1V55
Bovine heart cytochrome c oxidase at the fully reduced state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004129 | molecular_function | cytochrome-c oxidase activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0006119 | biological_process | oxidative phosphorylation |
| A | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| A | 0009060 | biological_process | aerobic respiration |
| A | 0015990 | biological_process | electron transport coupled proton transport |
| A | 0016020 | cellular_component | membrane |
| A | 0020037 | molecular_function | heme binding |
| A | 0045277 | cellular_component | respiratory chain complex IV |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004129 | molecular_function | cytochrome-c oxidase activity |
| B | 0005507 | molecular_function | copper ion binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005743 | cellular_component | mitochondrial inner membrane |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0022900 | biological_process | electron transport chain |
| B | 0042773 | biological_process | ATP synthesis coupled electron transport |
| B | 0045277 | cellular_component | respiratory chain complex IV |
| B | 0046872 | molecular_function | metal ion binding |
| B | 1902600 | biological_process | proton transmembrane transport |
| C | 0004129 | molecular_function | cytochrome-c oxidase activity |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005743 | cellular_component | mitochondrial inner membrane |
| C | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| C | 0008535 | biological_process | respiratory chain complex IV assembly |
| C | 0009055 | molecular_function | electron transfer activity |
| C | 0016020 | cellular_component | membrane |
| C | 0019646 | biological_process | aerobic electron transport chain |
| C | 0022904 | biological_process | respiratory electron transport chain |
| C | 0045277 | cellular_component | respiratory chain complex IV |
| C | 1902600 | biological_process | proton transmembrane transport |
| D | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| D | 0045277 | cellular_component | respiratory chain complex IV |
| E | 0005743 | cellular_component | mitochondrial inner membrane |
| E | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| E | 0045277 | cellular_component | respiratory chain complex IV |
| F | 0005740 | cellular_component | mitochondrial envelope |
| F | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| F | 0045277 | cellular_component | respiratory chain complex IV |
| G | 0005743 | cellular_component | mitochondrial inner membrane |
| H | 0005739 | cellular_component | mitochondrion |
| H | 0005743 | cellular_component | mitochondrial inner membrane |
| H | 0006119 | biological_process | oxidative phosphorylation |
| H | 0045277 | cellular_component | respiratory chain complex IV |
| I | 0005739 | cellular_component | mitochondrion |
| I | 0005743 | cellular_component | mitochondrial inner membrane |
| I | 0006119 | biological_process | oxidative phosphorylation |
| I | 0045277 | cellular_component | respiratory chain complex IV |
| J | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| J | 0045277 | cellular_component | respiratory chain complex IV |
| K | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| L | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| L | 0045277 | cellular_component | respiratory chain complex IV |
| M | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| M | 0045277 | cellular_component | respiratory chain complex IV |
| N | 0004129 | molecular_function | cytochrome-c oxidase activity |
| N | 0005739 | cellular_component | mitochondrion |
| N | 0005743 | cellular_component | mitochondrial inner membrane |
| N | 0006119 | biological_process | oxidative phosphorylation |
