Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1UXM

A4V mutant of human SOD1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000302	biological_process	response to reactive oxygen species
A	0000303	biological_process	response to superoxide
A	0001541	biological_process	ovarian follicle development
A	0001819	biological_process	positive regulation of cytokine production
A	0001890	biological_process	placenta development
A	0001895	biological_process	retina homeostasis
A	0001975	biological_process	response to amphetamine
A	0002262	biological_process	myeloid cell homeostasis
A	0004784	molecular_function	superoxide dismutase activity
A	0005507	molecular_function	copper ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005758	cellular_component	mitochondrial intermembrane space
A	0005759	cellular_component	mitochondrial matrix
A	0005764	cellular_component	lysosome
A	0005777	cellular_component	peroxisome
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006749	biological_process	glutathione metabolic process
A	0006801	biological_process	superoxide metabolic process
A	0006879	biological_process	intracellular iron ion homeostasis
A	0006915	biological_process	apoptotic process
A	0006979	biological_process	response to oxidative stress
A	0007283	biological_process	spermatogenesis
A	0007566	biological_process	embryo implantation
A	0007605	biological_process	sensory perception of sound
A	0007626	biological_process	locomotory behavior
A	0008089	biological_process	anterograde axonal transport
A	0008090	biological_process	retrograde axonal transport
A	0008217	biological_process	regulation of blood pressure
A	0008270	molecular_function	zinc ion binding
A	0008340	biological_process	determination of adult lifespan
A	0009408	biological_process	response to heat
A	0009410	biological_process	response to xenobiotic stimulus
A	0010467	biological_process	gene expression
A	0016209	molecular_function	antioxidant activity
A	0016491	molecular_function	oxidoreductase activity
A	0019226	biological_process	transmission of nerve impulse
A	0019228	biological_process	neuronal action potential
A	0019430	biological_process	removal of superoxide radicals
A	0019899	molecular_function	enzyme binding
A	0030141	cellular_component	secretory granule
A	0030346	molecular_function	protein phosphatase 2B binding
A	0031045	cellular_component	dense core granule
A	0031267	molecular_function	small GTPase binding
A	0031410	cellular_component	cytoplasmic vesicle
A	0031667	biological_process	response to nutrient levels
A	0032287	biological_process	peripheral nervous system myelin maintenance
A	0032839	cellular_component	dendrite cytoplasm
A	0032930	biological_process	positive regulation of superoxide anion generation
A	0032991	cellular_component	protein-containing complex
A	0033081	biological_process	regulation of T cell differentiation in thymus
A	0034465	biological_process	response to carbon monoxide
A	0034599	biological_process	cellular response to oxidative stress
A	0035234	biological_process	ectopic germ cell programmed cell death
A	0035865	biological_process	cellular response to potassium ion
A	0040014	biological_process	regulation of multicellular organism growth
A	0042542	biological_process	response to hydrogen peroxide
A	0042554	biological_process	superoxide anion generation
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0043025	cellular_component	neuronal cell body
A	0043065	biological_process	positive regulation of apoptotic process
A	0043066	biological_process	negative regulation of apoptotic process
A	0043087	biological_process	regulation of GTPase activity
A	0043410	biological_process	positive regulation of MAPK cascade
A	0043524	biological_process	negative regulation of neuron apoptotic process
A	0045471	biological_process	response to ethanol
A	0046620	biological_process	regulation of organ growth
A	0046688	biological_process	response to copper ion
A	0046716	biological_process	muscle cell cellular homeostasis
A	0046872	molecular_function	metal ion binding
A	0048538	biological_process	thymus development
A	0048678	biological_process	response to axon injury
A	0050665	biological_process	hydrogen peroxide biosynthetic process
A	0050728	biological_process	negative regulation of inflammatory response
A	0050766	biological_process	positive regulation of phagocytosis
A	0051087	molecular_function	protein-folding chaperone binding
