1VG0
The crystal structures of the REP-1 protein in complex with monoprenylated Rab7 protein
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005092 | molecular_function | GDP-dissociation inhibitor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005829 | cellular_component | cytosol |
| A | 0005968 | cellular_component | Rab-protein geranylgeranyltransferase complex |
| A | 0006612 | biological_process | protein targeting to membrane |
| A | 0006886 | biological_process | intracellular protein transport |
| A | 0007264 | biological_process | small GTPase-mediated signal transduction |
| A | 0016192 | biological_process | vesicle-mediated transport |
| A | 0018344 | biological_process | protein geranylgeranylation |
| A | 0031267 | molecular_function | small GTPase binding |
| A | 0044877 | molecular_function | protein-containing complex binding |
| B | 0000421 | cellular_component | autophagosome membrane |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0003925 | molecular_function | G protein activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005764 | cellular_component | lysosome |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0005770 | cellular_component | late endosome |
| B | 0005811 | cellular_component | lipid droplet |
| B | 0005829 | cellular_component | cytosol |
| B | 0008333 | biological_process | endosome to lysosome transport |
| B | 0010008 | cellular_component | endosome membrane |
| B | 0019003 | molecular_function | GDP binding |
| B | 0030670 | cellular_component | phagocytic vesicle membrane |
| B | 0030672 | cellular_component | synaptic vesicle membrane |
| B | 0031267 | molecular_function | small GTPase binding |
| B | 0031410 | cellular_component | cytoplasmic vesicle |
| B | 0031902 | cellular_component | late endosome membrane |
| B | 0031966 | cellular_component | mitochondrial membrane |
| B | 0033162 | cellular_component | melanosome membrane |
| B | 0036466 | biological_process | synaptic vesicle recycling via endosome |
| B | 0043195 | cellular_component | terminal bouton |
| B | 0045022 | biological_process | early endosome to late endosome transport |
| B | 0045335 | cellular_component | phagocytic vesicle |
| B | 0045453 | biological_process | bone resorption |
| B | 0061724 | biological_process | lipophagy |
| B | 0090383 | biological_process | phagosome acidification |
| B | 0090385 | biological_process | phagosome-lysosome fusion |
| B | 0097208 | cellular_component | alveolar lamellar body |
| B | 0098588 | cellular_component | bounding membrane of organelle |
| B | 0098830 | cellular_component | presynaptic endosome |
| B | 0099638 | biological_process | endosome to plasma membrane protein transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 3000 |
| Chain | Residue |
| B | THR22 |
| B | GDP1557 |
| B | HOH5583 |
| B | HOH5584 |
| B | HOH5585 |
| B | HOH5586 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 3001 |
| Chain | Residue |
| A | HOH3026 |
| A | TYR234 |
| A | ASN581 |
| A | HOH3012 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GER A 952 |
| Chain | Residue |
| A | PRO272 |
| A | SER274 |
| A | ARG275 |
| A | LEU292 |
| A | MET293 |
| A | VAL300 |
| A | PHE333 |
| A | LEU362 |
| site_id | AC4 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE GDP B 1557 |
| Chain | Residue |
| B | ASP16 |
| B | SER17 |
| B | GLY18 |
| B | VAL19 |
| B | GLY20 |
| B | LYS21 |
| B | THR22 |
| B | SER23 |
| B | PHE33 |
| B | ASN125 |
| B | LYS126 |
| B | ASP128 |
| B | LEU129 |
| B | SER155 |
| B | ALA156 |
| B | LYS157 |
| B | MG3000 |
| B | HOH5527 |
| B | HOH5547 |
| B | HOH5570 |
| B | HOH5583 |
| B | HOH5585 |
| B | HOH5586 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PG4 B 5502 |
| Chain | Residue |
| B | GLN71 |
| B | SER101 |
| B | TRP102 |
| B | GLU105 |
Functional Information from PROSITE/UniProt
| site_id | PS00675 |
| Number of Residues | 14 |
| Details | SIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. VIIlGDSGVGKtsL |
| Chain | Residue | Details |
| B | VAL11-LEU24 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 15 |
| Details | Motif: {"description":"Switch 2","evidences":[{"source":"UniProtKB","id":"P51149","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P51149","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P51149","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| B | GLN67 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| B | GLY18 |