| N | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| N | 0009060 | biological_process | aerobic respiration |
| N | 0015990 | biological_process | electron transport coupled proton transport |
| N | 0016020 | cellular_component | membrane |
| N | 0020037 | molecular_function | heme binding |
| N | 0045277 | cellular_component | respiratory chain complex IV |
| N | 0046872 | molecular_function | metal ion binding |
| O | 0004129 | molecular_function | cytochrome-c oxidase activity |
| O | 0005507 | molecular_function | copper ion binding |
| O | 0005739 | cellular_component | mitochondrion |
| O | 0005743 | cellular_component | mitochondrial inner membrane |
| O | 0016020 | cellular_component | membrane |
| O | 0016491 | molecular_function | oxidoreductase activity |
| O | 0022900 | biological_process | electron transport chain |
| O | 0042773 | biological_process | ATP synthesis coupled electron transport |
| O | 0045277 | cellular_component | respiratory chain complex IV |
| O | 0046872 | molecular_function | metal ion binding |
| O | 1902600 | biological_process | proton transmembrane transport |
| P | 0004129 | molecular_function | cytochrome-c oxidase activity |
| P | 0005739 | cellular_component | mitochondrion |
| P | 0005743 | cellular_component | mitochondrial inner membrane |
| P | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| P | 0008535 | biological_process | respiratory chain complex IV assembly |
| P | 0009055 | molecular_function | electron transfer activity |
| P | 0016020 | cellular_component | membrane |
| P | 0019646 | biological_process | aerobic electron transport chain |
| P | 0022904 | biological_process | respiratory electron transport chain |
| P | 0045277 | cellular_component | respiratory chain complex IV |
| P | 1902600 | biological_process | proton transmembrane transport |
| Q | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| Q | 0045277 | cellular_component | respiratory chain complex IV |
| R | 0005743 | cellular_component | mitochondrial inner membrane |
| R | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| R | 0045277 | cellular_component | respiratory chain complex IV |
| S | 0005740 | cellular_component | mitochondrial envelope |
| S | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| S | 0045277 | cellular_component | respiratory chain complex IV |
| T | 0005743 | cellular_component | mitochondrial inner membrane |
| U | 0005739 | cellular_component | mitochondrion |
| U | 0005743 | cellular_component | mitochondrial inner membrane |
| U | 0006119 | biological_process | oxidative phosphorylation |
| U | 0045277 | cellular_component | respiratory chain complex IV |
| V | 0005739 | cellular_component | mitochondrion |
| V | 0005743 | cellular_component | mitochondrial inner membrane |
| V | 0006119 | biological_process | oxidative phosphorylation |
| V | 0045277 | cellular_component | respiratory chain complex IV |
| W | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| W | 0045277 | cellular_component | respiratory chain complex IV |
| X | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| Y | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| Y | 0045277 | cellular_component | respiratory chain complex IV |
| Z | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| Z | 0045277 | cellular_component | respiratory chain complex IV |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CU A 517 |
| Chain | Residue |
| A | HIS240 |
| A | HIS290 |
| A | HIS291 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 3518 |
| Chain | Residue |
| A | HIS368 |
| A | ASP369 |
| B | GLU198 |
| B | HOH4091 |
| B | HOH4092 |
| B | HOH4093 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 3519 |
| Chain | Residue |
| A | GLU40 |
| A | GLY45 |