A	0051093	biological_process	negative regulation of developmental process
A	0051881	biological_process	regulation of mitochondrial membrane potential
A	0060047	biological_process	heart contraction
A	0060052	biological_process	neurofilament cytoskeleton organization
A	0060087	biological_process	relaxation of vascular associated smooth muscle
A	0060088	biological_process	auditory receptor cell stereocilium organization
A	0070062	cellular_component	extracellular exosome
A	0071276	biological_process	cellular response to cadmium ion
A	0071318	biological_process	cellular response to ATP
A	0072593	biological_process	reactive oxygen species metabolic process
A	0097332	biological_process	response to antipsychotic drug
A	0099610	biological_process	action potential initiation
A	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
A	1904115	cellular_component	axon cytoplasm
A	2000242	biological_process	negative regulation of reproductive process
B	0000302	biological_process	response to reactive oxygen species
B	0000303	biological_process	response to superoxide
B	0001541	biological_process	ovarian follicle development
B	0001819	biological_process	positive regulation of cytokine production
B	0001890	biological_process	placenta development
B	0001895	biological_process	retina homeostasis
B	0001975	biological_process	response to amphetamine
B	0002262	biological_process	myeloid cell homeostasis
B	0004784	molecular_function	superoxide dismutase activity
B	0005507	molecular_function	copper ion binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005758	cellular_component	mitochondrial intermembrane space
B	0005759	cellular_component	mitochondrial matrix
B	0005764	cellular_component	lysosome
B	0005777	cellular_component	peroxisome
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006749	biological_process	glutathione metabolic process
B	0006801	biological_process	superoxide metabolic process
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006915	biological_process	apoptotic process
B	0006979	biological_process	response to oxidative stress
B	0007283	biological_process	spermatogenesis
B	0007566	biological_process	embryo implantation
B	0007605	biological_process	sensory perception of sound
B	0007626	biological_process	locomotory behavior
B	0008089	biological_process	anterograde axonal transport
B	0008090	biological_process	retrograde axonal transport
B	0008217	biological_process	regulation of blood pressure
B	0008270	molecular_function	zinc ion binding
B	0008340	biological_process	determination of adult lifespan
B	0009408	biological_process	response to heat
B	0009410	biological_process	response to xenobiotic stimulus
B	0010467	biological_process	gene expression
B	0016209	molecular_function	antioxidant activity
B	0016491	molecular_function	oxidoreductase activity
B	0019226	biological_process	transmission of nerve impulse
B	0019228	biological_process	neuronal action potential
B	0019430	biological_process	removal of superoxide radicals
B	0019899	molecular_function	enzyme binding
B	0030141	cellular_component	secretory granule
B	0030346	molecular_function	protein phosphatase 2B binding
B	0031045	cellular_component	dense core granule
B	0031267	molecular_function	small GTPase binding
B	0031410	cellular_component	cytoplasmic vesicle
B	0031667	biological_process	response to nutrient levels
B	0032287	biological_process	peripheral nervous system myelin maintenance
B	0032839	cellular_component	dendrite cytoplasm
B	0032930	biological_process	positive regulation of superoxide anion generation
B	0032991	cellular_component	protein-containing complex
B	0033081	biological_process	regulation of T cell differentiation in thymus
B	0034465	biological_process	response to carbon monoxide
B	0034599	biological_process	cellular response to oxidative stress
B	0035234	biological_process	ectopic germ cell programmed cell death
B	0035865	biological_process	cellular response to potassium ion
B	0040014	biological_process	regulation of multicellular organism growth
B	0042542	biological_process	response to hydrogen peroxide
B	0042554	biological_process	superoxide anion generation
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0043025	cellular_component	neuronal cell body
B	0043065	biological_process	positive regulation of apoptotic process
B	0043066	biological_process	negative regulation of apoptotic process
