1VFN
PURINE NUCLEOSIDE PHOSPHORYLASE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0047975 | molecular_function | guanosine phosphorylase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 301 |
| Chain | Residue |
| A | HOH335 |
| A | HOH345 |
| A | HOH346 |
| A | HOH347 |
| A | HOH348 |
| A | HOH349 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 434 |
| Chain | Residue |
| A | HIS20 |
| A | HIS20 |
| A | HIS20 |
| A | HOH433 |
| A | HOH433 |
| A | HOH433 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE HPA A 300 |
| Chain | Residue |
| A | ALA116 |
| A | ALA117 |
| A | GLY118 |
| A | PHE200 |
| A | GLU201 |
| A | VAL217 |
| A | GLY218 |
| A | THR242 |
| A | ASN243 |
| A | LYS244 |
| A | HOH302 |
| A | HOH342 |
| site_id | BAS |
| Number of Residues | 4 |
| Details | BASE BINDING SITE. |
| Chain | Residue |
| A | GLU201 |
| A | ASN243 |
| A | HOH302 |
| A | HOH342 |
| site_id | PRE |
| Number of Residues | 11 |
| Details | PHOSPHATE BINDING SITE. |
| Chain | Residue |
| A | SER220 |
| A | HOH342 |
| A | HOH425 |
| A | HOH418 |
| A | HOH328 |
| A | HOH389 |
| A | TYR88 |
| A | ARG84 |
| A | ALA116 |
| A | PRO92 |
| A | MET219 |
Functional Information from PROSITE/UniProt
| site_id | PS01240 |
| Number of Residues | 42 |
| Details | PNP_MTAP_2 Purine and other phosphorylases family 2 signature. VmmqGrfHmYegypFwkvTfpVrVfrllGvet.LVvtNAaGGL |
| Chain | Residue | Details |
| A | VAL79-LEU120 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9585525","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A9O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1A9P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1A9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1A9T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PNP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9585525","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A9O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1A9P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1A9Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1A9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1A9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1A9T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PNP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9585525","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A9P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1A9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1A9T","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9585525","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9020983","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1A9P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1A9Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1A9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for substrate specificity","evidences":[{"source":"UniProtKB","id":"P00491","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P00491","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1cg6 |
| Chain | Residue | Details |
| A | ASN243 | |
| A | HIS86 | |
| A | GLU89 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1cg6 |
| Chain | Residue | Details |
| A | ASN243 | |
| A | ASP248 |