| A | SER441 |
| A | HOH3544 |
| site_id | AC4 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE HEA A 515 |
| Chain | Residue |
| A | ALA24 |
| A | MET28 |
| A | THR31 |
| A | SER34 |
| A | ILE37 |
| A | ARG38 |
| A | TYR54 |
| A | VAL58 |
| A | HIS61 |
| A | ALA62 |
| A | MET65 |
| A | ILE66 |
| A | VAL70 |
| A | ILE73 |
| A | GLY125 |
| A | TRP126 |
| A | TYR371 |
| A | PHE377 |
| A | HIS378 |
| A | SER382 |
| A | PHE425 |
| A | GLN428 |
| A | ARG438 |
| A | ARG439 |
| A | VAL465 |
| A | HOH3528 |
| A | HOH3548 |
| A | HOH3571 |
| site_id | AC5 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE HEA A 516 |
| Chain | Residue |
| A | TRP126 |
| A | TRP236 |
| A | VAL243 |
| A | TYR244 |
| A | ILE247 |
| A | HIS290 |
| A | HIS291 |
| A | THR309 |
| A | ILE312 |
| A | THR316 |
| A | GLY317 |
| A | GLY352 |
| A | GLY355 |
| A | LEU358 |
| A | ALA359 |
| A | ASP364 |
| A | HIS368 |
| A | VAL373 |
| A | HIS376 |
| A | PHE377 |
| A | VAL380 |
| A | LEU381 |
| A | ARG438 |
| A | HOH3529 |
| A | HOH3536 |
| A | HOH3546 |
| A | HOH3554 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE TGL A 3521 |
| Chain | Residue |
| A | VAL350 |
| A | ASN422 |
| A | PHE426 |
| A | PHE430 |
| A | LEU433 |
| A | HOH3642 |
| B | LEU7 |
| B | GLY8 |
| B | LEU28 |
| B | VAL31 |
| B | SER35 |
| B | LEU39 |
| D | HOH210 |
| I | ARG43 |
| I | HOH346 |
| site_id | AC7 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE TGL A 3522 |
| Chain | Residue |
| L | HOH2344 |
| A | PHE2 |
| A | THR17 |
| A | LEU20 |
| A | LEU21 |
| A | TRP81 |
| A | LEU113 |
| A | PHE400 |
| A | ILE472 |
| L | ASN10 |
| L | ILE11 |
| L | PRO12 |
| L | PHE13 |
| L | SER14 |
| L | ARG20 |
| L | MET24 |
| L | SER31 |
| site_id | AC8 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE TGL A 3523 |
| Chain | Residue |
| A | TRP334 |
| A | MET339 |
| A | LEU342 |
| A | GLY343 |
| A | PHE414 |
| A | HOH3671 |
| A | HOH3753 |
| B | ILE42 |
| B | THR47 |
| D | ARG73 |
| D | GLU77 |
| D | TRP78 |
| D | VAL81 |
| D | ILE89 |
| site_id | AC9 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE PGV A 3266 |
| Chain | Residue |
| A | PHE94 |
| A | PRO95 |
| A | ARG96 |
| A | MET97 |
| A | HOH3708 |
| C | HIS9 |
| C | ASN50 |
| C | TRP57 |
| C | TRP58 |
| C | GLU64 |
| C | HIS71 |
| C | LEU79 |
| C | GLY82 |
| site_id | BC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE PGV A 3524 |
| Chain | Residue |
| A | ASN406 |
| A | THR408 |
| A | HOH3743 |
| A | HOH3752 |
| D | ALA84 |
| D | PHE87 |
| D | PHE88 |
| K | HIS10 |
| M | GLN15 |
| M | ALA16 |
| M | LEU19 |
| M | SER20 |
| M | HOH2318 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CUA B 228 |
| Chain | Residue |
| B | HIS161 |
| B | CYS196 |
| B | GLU198 |
| B | CYS200 |
| B | HIS204 |
| B | MET207 |
| site_id | BC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CHD B 4085 |
| Chain | Residue |
| A | MET271 |
| B | GLN59 |
| B | GLU62 |
| B | THR63 |
| B | HOH4143 |
| B | HOH4236 |
| B | HOH4252 |
| P | PEK4265 |
| T | ARG14 |
| T | ARG17 |
| T | GLY22 |
| T | HOH1509 |
| site_id | BC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CHD C 3525 |
| Chain | Residue |
| A | HIS233 |
| A | ASP300 |
| A | THR301 |
| A | TYR304 |
| A | HOH3533 |
| C | TRP99 |
| C | HIS103 |
| C | PGV3268 |
| site_id | BC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CHD C 3271 |
| Chain | Residue |
| C | ARG156 |
| C | LEU160 |
| C | GLN161 |
| C | PHE164 |
| C | LEU223 |
| C | HOH3628 |
| J | PHE1 |
| site_id | BC6 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE CDL C 3270 |
| Chain | Residue |
| C | MET51 |
| C | TYR55 |
| C | TRP58 |
| C | ARG59 |
| C | ARG63 |
| C | PHE67 |
| C | THR213 |
| C | LYS224 |
| C | HIS226 |
| C | PGV3267 |
| C | HOH3618 |
| J | LYS8 |
| J | HOH2651 |