B	0043087	biological_process	regulation of GTPase activity
B	0043410	biological_process	positive regulation of MAPK cascade
B	0043524	biological_process	negative regulation of neuron apoptotic process
B	0045471	biological_process	response to ethanol
B	0046620	biological_process	regulation of organ growth
B	0046688	biological_process	response to copper ion
B	0046716	biological_process	muscle cell cellular homeostasis
B	0046872	molecular_function	metal ion binding
B	0048538	biological_process	thymus development
B	0048678	biological_process	response to axon injury
B	0050665	biological_process	hydrogen peroxide biosynthetic process
B	0050728	biological_process	negative regulation of inflammatory response
B	0050766	biological_process	positive regulation of phagocytosis
B	0051087	molecular_function	protein-folding chaperone binding
B	0051093	biological_process	negative regulation of developmental process
B	0051881	biological_process	regulation of mitochondrial membrane potential
B	0060047	biological_process	heart contraction
B	0060052	biological_process	neurofilament cytoskeleton organization
B	0060087	biological_process	relaxation of vascular associated smooth muscle
B	0060088	biological_process	auditory receptor cell stereocilium organization
B	0070062	cellular_component	extracellular exosome
B	0071276	biological_process	cellular response to cadmium ion
B	0071318	biological_process	cellular response to ATP
B	0072593	biological_process	reactive oxygen species metabolic process
B	0097332	biological_process	response to antipsychotic drug
B	0099610	biological_process	action potential initiation
B	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
B	1904115	cellular_component	axon cytoplasm
B	2000242	biological_process	negative regulation of reproductive process
C	0000302	biological_process	response to reactive oxygen species
C	0000303	biological_process	response to superoxide
C	0001541	biological_process	ovarian follicle development
C	0001819	biological_process	positive regulation of cytokine production
C	0001890	biological_process	placenta development
C	0001895	biological_process	retina homeostasis
C	0001975	biological_process	response to amphetamine
C	0002262	biological_process	myeloid cell homeostasis
C	0004784	molecular_function	superoxide dismutase activity
C	0005507	molecular_function	copper ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005758	cellular_component	mitochondrial intermembrane space
C	0005759	cellular_component	mitochondrial matrix
C	0005764	cellular_component	lysosome
C	0005777	cellular_component	peroxisome
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006749	biological_process	glutathione metabolic process
C	0006801	biological_process	superoxide metabolic process
C	0006879	biological_process	intracellular iron ion homeostasis
C	0006915	biological_process	apoptotic process
C	0006979	biological_process	response to oxidative stress
C	0007283	biological_process	spermatogenesis
C	0007566	biological_process	embryo implantation
C	0007605	biological_process	sensory perception of sound
C	0007626	biological_process	locomotory behavior
C	0008089	biological_process	anterograde axonal transport
C	0008090	biological_process	retrograde axonal transport
C	0008217	biological_process	regulation of blood pressure
C	0008270	molecular_function	zinc ion binding
C	0008340	biological_process	determination of adult lifespan
C	0009408	biological_process	response to heat
C	0009410	biological_process	response to xenobiotic stimulus
C	0010467	biological_process	gene expression
C	0016209	molecular_function	antioxidant activity
C	0016491	molecular_function	oxidoreductase activity
C	0019226	biological_process	transmission of nerve impulse
C	0019228	biological_process	neuronal action potential
C	0019430	biological_process	removal of superoxide radicals
C	0019899	molecular_function	enzyme binding
C	0030141	cellular_component	secretory granule
C	0030346	molecular_function	protein phosphatase 2B binding
C	0031045	cellular_component	dense core granule
C	0031267	molecular_function	small GTPase binding
C	0031410	cellular_component	cytoplasmic vesicle
C	0031667	biological_process	response to nutrient levels
C	0032287	biological_process	peripheral nervous system myelin maintenance
C	0032839	cellular_component	dendrite cytoplasm
C	0032930	biological_process	positive regulation of superoxide anion generation
