1VCN

Crystal Structure of T.th. HB8 CTP synthetase complex with Sulfate anion

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003883	molecular_function	CTP synthase activity
A	0004359	molecular_function	glutaminase activity
A	0005524	molecular_function	ATP binding
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006241	biological_process	CTP biosynthetic process
A	0006541	biological_process	glutamine metabolic process
A	0016874	molecular_function	ligase activity
A	0044210	biological_process	'de novo' CTP biosynthetic process
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 610

Chain	Residue
A	LYS27
A	LYS49
A	GLU151
A	GLY153
A	GLY154
A	HOH644
A	HOH873

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site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 620

Chain	Residue
A	GLY26
A	LYS27
A	GLY28
A	HOH637
A	HOH638
A	HOH648
A	SER24
A	LEU25

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 630

Chain	Residue
A	LYS198
A	THR199
A	LYS200
A	LYS234
A	HOH662
A	HOH719

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Nucleophile; for glutamine hydrolysis => ECO:0000255|HAMAP-Rule:MF_01227, ECO:0000305|PubMed:15296735

Chain	Residue	Details
A	CYS391

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_01227, ECO:0000305|PubMed:15296735

Chain	Residue	Details
A	HIS522
A	GLU524

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01227

Chain	Residue	Details
A	SER23
A	SER24
A	ASP81
A	GLU151
A	ASP158
A	LYS198
A	LYS234
A	VAL252

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:15296735, ECO:0007744|PDB:1VCO

Chain	Residue	Details
A	TYR64
A	GLY364
A	LEU392
A	GLU415
A	ARG472

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
A	CYS391
A	HIS522
A	GLU524

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
A	CYS391
A	HIS522

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