Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1V7Z

creatininase-product complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006601	biological_process	creatine biosynthetic process
A	0006602	biological_process	creatinine catabolic process
A	0008270	molecular_function	zinc ion binding
A	0009231	biological_process	riboflavin biosynthetic process
A	0016787	molecular_function	hydrolase activity
A	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
A	0030145	molecular_function	manganese ion binding
A	0046872	molecular_function	metal ion binding
A	0047789	molecular_function	creatininase activity
B	0006601	biological_process	creatine biosynthetic process
B	0006602	biological_process	creatinine catabolic process
B	0008270	molecular_function	zinc ion binding
B	0009231	biological_process	riboflavin biosynthetic process
B	0016787	molecular_function	hydrolase activity
B	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
B	0030145	molecular_function	manganese ion binding
B	0046872	molecular_function	metal ion binding
B	0047789	molecular_function	creatininase activity
C	0006601	biological_process	creatine biosynthetic process
C	0006602	biological_process	creatinine catabolic process
C	0008270	molecular_function	zinc ion binding
C	0009231	biological_process	riboflavin biosynthetic process
C	0016787	molecular_function	hydrolase activity
C	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
C	0030145	molecular_function	manganese ion binding
C	0046872	molecular_function	metal ion binding
C	0047789	molecular_function	creatininase activity
D	0006601	biological_process	creatine biosynthetic process
D	0006602	biological_process	creatinine catabolic process
D	0008270	molecular_function	zinc ion binding
D	0009231	biological_process	riboflavin biosynthetic process
D	0016787	molecular_function	hydrolase activity
D	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
D	0030145	molecular_function	manganese ion binding
D	0046872	molecular_function	metal ion binding
D	0047789	molecular_function	creatininase activity
E	0006601	biological_process	creatine biosynthetic process
E	0006602	biological_process	creatinine catabolic process
E	0008270	molecular_function	zinc ion binding
E	0009231	biological_process	riboflavin biosynthetic process
E	0016787	molecular_function	hydrolase activity
E	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
E	0030145	molecular_function	manganese ion binding
E	0046872	molecular_function	metal ion binding
E	0047789	molecular_function	creatininase activity
F	0006601	biological_process	creatine biosynthetic process
F	0006602	biological_process	creatinine catabolic process
F	0008270	molecular_function	zinc ion binding
F	0009231	biological_process	riboflavin biosynthetic process
F	0016787	molecular_function	hydrolase activity
F	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
F	0030145	molecular_function	manganese ion binding
F	0046872	molecular_function	metal ion binding
F	0047789	molecular_function	creatininase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 300