C	0032991	cellular_component	protein-containing complex
C	0033081	biological_process	regulation of T cell differentiation in thymus
C	0034465	biological_process	response to carbon monoxide
C	0034599	biological_process	cellular response to oxidative stress
C	0035234	biological_process	ectopic germ cell programmed cell death
C	0035865	biological_process	cellular response to potassium ion
C	0040014	biological_process	regulation of multicellular organism growth
C	0042542	biological_process	response to hydrogen peroxide
C	0042554	biological_process	superoxide anion generation
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0043025	cellular_component	neuronal cell body
C	0043065	biological_process	positive regulation of apoptotic process
C	0043066	biological_process	negative regulation of apoptotic process
C	0043087	biological_process	regulation of GTPase activity
C	0043410	biological_process	positive regulation of MAPK cascade
C	0043524	biological_process	negative regulation of neuron apoptotic process
C	0045471	biological_process	response to ethanol
C	0046620	biological_process	regulation of organ growth
C	0046688	biological_process	response to copper ion
C	0046716	biological_process	muscle cell cellular homeostasis
C	0046872	molecular_function	metal ion binding
C	0048538	biological_process	thymus development
C	0048678	biological_process	response to axon injury
C	0050665	biological_process	hydrogen peroxide biosynthetic process
C	0050728	biological_process	negative regulation of inflammatory response
C	0050766	biological_process	positive regulation of phagocytosis
C	0051087	molecular_function	protein-folding chaperone binding
C	0051093	biological_process	negative regulation of developmental process
C	0051881	biological_process	regulation of mitochondrial membrane potential
C	0060047	biological_process	heart contraction
C	0060052	biological_process	neurofilament cytoskeleton organization
C	0060087	biological_process	relaxation of vascular associated smooth muscle
C	0060088	biological_process	auditory receptor cell stereocilium organization
C	0070062	cellular_component	extracellular exosome
C	0071276	biological_process	cellular response to cadmium ion
C	0071318	biological_process	cellular response to ATP
C	0072593	biological_process	reactive oxygen species metabolic process
C	0097332	biological_process	response to antipsychotic drug
C	0099610	biological_process	action potential initiation
C	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
C	1904115	cellular_component	axon cytoplasm
C	2000242	biological_process	negative regulation of reproductive process
D	0000302	biological_process	response to reactive oxygen species
D	0000303	biological_process	response to superoxide
D	0001541	biological_process	ovarian follicle development
D	0001819	biological_process	positive regulation of cytokine production
D	0001890	biological_process	placenta development
D	0001895	biological_process	retina homeostasis
D	0001975	biological_process	response to amphetamine
D	0002262	biological_process	myeloid cell homeostasis
D	0004784	molecular_function	superoxide dismutase activity
D	0005507	molecular_function	copper ion binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005758	cellular_component	mitochondrial intermembrane space
D	0005759	cellular_component	mitochondrial matrix
D	0005764	cellular_component	lysosome
D	0005777	cellular_component	peroxisome
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006749	biological_process	glutathione metabolic process
D	0006801	biological_process	superoxide metabolic process
D	0006879	biological_process	intracellular iron ion homeostasis
D	0006915	biological_process	apoptotic process
D	0006979	biological_process	response to oxidative stress
D	0007283	biological_process	spermatogenesis
D	0007566	biological_process	embryo implantation
D	0007605	biological_process	sensory perception of sound
D	0007626	biological_process	locomotory behavior
D	0008089	biological_process	anterograde axonal transport
D	0008090	biological_process	retrograde axonal transport
D	0008217	biological_process	regulation of blood pressure
D	0008270	molecular_function	zinc ion binding
D	0008340	biological_process	determination of adult lifespan
D	0009408	biological_process	response to heat
D	0009410	biological_process	response to xenobiotic stimulus
D	0010467	biological_process	gene expression
D	0016209	molecular_function	antioxidant activity