| site_id | BC7 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE PEK C 3264 |
| Chain | Residue |
| A | HIS151 |
| C | TRP34 |
| C | TYR181 |
| C | TYR182 |
| C | ALA184 |
| C | PHE186 |
| C | THR187 |
| C | ILE188 |
| C | PHE198 |
| C | GLY202 |
| G | TRP62 |
| G | THR68 |
| G | PHE69 |
| G | PHE70 |
| G | HIS71 |
| G | ASN76 |
| G | HOH2048 |
| site_id | BC8 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE PEK C 3265 |
| Chain | Residue |
| C | LYS157 |
| C | HIS158 |
| C | GLN161 |
| C | LEU169 |
| C | TYR172 |
| F | ALA1 |
| G | ARG17 |
| G | PHE21 |
| G | CDL3269 |
| N | SER279 |
| O | GLN59 |
| O | THR66 |
| O | CHD3085 |
| site_id | BC9 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE PGV C 3267 |
| Chain | Residue |
| C | TRP58 |
| C | VAL61 |
| C | ILE62 |
| C | SER65 |
| C | THR66 |
| C | ILE210 |
| C | THR213 |
| C | PHE214 |
| C | ARG221 |
| C | HIS226 |
| C | PHE227 |
| C | THR228 |
| C | HIS231 |
| C | HIS232 |
| C | PHE233 |
| C | GLY234 |
| C | CDL3270 |
| C | HOH3561 |
| C | HOH3591 |
| F | HOH105 |
| site_id | CC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PGV C 3268 |
| Chain | Residue |
| A | HOH3691 |
| C | THR95 |
| C | TRP99 |
| C | TYR102 |
| C | HIS103 |
| C | CHD3525 |
| C | HOH3603 |
| C | HOH3631 |
| site_id | CC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE UNX C 3262 |
| Chain | Residue |
| C | HIS148 |
| C | HIS232 |
| C | GLU236 |
| C | HOH3526 |
| site_id | CC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PSC E 3230 |
| Chain | Residue |
| A | PHE321 |
| A | HOH3727 |
| B | ILE41 |
| B | HIS52 |
| B | MET56 |
| B | ASP57 |
| B | VAL61 |
| B | TRP65 |
| B | LEU68 |
| E | HIS5 |
| E | ASP8 |
| E | PHE11 |
| I | ARG10 |
| I | ALA14 |
| site_id | CC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN F 99 |
| Chain | Residue |
| F | CYS60 |
| F | CYS62 |
| F | CYS82 |
| F | CYS85 |
| site_id | CC5 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE CDL G 3269 |
| Chain | Residue |
| C | LEU127 |
| C | LEU131 |
| C | SER135 |
| C | LEU138 |
| C | VAL142 |
| C | LEU250 |
| C | TYR253 |
| C | VAL254 |
| C | TRP258 |
| C | PEK3265 |
| G | LEU23 |
| G | SER27 |
| G | LEU30 |
| G | CYS31 |
| G | ASN34 |
| G | LEU37 |
| G | HIS38 |
| G | HOH2557 |
| N | PHE282 |
| N | ILE286 |
| N | ASP300 |
| N | TYR304 |
| N | SER307 |
| N | ILE311 |
| O | ALA77 |
| O | LEU78 |
| O | LEU81 |
| O | TYR85 |
| O | HOH1358 |
| P | PGV4268 |
| site_id | CC6 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PEK G 4263 |
| Chain | Residue |
| G | SER2 |
| G | ALA3 |
| G | LYS5 |
| G | GLY6 |
| G | HIS8 |
| G | TPO11 |
| P | LYS77 |
| P | ARG80 |
| P | TYR81 |
| P | ILE84 |
| P | PHE98 |
| P | TRP240 |
| P | PHE244 |
| P | VAL247 |
| site_id | CC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CHD J 3060 |
| Chain | Residue |
| J | ARG33 |
| J | MET36 |
| J | THR37 |
| J | LEU40 |
| site_id | CC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMU M 3526 |
| Chain | Residue |
| D | TRP98 |
| M | LEU27 |
| M | LEU28 |
| M | GLY31 |
| M | TRP32 |
| M | TYR35 |
| M | HIS36 |
| site_id | CC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CU N 517 |
| Chain | Residue |
| N | HIS240 |
| N | HIS290 |
| N | HIS291 |
| site_id | DC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG N 4518 |
| Chain | Residue |
| N | HIS368 |
| N | ASP369 |
| O | GLU198 |
| O | HOH1031 |
| O | HOH1032 |
| O | HOH1033 |
| site_id | DC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA N 4519 |
| Chain | Residue |
| N | GLU40 |
| N | GLY45 |
| N | SER441 |
| N | HOH1026 |
| site_id | DC3 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE HEA N 515 |
| Chain | Residue |
| N | THR31 |
| N | SER34 |
| N | ILE37 |
| N | ARG38 |
| N | TYR54 |
| N | VAL58 |
| N | HIS61 |
| N | ALA62 |
| N | MET65 |
| N | VAL70 |
| N | GLY125 |
