1UZ4

Common inhibition of beta-glucosidase and beta-mannosidase by isofagomine lactam reflects different conformational intineraries for glucoside and mannoside hydrolysis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000272	biological_process	polysaccharide catabolic process
A	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016985	molecular_function	mannan endo-1,4-beta-mannosidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SO4 A1436

Chain	Residue
A	ALA65
A	HOH2526
A	HOH2527
A	TYR115
A	GLU119
A	LYS122
A	ARG123
A	THR224
A	ALA225
A	HOH2076
A	HOH2525

---

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE IFL A1432

Chain	Residue
A	TRP137
A	ASN214
A	GLU215
A	TRP285
A	ASN288
A	GLU330
A	TRP376
A	PRO401
A	GLN403
A	GLU404
A	TYR409
A	GOL1433
A	GOL1434

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A1433

Chain	Residue
A	TRP135
A	GLN403
A	GLU404
A	IFL1432
A	GOL1434
A	HOH2206
A	HOH2521

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A1434

Chain	Residue
A	TRP135
A	GLU215
A	GLU256
A	TRP285
A	ASN288
A	TRP289
A	IFL1432
A	GOL1433
A	HOH2522

---

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A1435

Chain	Residue
A	LEU52
A	GLU57
A	VAL58
A	ARG63
A	ASP396
A	PHE397
A	HOH2050
A	HOH2476
A	HOH2523
A	HOH2524

---