1UZN
MabA from Mycobacterium tuberculosis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0018454 | molecular_function | acetoacetyl-CoA reductase activity |
| A | 0032787 | biological_process | monocarboxylic acid metabolic process |
| A | 0046459 | biological_process | short-chain fatty acid metabolic process |
| A | 0070402 | molecular_function | NADPH binding |
| A | 0071768 | biological_process | mycolic acid biosynthetic process |
| B | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0018454 | molecular_function | acetoacetyl-CoA reductase activity |
| B | 0032787 | biological_process | monocarboxylic acid metabolic process |
| B | 0046459 | biological_process | short-chain fatty acid metabolic process |
| B | 0070402 | molecular_function | NADPH binding |
| B | 0071768 | biological_process | mycolic acid biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CS A1248 |
| Chain | Residue |
| A | ALA36 |
| A | HIS40 |
| A | HOH2018 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CS A1250 |
| Chain | Residue |
| A | PHE13 |
| A | ALA37 |
| A | ASP38 |
| A | HOH2014 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CS B1248 |
| Chain | Residue |
| B | HOH2014 |
| B | ALA36 |
| B | HIS40 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CS B1250 |
| Chain | Residue |
| B | ALA37 |
| B | ASP38 |
| B | HOH2021 |
| B | HOH2022 |
| site_id | AC5 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE NAP A1249 |
| Chain | Residue |
| A | GLY22 |
| A | ASN24 |
| A | ARG25 |
| A | GLY26 |
| A | ILE27 |
| A | ARG47 |
| A | VAL60 |
| A | ASP61 |
| A | VAL62 |
| A | ALA89 |
| A | GLY90 |
| A | LEU91 |
| A | ALA111 |
| A | THR188 |
| A | HOH2023 |
| A | HOH2058 |
| A | HOH2138 |
| A | HOH2139 |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvsglwgignQanYAASKAGViGMArSIA |
| Chain | Residue | Details |
| A | SER140-ALA168 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10001","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15977159","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1UZN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P71534","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Site: {"description":"Important for activity","evidences":[{"source":"PubMed","id":"23006410","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 5 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20178986","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| A | SER140 | |
| A | LYS157 | |
| A | TYR153 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| B | SER140 | |
| B | LYS157 | |
| B | TYR153 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| A | SER140 | |
| A | ASN112 | |
| A | LYS157 | |
| A | TYR153 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| B | SER140 | |
| B | ASN112 | |
| B | LYS157 | |
| B | TYR153 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| A | GLN150 | |
| A | LYS157 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| B | GLN150 | |
| B | LYS157 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| A | LYS157 | |
| A | TYR153 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| B | LYS157 | |
| B | TYR153 |