D	0016491	molecular_function	oxidoreductase activity
D	0019226	biological_process	transmission of nerve impulse
D	0019228	biological_process	neuronal action potential
D	0019430	biological_process	removal of superoxide radicals
D	0019899	molecular_function	enzyme binding
D	0030141	cellular_component	secretory granule
D	0030346	molecular_function	protein phosphatase 2B binding
D	0031045	cellular_component	dense core granule
D	0031267	molecular_function	small GTPase binding
D	0031410	cellular_component	cytoplasmic vesicle
D	0031667	biological_process	response to nutrient levels
D	0032287	biological_process	peripheral nervous system myelin maintenance
D	0032839	cellular_component	dendrite cytoplasm
D	0032930	biological_process	positive regulation of superoxide anion generation
D	0032991	cellular_component	protein-containing complex
D	0033081	biological_process	regulation of T cell differentiation in thymus
D	0034465	biological_process	response to carbon monoxide
D	0034599	biological_process	cellular response to oxidative stress
D	0035234	biological_process	ectopic germ cell programmed cell death
D	0035865	biological_process	cellular response to potassium ion
D	0040014	biological_process	regulation of multicellular organism growth
D	0042542	biological_process	response to hydrogen peroxide
D	0042554	biological_process	superoxide anion generation
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0043025	cellular_component	neuronal cell body
D	0043065	biological_process	positive regulation of apoptotic process
D	0043066	biological_process	negative regulation of apoptotic process
D	0043087	biological_process	regulation of GTPase activity
D	0043410	biological_process	positive regulation of MAPK cascade
D	0043524	biological_process	negative regulation of neuron apoptotic process
D	0045471	biological_process	response to ethanol
D	0046620	biological_process	regulation of organ growth
D	0046688	biological_process	response to copper ion
D	0046716	biological_process	muscle cell cellular homeostasis
D	0046872	molecular_function	metal ion binding
D	0048538	biological_process	thymus development
D	0048678	biological_process	response to axon injury
D	0050665	biological_process	hydrogen peroxide biosynthetic process
D	0050728	biological_process	negative regulation of inflammatory response
D	0050766	biological_process	positive regulation of phagocytosis
D	0051087	molecular_function	protein-folding chaperone binding
D	0051093	biological_process	negative regulation of developmental process
D	0051881	biological_process	regulation of mitochondrial membrane potential
D	0060047	biological_process	heart contraction
D	0060052	biological_process	neurofilament cytoskeleton organization
D	0060087	biological_process	relaxation of vascular associated smooth muscle
D	0060088	biological_process	auditory receptor cell stereocilium organization
D	0070062	cellular_component	extracellular exosome
D	0071276	biological_process	cellular response to cadmium ion
D	0071318	biological_process	cellular response to ATP
D	0072593	biological_process	reactive oxygen species metabolic process
D	0097332	biological_process	response to antipsychotic drug
D	0099610	biological_process	action potential initiation
D	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
D	1904115	cellular_component	axon cytoplasm
D	2000242	biological_process	negative regulation of reproductive process
E	0000302	biological_process	response to reactive oxygen species
E	0000303	biological_process	response to superoxide
E	0001541	biological_process	ovarian follicle development
E	0001819	biological_process	positive regulation of cytokine production
E	0001890	biological_process	placenta development
E	0001895	biological_process	retina homeostasis
E	0001975	biological_process	response to amphetamine
E	0002262	biological_process	myeloid cell homeostasis
E	0004784	molecular_function	superoxide dismutase activity
E	0005507	molecular_function	copper ion binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005758	cellular_component	mitochondrial intermembrane space
E	0005759	cellular_component	mitochondrial matrix
E	0005764	cellular_component	lysosome
E	0005777	cellular_component	peroxisome
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006749	biological_process	glutathione metabolic process
E	0006801	biological_process	superoxide metabolic process