Chain	Residue
A	GLU34
A	ASP45
A	HIS120
A	ZN301
A	CRN401
A	HOH1001

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 301

Chain	Residue
A	MN300
A	CRN401
A	HIS36
A	ASP45
A	GLU183

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN B 3300

Chain	Residue
B	GLU34
B	ASP45
B	HIS120
B	HOH1003
B	ZN3301
B	CRN3401

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 3301

Chain	Residue
B	HIS36
B	ASP45
B	GLU183
B	MN3300
B	CRN3401

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN C 4300

Chain	Residue
C	GLU34
C	ASP45
C	HIS120
C	HOH1005
C	ZN4301
C	CRN4401

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 4301

Chain	Residue
C	HIS36
C	ASP45
C	GLU183
C	MN4300
C	CRN4401

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN D 5300

Chain	Residue
D	GLU34
D	ASP45
D	HIS120
D	HOH1007
D	ZN5301
D	CRN5401

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN D 5301

Chain	Residue
D	HIS36
D	ASP45
D	GLU183
D	MN5300
D	CRN5401

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN E 6300

Chain	Residue
E	GLU34
E	ASP45
E	HIS120
E	HOH1009
E	ZN6301
E	CRN6401

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN E 6301

Chain	Residue
E	HIS36
E	ASP45
E	GLU183
E	MN6300
E	CRN6401

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN F 7300

Chain	Residue
F	GLU34
F	ASP45
F	HIS120
F	HOH1011
F	ZN7301
F	CRN7401

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN F 7301

Chain	Residue
F	HIS36
F	ASP45
F	GLU183
F	MN7300
F	CRN7401

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 501

Chain	Residue
A	LYS54
A	ARG55
A	TYR191
A	HOH1158
A	HOH1732
A	HOH2649
A	HOH2699

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 502

Chain	Residue
A	ARG59
A	GLN247
A	ARG254
A	HOH2407
A	HOH2754

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 503

Chain	Residue
A	ARG113
A	LYS147
A	GLU256
A	PHE257
A	HOH1819

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 3501

Chain	Residue
B	LYS54
B	ARG55
B	TYR191
B	HOH1136
B	HOH1841

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 3502

Chain	Residue
B	ARG59
B	GLN247
B	ARG254
B	HOH2247

site_id	BC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 3503

Chain	Residue
B	ARG113
B	LYS147
B	GLU256
B	PHE257
B	HOH1592
B	HOH2365
B	HOH2378

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 4501

Chain	Residue
C	LYS54
C	ARG55
C	TYR191
C	HOH1166
C	HOH1959

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 4502

Chain	Residue
C	ARG59
C	GLN247
C	ARG254

site_id	CC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 4503

Chain	Residue
C	ARG113
C	LYS147
C	GLU256
C	PHE257
C	PRO258
C	HOH1480
C	HOH2715

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 5501

Chain	Residue
D	LYS54
D	ARG55
D	TYR191
D	HOH1398
D	HOH2278
D	HOH2558

site_id	CC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 5502

Chain	Residue
D	ARG59
D	GLN247
D	ARG254

site_id	CC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 5503

Chain	Residue
D	ARG113
D	LYS147
D	GLU256
D	PHE257
D	HOH1736
D	HOH2369

site_id	CC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 6501

Chain	Residue
E	LYS54
E	ARG55
E	TYR191
E	HOH1375
E	HOH2743

site_id	CC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 6502

Chain	Residue
E	ARG59
E	GLN247
E	ARG254

site_id	CC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 6503

Chain	Residue
E	ARG113
E	LYS147
E	GLU256
E	PHE257
E	HOH1424

site_id	DC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 F 7501

Chain	Residue
F	LYS54
F	ARG55
F	TYR191
F	HOH1174
F	HOH1903
F	HOH2400

site_id	DC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 F 7502

Chain	Residue
F	ARG59
F	GLN247
F	ARG254

site_id	DC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 F 7503

Chain	Residue
F	ARG113
F	LYS147
F	GLU256
F	PHE257
F	HOH1579
F	HOH1979
F	HOH2493

site_id	DC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE CRN A 401

Chain	Residue
A	GLU34
A	HIS36
A	ASP45
A	SER78
A	GLY119
A	HIS120
A	TYR121
A	TRP174
A	ASP175
A	GLU177
A	HIS178
A	GLU183
A	MN300
A	ZN301
A	HOH1001

site_id	DC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE CRN B 3401

Chain	Residue
B	GLU34
B	HIS36
B	ASP45
B	SER78
B	HIS120
B	TYR121
B	TRP174
B	ASP175
B	GLU177
B	HIS178
B	GLU183
B	HOH1003
B	HOH2653
B	MN3300
B	ZN3301

site_id	DC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE CRN C 4401

Chain	Residue
C	GLU34
C	HIS36
C	ASP45
C	SER78
C	GLY119
C	HIS120
C	TYR121
C	TRP174
C	GLU177
C	HIS178
C	GLU183
C	HOH1005
C	MN4300
C	ZN4301

site_id	DC7
Number of Residues	16
Details	BINDING SITE FOR RESIDUE CRN D 5401

Chain	Residue
D	GLU34
D	HIS36
D	ASP45
D	SER78
D	GLY119
D	HIS120
D	TYR121
D	TRP154
D	TRP174
D	ASP175
D	GLU177
D	HIS178
D	GLU183
D	HOH1007
D	MN5300
D	ZN5301

site_id	DC8
Number of Residues	16
Details	BINDING SITE FOR RESIDUE CRN E 6401

Chain	Residue
E	GLU34
E	HIS36
E	ASP45
E	SER78
E	GLY119
E	HIS120
E	TYR121
E	TRP154
E	TRP174
E	ASP175
E	GLU177
E	HIS178
E	GLU183
E	HOH1009
E	MN6300
E	ZN6301

site_id	DC9
Number of Residues	15
Details	BINDING SITE FOR RESIDUE CRN F 7401

Chain	Residue
F	GLU34
F	HIS36
F	ASP45
F	SER78
F	GLY119
F	HIS120
F	TYR121
F	TRP174
F	ASP175
F	GLU177
F	HIS178
F	GLU183
F	HOH1011
F	MN7300
F	ZN7301

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12946365","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20043918","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3A6L","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12946365","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15003455","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20043918","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1V7Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3A6J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3A6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3A6L","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15003455","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20043918","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1V7Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3A6J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	6
Details	Site: {"description":"Coordinates a catalytic water molecule"}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	7
Details	M-CSA 720

Chain	Residue	Details
A	GLU34	metal ligand
A	HIS36	metal ligand
A	ASP45	metal ligand
A	HIS120	metal ligand
A	GLU122	electrostatic stabiliser
A	HIS178	proton acceptor, proton donor
A	GLU183	metal ligand

site_id	MCSA2
Number of Residues	7
Details	M-CSA 720

Chain	Residue	Details
B	GLU34	metal ligand
B	HIS36	metal ligand
B	ASP45	metal ligand
B	HIS120	metal ligand
B	GLU122	electrostatic stabiliser
B	HIS178	proton acceptor, proton donor
B	GLU183	metal ligand

site_id	MCSA3
Number of Residues	7
Details	M-CSA 720

Chain	Residue	Details
C	GLU34	metal ligand
C	HIS36	metal ligand
C	ASP45	metal ligand
C	HIS120	metal ligand
C	GLU122	electrostatic stabiliser
C	HIS178	proton acceptor, proton donor
C	GLU183	metal ligand

site_id	MCSA4
Number of Residues	7
Details	M-CSA 720

Chain	Residue	Details
D	GLU34	metal ligand
D	HIS36	metal ligand
D	ASP45	metal ligand
D	HIS120	metal ligand
D	GLU122	electrostatic stabiliser
D	HIS178	proton acceptor, proton donor
D	GLU183	metal ligand

site_id	MCSA5
Number of Residues	7
Details	M-CSA 720

Chain	Residue	Details
E	GLU34	metal ligand
E	HIS36	metal ligand
E	ASP45	metal ligand
E	HIS120	metal ligand
E	GLU122	electrostatic stabiliser
E	HIS178	proton acceptor, proton donor
E	GLU183	metal ligand

site_id	MCSA6
Number of Residues	7
Details	M-CSA 720

Chain	Residue	Details
F	GLU34	metal ligand
F	HIS36	metal ligand
F	ASP45	metal ligand
F	HIS120	metal ligand
F	GLU122	electrostatic stabiliser
F	HIS178	proton acceptor, proton donor
F	GLU183	metal ligand

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)