1V0F
Endosialidase of Bacteriophage K1F in complex with oligomeric alpha-2,8-sialic acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016996 | molecular_function | endo-alpha-(2,8)-sialidase activity |
| B | 0016996 | molecular_function | endo-alpha-(2,8)-sialidase activity |
| C | 0016996 | molecular_function | endo-alpha-(2,8)-sialidase activity |
| D | 0016996 | molecular_function | endo-alpha-(2,8)-sialidase activity |
| E | 0016996 | molecular_function | endo-alpha-(2,8)-sialidase activity |
| F | 0016996 | molecular_function | endo-alpha-(2,8)-sialidase activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 66 |
| Details | Repeat: {"description":"BNR 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"BNR 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 66 |
| Details | Repeat: {"description":"BNR 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"15608653","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20096705","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"15608653","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 36 |
| Details | Site: {"description":"Binding to sialic acid","evidences":[{"source":"PubMed","id":"20096705","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1v0e |
| Chain | Residue | Details |
| A | GLU581 | |
| A | ARG596 | |
| A | ARG647 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1v0e |
| Chain | Residue | Details |
| B | GLU581 | |
| B | ARG596 | |
| B | ARG647 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1v0e |
| Chain | Residue | Details |
| C | GLU581 | |
| C | ARG596 | |
| C | ARG647 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1v0e |
| Chain | Residue | Details |
| D | GLU581 | |
| D | ARG596 | |
| D | ARG647 |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1v0e |
| Chain | Residue | Details |
| E | GLU581 | |
| E | ARG596 | |
| E | ARG647 |
| site_id | CSA6 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1v0e |
| Chain | Residue | Details |
| F | GLU581 | |
| F | ARG596 | |
| F | ARG647 |
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 829 |
| Chain | Residue | Details |
| A | TYR325 | promote heterolysis, proton acceptor, proton donor |
| A | HIS350 | promote heterolysis, proton acceptor, proton donor, proton relay |
| A | GLU581 | activator, electrostatic stabiliser, increase nucleophilicity, promote heterolysis, proton acceptor, proton donor |
| A | ARG596 | electrostatic stabiliser, increase acidity |
| A | ARG647 | electrostatic stabiliser, increase acidity |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 829 |
| Chain | Residue | Details |
| B | TYR325 | promote heterolysis, proton acceptor, proton donor |
| B | HIS350 | promote heterolysis, proton acceptor, proton donor, proton relay |
| B | GLU581 | activator, electrostatic stabiliser, increase nucleophilicity, promote heterolysis, proton acceptor, proton donor |
| B | ARG596 | electrostatic stabiliser, increase acidity |
| B | ARG647 | electrostatic stabiliser, increase acidity |
| site_id | MCSA3 |
| Number of Residues | 5 |
| Details | M-CSA 829 |
| Chain | Residue | Details |
| C | TYR325 | promote heterolysis, proton acceptor, proton donor |
| C | HIS350 | promote heterolysis, proton acceptor, proton donor, proton relay |
| C | GLU581 | activator, electrostatic stabiliser, increase nucleophilicity, promote heterolysis, proton acceptor, proton donor |
| C | ARG596 | electrostatic stabiliser, increase acidity |
| C | ARG647 | electrostatic stabiliser, increase acidity |
| site_id | MCSA4 |
| Number of Residues | 5 |
| Details | M-CSA 829 |
| Chain | Residue | Details |
| D | TYR325 | promote heterolysis, proton acceptor, proton donor |
| D | HIS350 | promote heterolysis, proton acceptor, proton donor, proton relay |
| D | GLU581 | activator, electrostatic stabiliser, increase nucleophilicity, promote heterolysis, proton acceptor, proton donor |
| D | ARG596 | electrostatic stabiliser, increase acidity |
| D | ARG647 | electrostatic stabiliser, increase acidity |
| site_id | MCSA5 |
| Number of Residues | 5 |
| Details | M-CSA 829 |
| Chain | Residue | Details |
| E | TYR325 | promote heterolysis, proton acceptor, proton donor |
| E | HIS350 | promote heterolysis, proton acceptor, proton donor, proton relay |
| E | GLU581 | activator, electrostatic stabiliser, increase nucleophilicity, promote heterolysis, proton acceptor, proton donor |
| E | ARG596 | electrostatic stabiliser, increase acidity |
| E | ARG647 | electrostatic stabiliser, increase acidity |
| site_id | MCSA6 |
| Number of Residues | 5 |
| Details | M-CSA 829 |
| Chain | Residue | Details |
| F | TYR325 | promote heterolysis, proton acceptor, proton donor |
| F | HIS350 | promote heterolysis, proton acceptor, proton donor, proton relay |
| F | GLU581 | activator, electrostatic stabiliser, increase nucleophilicity, promote heterolysis, proton acceptor, proton donor |
| F | ARG596 | electrostatic stabiliser, increase acidity |
| F | ARG647 | electrostatic stabiliser, increase acidity |