| N | TRP126 |
| N | TYR371 |
| N | PHE377 |
| N | HIS378 |
| N | SER382 |
| N | PHE393 |
| N | PHE425 |
| N | GLN428 |
| N | ARG438 |
| N | ARG439 |
| N | VAL465 |
| N | HOH1005 |
| N | HOH1036 |
| N | HOH1072 |
| site_id | DC4 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE HEA N 516 |
| Chain | Residue |
| N | TRP126 |
| N | TRP236 |
| N | VAL243 |
| N | TYR244 |
| N | ILE247 |
| N | HIS290 |
| N | HIS291 |
| N | THR309 |
| N | THR316 |
| N | GLY317 |
| N | GLY352 |
| N | GLY355 |
| N | ILE356 |
| N | LEU358 |
| N | ALA359 |
| N | ASP364 |
| N | HIS368 |
| N | VAL373 |
| N | HIS376 |
| N | PHE377 |
| N | VAL380 |
| N | LEU381 |
| N | ARG438 |
| N | HOH1007 |
| N | HOH1016 |
| N | HOH1034 |
| N | HOH1044 |
| O | ILE34 |
| site_id | DC5 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE TGL N 4521 |
| Chain | Residue |
| N | VAL350 |
| N | ASN422 |
| N | PHE426 |
| N | PHE430 |
| N | LEU433 |
| N | HOH1262 |
| O | LEU7 |
| O | GLY8 |
| O | LEU28 |
| O | VAL31 |
| O | PHE32 |
| O | SER35 |
| O | LEU39 |
| Q | HOH1346 |
| V | ARG43 |
| site_id | DC6 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE TGL N 4522 |
| Chain | Residue |
| N | PHE2 |
| N | THR17 |
| N | LEU20 |
| N | LEU21 |
| N | PHE22 |
| N | TRP81 |
| N | LEU113 |
| N | PHE393 |
| N | PHE400 |
| N | ILE472 |
| Y | ASN10 |
| Y | ILE11 |
| Y | PRO12 |
| Y | PHE13 |
| Y | SER14 |
| Y | MET24 |
| Y | PHE29 |
| Y | SER31 |
| site_id | DC7 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE PGV N 4266 |
| Chain | Residue |
| N | PHE94 |
| N | PRO95 |
| N | ARG96 |
| N | MET97 |
| N | MET100 |
| N | HOH1467 |
| N | HOH2013 |
| P | HIS9 |
| P | ASN50 |
| P | MET54 |
| P | TRP57 |
| P | TRP58 |
| P | GLU64 |
| P | HIS71 |
| P | LEU79 |
| P | GLY82 |
| site_id | DC8 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PGV N 4524 |
| Chain | Residue |
| N | ASN406 |
| N | THR408 |
| N | TRP409 |
| N | HOH2100 |
| Q | ALA84 |
| Q | PHE87 |
| Z | PRO12 |
| Z | GLN15 |
| Z | ALA16 |
| Z | LEU19 |
| Z | SER20 |
| Z | HOH2192 |
| site_id | DC9 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CHD O 3085 |
| Chain | Residue |
| C | PEK3265 |
| G | ARG14 |
| G | ARG17 |
| G | GLY22 |
| G | HOH2008 |
| N | MET271 |
| O | GLN59 |
| O | GLU62 |
| O | THR63 |
| O | HOH1345 |
| O | HOH2247 |
| O | HOH2402 |
| site_id | EC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE PSC O 4230 |
| Chain | Residue |
| N | PHE321 |
| O | ILE41 |
| O | HIS52 |
| O | MET56 |
| O | ASP57 |
| O | VAL61 |
| O | TRP65 |
| O | LEU68 |
| R | HIS5 |
| R | GLU6 |
| R | ASP8 |
| R | PHE11 |
| V | ARG10 |
| site_id | EC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CUA O 228 |
| Chain | Residue |
| O | HIS161 |
| O | CYS196 |
| O | GLU198 |
| O | CYS200 |
| O | HIS204 |
| O | MET207 |
| site_id | EC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CHD P 4525 |
| Chain | Residue |
| N | HIS233 |
| N | ASP300 |
| N | THR301 |
| N | TYR304 |
| P | TRP99 |
| P | HIS103 |
| P | HOH2536 |
| P | PGV4268 |
| site_id | EC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CHD P 4271 |
| Chain | Residue |
| P | ARG156 |
| P | LEU160 |
| P | PHE164 |
| P | LEU223 |
| W | PHE1 |
| site_id | EC5 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE CDL P 4270 |
| Chain | Residue |
| P | MET51 |
| P | TYR55 |
| P | TRP58 |
| P | ARG59 |
| P | ARG63 |
| P | PHE67 |
| P | THR213 |
| P | LYS224 |
| P | HIS226 |
| P | HOH2392 |
| P | HOH2598 |
| P | HOH2645 |
| P | PGV4267 |
| W | LYS8 |
| site_id | EC6 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE PEK P 4264 |
| Chain | Residue |
| N | HIS151 |
| P | TRP34 |
| P | TYR181 |
| P | TYR182 |
| P | ALA184 |
| P | PHE186 |
| P | THR187 |
| P | ILE188 |
| P | PHE198 |
| P | GLY202 |
| T | TRP62 |
| T | THR68 |
| T | PHE69 |
| T | PHE70 |
