotein tyrosine kinase binding
Functional Information from PDB Data
site_idAC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE SO4 B 502
ChainResidue
BASP92
BCYS124
BARG125
BGLU126
BGLY127
BTYR128
BSER129
BARG130
BHOH657

site_idAC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE EPE A 401
ChainResidue
AASP92
ACYS124
AARG125
AGLU126
AGLY127
ATYR128
ASER129
AARG130

site_idGAA
Number of Residues11
DetailsTHE LOOP CONTAINING THE PUTATIVE GENERAL ACID ASP 92.
ChainResidue
AILE88
ALYS89
AALA90
AASN91
AASP92
ATHR93
AGLN94
AGLU95
APHE96
AASN97
ALEU98

site_idGAB
Number of Residues11
DetailsTHE LOOP CONTAINING THE PUTATIVE GENERAL ACID ASP 92.
ChainResidue
BILE88
BLYS89
BALA90
BASN91
BASP92
BTHR93
BGLN94
BGLU95
BPHE96
BASN97
BLEU98

site_idPLA
Number of Residues9
DetailsPHOSPHATE BINDING LOOP INCLUDING CATALYTIC NUCLEOPHILE CYS 130
ChainResidue
AHIS123
ACYS124
AARG125
AGLU126
AGLY127
ATYR128
ASER129
AARG130
ASER131

site_idPLB
Number of Residues9
DetailsPHOSPHATE BINDING LOOP INCLUDING CATALYTIC NUCLEOPHILE CYS 130
ChainResidue
BGLY127
BTYR128
BSER129
BARG130
BSER131
BHIS123
BCYS124
BARG125
BGLU126

site_idRCA
Number of Residues11
DetailsDESIGNATED RECOGNITION REGION IN PRIMARY REFERENCE. PROPOSED TO AFFECT SUBSTRATE SPECIFICITY.
ChainResidue
AGLY19
AGLN28
APRO29
ASER20
AGLY21
ACYS22
ATYR23
ASER24
ALEU25
APRO26
ASER27

site_idRCB
Number of Residues11
DetailsDESIGNATED RECOGNITION REGION IN PRIMARY REFERENCE. PROPOSED TO AFFECT SUBSTRATE SPECIFICITY.
ChainResidue
BGLY19
BSER20
BGLY21
BCYS22
BTYR23
BSER24
BLEU25
BPRO26
BSER27
BGLN28
BPRO29

site_idVRA
Number of Residues21
DetailsTHE REGION CONTAINING HIGH VARIATION AMONG THE DUAL-SPECIFICITY PHOSPHATASES AND THE PROTEIN TYROSINE PHOSPHATASES.
ChainResidue
AALA62
AALA63
AGLU64
AGLY65
AARG66
ASER67
APHE68
AMET69
AHIS70
AVAL71
AASN72
ATHR73
AASN74
AALA75
AASN76
APHE77
ATYR78
ALYS79
AASP80
ASER81
AGLY82

site_idVRB
Number of Residues21
DetailsTHE REGION CONTAINING HIGH VARIATION AMONG THE DUAL-SPECIFICITY PHOSPHATASES AND THE PROTEIN TYROSINE PHOSPHATASES.
ChainResidue
BALA62
BALA63
BGLU64
BGLY65
BARG66
BSER67
BPHE68
BMET69
BHIS70
BVAL71
BASN72
BTHR73
BASN74
BALA75
BASN76
BPHE77
BTYR78
BLYS79
BASP80
BSER81
BGLY82

Functional Information from PROSITE/UniProt
site_idPS00383
Number of Residues11
DetailsTYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCreGysRSP
ChainResidueDetails
AVAL122-PRO132

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160
ChainResidueDetails
ACYS124
BCYS124

218853

PDB entries from 2024-04-24

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