1VHH

A POTENTIAL CATALYTIC SITE WITHIN THE AMINO-TERMINAL SIGNALLING DOMAIN OF SONIC HEDGEHOG

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0007267	biological_process	cell-cell signaling
A	0007275	biological_process	multicellular organism development

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 400

Chain	Residue
A	HOH201
A	HIS141
A	ASP148
A	GLU177
A	HIS183
A	LYS195

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site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 401

Chain	Residue
A	ARG62
A	LYS88
A	ARG124
A	THR126
A	ARG154
A	ARG156
A	HOH221
A	HOH225

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site_id	ZN1
Number of Residues	4
Details

Chain	Residue
A	HIS141
A	ASP148
A	HIS183
A	HOH201

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	BINDING: BINDING => ECO:0000269|PubMed:18794898, ECO:0000269|PubMed:19561611, ECO:0000269|PubMed:20519495

Chain	Residue	Details
A	GLU90
A	GLU91
A	ASP96
A	THR126
A	GLU127
A	ASP130
A	ASP132

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:18794898, ECO:0000269|PubMed:19561611, ECO:0000269|PubMed:20519495, ECO:0000269|PubMed:7477329

Chain	Residue	Details
A	HIS141
A	ASP148
A	HIS183

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