| T | HIS71 |
| T | ASN76 |
| T | HOH1494 |
| site_id | EC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PEK P 4265 |
| Chain | Residue |
| A | SER279 |
| B | GLN59 |
| B | CHD4085 |
| P | LYS157 |
| P | HIS158 |
| P | GLN161 |
| P | LEU169 |
| S | ALA1 |
| T | ARG17 |
| T | CDL4269 |
| site_id | EC8 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE PGV P 4267 |
| Chain | Residue |
| P | TRP58 |
| P | VAL61 |
| P | SER65 |
| P | THR66 |
| P | HIS207 |
| P | ILE210 |
| P | THR213 |
| P | PHE214 |
| P | ARG221 |
| P | HIS226 |
| P | PHE227 |
| P | HIS231 |
| P | HIS232 |
| P | PHE233 |
| P | GLY234 |
| P | HOH1321 |
| P | HOH2011 |
| P | CDL4270 |
| S | HOH1121 |
| site_id | EC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGV P 4268 |
| Chain | Residue |
| G | CDL3269 |
| N | ASP298 |
| P | THR95 |
| P | HIS103 |
| P | HOH2400 |
| P | CHD4525 |
| site_id | FC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE UNX P 4262 |
| Chain | Residue |
| P | HIS148 |
| P | HIS232 |
| P | GLU236 |
| P | HOH1027 |
| site_id | FC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE TGL Q 4523 |
| Chain | Residue |
| N | TRP334 |
| N | MET339 |
| N | LEU342 |
| N | GLY343 |
| N | PHE414 |
| O | ILE42 |
| O | THR47 |
| O | LYS49 |
| Q | ARG73 |
| Q | GLU77 |
| Q | TRP78 |
| Q | VAL81 |
| Q | ILE89 |
| Q | HOH1368 |
| site_id | FC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN S 99 |
| Chain | Residue |
| S | CYS60 |
| S | CYS62 |
| S | CYS82 |
| S | CYS85 |
| site_id | FC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE PEK T 3263 |
| Chain | Residue |
| C | LYS77 |
| C | ARG80 |
| C | TYR81 |
| C | ILE84 |
| C | VAL91 |
| C | THR95 |
| C | PHE98 |
| C | PHE244 |
| C | VAL247 |
| C | HOH3619 |
| T | SER2 |
| T | ALA3 |
| T | LYS5 |
| T | GLY6 |
| T | HIS8 |
| site_id | FC5 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE CDL T 4269 |
| Chain | Residue |
| A | PHE282 |
| A | ILE286 |
| A | ASP300 |
| A | TYR304 |
| A | SER307 |
| B | ALA77 |
| B | LEU78 |
| B | LEU81 |
| B | TYR85 |
| B | HOH4144 |
| P | LEU127 |
| P | LEU131 |
| P | SER135 |
| P | LEU138 |
| P | VAL142 |
| P | LEU250 |
| P | TYR253 |
| P | VAL254 |
| P | TRP258 |
| P | PEK4265 |
| T | SER27 |
| T | LEU30 |
| T | CYS31 |
| T | ASN34 |
| T | LEU37 |
| T | HIS38 |
| T | HOH2346 |
| T | HOH2415 |
| T | HOH2542 |
| site_id | FC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CHD W 4060 |
| Chain | Residue |
| N | ILE3 |
| N | LEU7 |
| W | TYR32 |
| W | ARG33 |
| W | MET36 |
| W | LEU40 |
| W | HOH2229 |
| site_id | FC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE DMU Z 4526 |
| Chain | Residue |
| Q | LEU95 |
| Q | TRP98 |
| Z | LEU27 |
| Z | LEU28 |
| Z | GLY31 |
| Z | TRP32 |
| Z | TYR35 |
| Z | HIS36 |
Functional Information from PROSITE/UniProt
| site_id | PS00077 |
| Number of Residues | 56 |
| Details | COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyililpgfgmishivtyysgkkepfgymgmvwammsigflgfivwa.HH |
| Chain | Residue | Details |
| A | TRP236-HIS291 |
| site_id | PS00078 |
| Number of Residues | 49 |
| Details | COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. VlHswavpslglktdaipgrlnqttlmssrpglyygq......CseiCgsnHsfM |
| Chain | Residue | Details |
| B | VAL159-MET207 |
| site_id | PS00848 |
| Number of Residues | 23 |
| Details | COX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. VIWfwlhkgeaqrCpsCGthYKL |
| Chain | Residue | Details |
| F | VAL69-LEU91 |
| site_id | PS01329 |
| Number of Residues | 18 |
| Details | COX6A Cytochrome c oxidase subunit VIa signature. IRtKpFsWGDGnHTfFhN |
| Chain | Residue | Details |
| G | ILE55-ASN72 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | TOPO_DOM: Mitochondrial matrix => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| M | ILE1-SER11 | |
| N | SER262-GLY269 | |