E	0006879	biological_process	intracellular iron ion homeostasis
E	0006915	biological_process	apoptotic process
E	0006979	biological_process	response to oxidative stress
E	0007283	biological_process	spermatogenesis
E	0007566	biological_process	embryo implantation
E	0007605	biological_process	sensory perception of sound
E	0007626	biological_process	locomotory behavior
E	0008089	biological_process	anterograde axonal transport
E	0008090	biological_process	retrograde axonal transport
E	0008217	biological_process	regulation of blood pressure
E	0008270	molecular_function	zinc ion binding
E	0008340	biological_process	determination of adult lifespan
E	0009408	biological_process	response to heat
E	0009410	biological_process	response to xenobiotic stimulus
E	0010467	biological_process	gene expression
E	0016209	molecular_function	antioxidant activity
E	0016491	molecular_function	oxidoreductase activity
E	0019226	biological_process	transmission of nerve impulse
E	0019228	biological_process	neuronal action potential
E	0019430	biological_process	removal of superoxide radicals
E	0019899	molecular_function	enzyme binding
E	0030141	cellular_component	secretory granule
E	0030346	molecular_function	protein phosphatase 2B binding
E	0031045	cellular_component	dense core granule
E	0031267	molecular_function	small GTPase binding
E	0031410	cellular_component	cytoplasmic vesicle
E	0031667	biological_process	response to nutrient levels
E	0032287	biological_process	peripheral nervous system myelin maintenance
E	0032839	cellular_component	dendrite cytoplasm
E	0032930	biological_process	positive regulation of superoxide anion generation
E	0032991	cellular_component	protein-containing complex
E	0033081	biological_process	regulation of T cell differentiation in thymus
E	0034465	biological_process	response to carbon monoxide
E	0034599	biological_process	cellular response to oxidative stress
E	0035234	biological_process	ectopic germ cell programmed cell death
E	0035865	biological_process	cellular response to potassium ion
E	0040014	biological_process	regulation of multicellular organism growth
E	0042542	biological_process	response to hydrogen peroxide
E	0042554	biological_process	superoxide anion generation
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0043025	cellular_component	neuronal cell body
E	0043065	biological_process	positive regulation of apoptotic process
E	0043066	biological_process	negative regulation of apoptotic process
E	0043087	biological_process	regulation of GTPase activity
E	0043410	biological_process	positive regulation of MAPK cascade
E	0043524	biological_process	negative regulation of neuron apoptotic process
E	0045471	biological_process	response to ethanol
E	0046620	biological_process	regulation of organ growth
E	0046688	biological_process	response to copper ion
E	0046716	biological_process	muscle cell cellular homeostasis
E	0046872	molecular_function	metal ion binding
E	0048538	biological_process	thymus development
E	0048678	biological_process	response to axon injury
E	0050665	biological_process	hydrogen peroxide biosynthetic process
E	0050728	biological_process	negative regulation of inflammatory response
E	0050766	biological_process	positive regulation of phagocytosis
E	0051087	molecular_function	protein-folding chaperone binding
E	0051093	biological_process	negative regulation of developmental process
E	0051881	biological_process	regulation of mitochondrial membrane potential
E	0060047	biological_process	heart contraction
E	0060052	biological_process	neurofilament cytoskeleton organization
E	0060087	biological_process	relaxation of vascular associated smooth muscle
E	0060088	biological_process	auditory receptor cell stereocilium organization
E	0070062	cellular_component	extracellular exosome
E	0071276	biological_process	cellular response to cadmium ion
E	0071318	biological_process	cellular response to ATP
E	0072593	biological_process	reactive oxygen species metabolic process
E	0097332	biological_process	response to antipsychotic drug
E	0099610	biological_process	action potential initiation
E	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
E	1904115	cellular_component	axon cytoplasm
E	2000242	biological_process	negative regulation of reproductive process
F	0000302	biological_process	response to reactive oxygen species
F	0000303	biological_process	response to superoxide
