1VH8

Crystal structure of a 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008299	biological_process	isoprenoid biosynthetic process
A	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A	0016114	biological_process	terpenoid biosynthetic process
A	0016829	molecular_function	lyase activity
A	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
A	0046872	molecular_function	metal ion binding
B	0008299	biological_process	isoprenoid biosynthetic process
B	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B	0016114	biological_process	terpenoid biosynthetic process
B	0016829	molecular_function	lyase activity
B	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
B	0046872	molecular_function	metal ion binding
C	0008299	biological_process	isoprenoid biosynthetic process
C	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C	0016114	biological_process	terpenoid biosynthetic process
C	0016829	molecular_function	lyase activity
C	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
C	0046872	molecular_function	metal ion binding
D	0008299	biological_process	isoprenoid biosynthetic process
D	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D	0016114	biological_process	terpenoid biosynthetic process
D	0016829	molecular_function	lyase activity
D	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
D	0046872	molecular_function	metal ion binding
E	0008299	biological_process	isoprenoid biosynthetic process
E	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E	0016114	biological_process	terpenoid biosynthetic process
E	0016829	molecular_function	lyase activity
E	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
E	0046872	molecular_function	metal ion binding
F	0008299	biological_process	isoprenoid biosynthetic process
F	0008685	molecular_function	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F	0016114	biological_process	terpenoid biosynthetic process
F	0016829	molecular_function	lyase activity
F	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
F	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE POP A 169

Chain	Residue
A	GLY139
C	PHE140
C	ARG143
C	ACY169
A	PHE140
A	ARG143
A	ACY170
B	GLY139
B	PHE140
B	ARG143
B	ACY169
C	GLY139

---

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE POP D 169

Chain	Residue
D	GLY139
D	PHE140
D	ARG143
D	ACY170
E	GLY139
E	PHE140
E	ARG143
E	ACY169
F	GLY139
F	PHE140
F	ARG143
F	ACY169

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACY A 170

Chain	Residue
A	PHE140
A	THR141
A	POP169
B	ACY169
C	ACY169

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACY B 169

Chain	Residue
A	POP169
A	ACY170
B	PHE140
B	THR141
C	ACY169

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACY C 169

Chain	Residue
A	POP169
A	ACY170
B	ACY169
C	LEU138
C	GLY139
C	PHE140
C	THR141

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACY D 170

Chain	Residue
D	PHE140
D	THR141
D	POP169
E	ACY169
F	ACY169

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACY E 169

Chain	Residue
D	POP169
D	ACY170
E	PHE140
E	THR141

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACY F 169

Chain	Residue
D	POP169
D	ACY170
F	THR135
F	LEU138
F	PHE140
F	THR141

---

Functional Information from PROSITE/UniProt

site_id	PS01350
Number of Residues	16
Details	ISPF 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase signature. SDGDVAlHAltDAilG

Chain	Residue	Details
A	SER36-GLY51

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	72
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00107","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"HAMAP-Rule","id":"MF_00107","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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