| N | SER401-ASN406 | |
| N | LYS479-LYS514 | |
| Z | ILE1-SER11 | |
| F | CYS82 | |
| F | CYS85 | |
| S | CYS60 | |
| S | CYS62 | |
| S | CYS82 | |
| S | CYS85 | |
| N | MET171-PRO182 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 46 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| M | PRO12-TYR35 | |
| Z | PRO12-TYR35 | |
| F | LYS90 | |
| S | LYS37 | |
| S | LYS55 | |
| S | LYS90 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | TOPO_DOM: Mitochondrial intermembrane => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| M | HIS36-ALA46 | |
| Z | HIS36-ALA46 | |
| C | ALA184-ASP190 | |
| C | TYR257-SER261 | |
| P | PHE35-MET40 | |
| P | LEU106-GLU128 | |
| P | ALA184-ASP190 | |
| P | TYR257-SER261 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P17665 |
| Chain | Residue | Details |
| L | LYS9 | |
| Y | LYS9 | |
| Q | LYS7 | |
| Q | LYS38 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P13073 |
| Chain | Residue | Details |
| D | LYS31 | |
| O | CYS200 | |
| O | HIS204 | |
| O | MET207 | |
| Q | LYS31 | |
| B | GLU198 | |
| B | CYS200 | |
| B | HIS204 | |
| B | MET207 | |
| O | HIS161 | |
| O | CYS196 | |
| O | GLU198 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P10888 |
| Chain | Residue | Details |
| D | SER34 | |
| D | SER36 | |
| Q | SER34 | |
| Q | SER36 | |
| N | ARG213-ASP227 | |
| N | VAL287-ASP298 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P19783 |
| Chain | Residue | Details |
| D | LYS45 | |
| Q | LYS45 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 64 |
| Details | TRANSMEM: Helical; Name=VI => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| C | GLY191-LEU223 | |
| P | GLY191-LEU223 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 46 |
| Details | TRANSMEM: Helical; Name=VII => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| C | PHE233-ILE256 | |
| P | PHE233-ILE256 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 32 |
| Details | TRANSMEM: Helical; Name=VII => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| A | TYR270-ILE286 | |
| N | TYR270-ILE286 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 56 |
| Details | TRANSMEM: Helical; Name=VIII => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| A | VAL299-LEU327 | |
| N | VAL299-LEU327 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 14 |
| Details | TOPO_DOM: Mitochondrial matrix => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| A | HIS328-SER335 | |
| N | HIS328-SER335 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=IX => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| A | PRO336-VAL357 | |
| N | PRO336-VAL357 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 48 |
| Details | TOPO_DOM: Mitochondrial intermembrane => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| A | LEU358-THR370 | |
| A | SER434-ALA446 | |
| N | LEU358-THR370 | |
| N | SER434-ALA446 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 58 |
| Details | TRANSMEM: Helical; Name=X => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| A | TYR371-PHE400 | |
| N | TYR371-PHE400 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 52 |
| Details | TRANSMEM: Helical; Name=XI => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| A | ASP407-LEU433 | |
| N | ASP407-LEU433 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 62 |
| Details | TRANSMEM: Helical; Name=XII => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| A | TYR447-SER478 | |
| N | TYR447-SER478 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27605664, ECO:0000305|PubMed:23537388 |
| Chain | Residue | Details |
| A | GLU40 | |
| A | GLY45 | |
| A | SER441 | |
| N | GLU40 | |
| N | GLY45 | |
| N | SER441 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 6 |
| Details | BINDING: axial binding residue => ECO:0000269|PubMed:20385840, ECO:0000269|PubMed:8638158 |
| Chain | Residue | Details |
| A | HIS61 | |
| A | HIS376 | |
| A | HIS378 | |
| N | HIS61 | |
| N | HIS376 | |
| N | HIS378 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20385840, ECO:0000269|PubMed:8638158 |
| Chain | Residue | Details |
| A | HIS240 | |
| N | ASP369 | |
| A | HIS290 | |
| A | HIS291 | |
| A | HIS368 | |
| A | ASP369 | |
| N | HIS240 | |
| N | HIS290 | |
| N | HIS291 | |
| N | HIS368 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305 |
| Chain | Residue | Details |
| A | TYR244 | |
| N | TYR244 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 2 |
| Details | MOD_RES: N-formylmethionine => ECO:0000269|PubMed:2165784 |
| Chain | Residue | Details |
| A | FME1 | |
| N | FME1 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 4 |
| Details | CROSSLNK: 1'-histidyl-3'-tyrosine (His-Tyr) => ECO:0000269|PubMed:10338009 |
| Chain | Residue | Details |
| A | HIS240 | |
| A | TYR244 | |
| N | HIS240 | |
| N | TYR244 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 7 |
| Details | Annotated By Reference To The Literature 1ar1 |
| Chain | Residue | Details |
| N | ARG438 | |
| N | PHE377 | |
| N | ARG439 | |
| N | HIS376 | |
| N | HIS240 | |
| N | TYR244 | |
| N | HIS378 |
| site_id | CSA2 |
| Number of Residues | 7 |
| Details | Annotated By Reference To The Literature 1ar1 |
| Chain | Residue | Details |
| A | ARG438 | |
| A | PHE377 | |
| A | ARG439 | |
| A | HIS376 | |
| A | HIS240 | |
| A | TYR244 | |
| A | HIS378 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ar1 |
| Chain | Residue | Details |
| A | GLU242 | |
| A | LYS319 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ar1 |
| Chain | Residue | Details |
| N | GLU242 | |
| N | LYS319 |
| site_id | MCSA1 |
| Number of Residues | 14 |
| Details | M-CSA 124 |
| Chain | Residue | Details |
| A | HIS61 | metal ligand |
| A | HIS290 | metal ligand |
| A | HIS291 | metal ligand, proton acceptor, proton donor |
| A | THR316 | proton acceptor, proton donor, proton relay |
| A | LYS319 | proton acceptor, proton donor, proton relay |
| A | ARG438 | proton acceptor, proton donor, proton relay |
| A | ASP91 | proton acceptor, proton donor, proton relay |
| A | TRP126 | proton acceptor, proton donor, proton relay |
| A | SER156 | proton acceptor, proton donor, proton relay |
| A | SER157 | proton acceptor, proton donor, proton relay |
| A | HIS240 | covalently attached, electrostatic stabiliser, metal ligand, radical stabiliser |
| A | GLU242 | proton acceptor, proton donor, proton relay |
| A | TYR244 | covalently attached, hydrogen radical donor, proton acceptor, proton donor, proton relay, single electron acceptor |
| A | SER255 | proton acceptor, proton donor, proton relay |
| site_id | MCSA2 |
| Number of Residues | 14 |
| Details | M-CSA 124 |
| Chain | Residue | Details |
| N | HIS61 | metal ligand |
| N | HIS290 | metal ligand |
| N | HIS291 | metal ligand, proton acceptor, proton donor |
| N | THR316 | proton acceptor, proton donor, proton relay |
| N | LYS319 | proton acceptor, proton donor, proton relay |
| N | ARG438 | proton acceptor, proton donor, proton relay |
| N | ASP91 | proton acceptor, proton donor, proton relay |
| N | TRP126 | proton acceptor, proton donor, proton relay |
| N | SER156 | proton acceptor, proton donor, proton relay |
| N | SER157 | proton acceptor, proton donor, proton relay |
| N | HIS240 | covalently attached, electrostatic stabiliser, metal ligand, radical stabiliser |
| N | GLU242 | proton acceptor, proton donor, proton relay |
| N | TYR244 | covalently attached, hydrogen radical donor, proton acceptor, proton donor, proton relay, single electron acceptor |
| N | SER255 | proton acceptor, proton donor, proton relay |