F	0001541	biological_process	ovarian follicle development
F	0001819	biological_process	positive regulation of cytokine production
F	0001890	biological_process	placenta development
F	0001895	biological_process	retina homeostasis
F	0001975	biological_process	response to amphetamine
F	0002262	biological_process	myeloid cell homeostasis
F	0004784	molecular_function	superoxide dismutase activity
F	0005507	molecular_function	copper ion binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005758	cellular_component	mitochondrial intermembrane space
F	0005759	cellular_component	mitochondrial matrix
F	0005764	cellular_component	lysosome
F	0005777	cellular_component	peroxisome
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006749	biological_process	glutathione metabolic process
F	0006801	biological_process	superoxide metabolic process
F	0006879	biological_process	intracellular iron ion homeostasis
F	0006915	biological_process	apoptotic process
F	0006979	biological_process	response to oxidative stress
F	0007283	biological_process	spermatogenesis
F	0007566	biological_process	embryo implantation
F	0007605	biological_process	sensory perception of sound
F	0007626	biological_process	locomotory behavior
F	0008089	biological_process	anterograde axonal transport
F	0008090	biological_process	retrograde axonal transport
F	0008217	biological_process	regulation of blood pressure
F	0008270	molecular_function	zinc ion binding
F	0008340	biological_process	determination of adult lifespan
F	0009408	biological_process	response to heat
F	0009410	biological_process	response to xenobiotic stimulus
F	0010467	biological_process	gene expression
F	0016209	molecular_function	antioxidant activity
F	0016491	molecular_function	oxidoreductase activity
F	0019226	biological_process	transmission of nerve impulse
F	0019228	biological_process	neuronal action potential
F	0019430	biological_process	removal of superoxide radicals
F	0019899	molecular_function	enzyme binding
F	0030141	cellular_component	secretory granule
F	0030346	molecular_function	protein phosphatase 2B binding
F	0031045	cellular_component	dense core granule
F	0031267	molecular_function	small GTPase binding
F	0031410	cellular_component	cytoplasmic vesicle
F	0031667	biological_process	response to nutrient levels
F	0032287	biological_process	peripheral nervous system myelin maintenance
F	0032839	cellular_component	dendrite cytoplasm
F	0032930	biological_process	positive regulation of superoxide anion generation
F	0032991	cellular_component	protein-containing complex
F	0033081	biological_process	regulation of T cell differentiation in thymus
F	0034465	biological_process	response to carbon monoxide
F	0034599	biological_process	cellular response to oxidative stress
F	0035234	biological_process	ectopic germ cell programmed cell death
F	0035865	biological_process	cellular response to potassium ion
F	0040014	biological_process	regulation of multicellular organism growth
F	0042542	biological_process	response to hydrogen peroxide
F	0042554	biological_process	superoxide anion generation
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0043025	cellular_component	neuronal cell body
F	0043065	biological_process	positive regulation of apoptotic process
F	0043066	biological_process	negative regulation of apoptotic process
F	0043087	biological_process	regulation of GTPase activity
F	0043410	biological_process	positive regulation of MAPK cascade
F	0043524	biological_process	negative regulation of neuron apoptotic process
F	0045471	biological_process	response to ethanol
F	0046620	biological_process	regulation of organ growth
F	0046688	biological_process	response to copper ion
F	0046716	biological_process	muscle cell cellular homeostasis
F	0046872	molecular_function	metal ion binding
F	0048538	biological_process	thymus development
F	0048678	biological_process	response to axon injury
F	0050665	biological_process	hydrogen peroxide biosynthetic process
F	0050728	biological_process	negative regulation of inflammatory response
F	0050766	biological_process	positive regulation of phagocytosis
F	0051087	molecular_function	protein-folding chaperone binding
F	0051093	biological_process	negative regulation of developmental process
F	0051881	biological_process	regulation of mitochondrial membrane potential
F	0060047	biological_process	heart contraction
F	0060052	biological_process	neurofilament cytoskeleton organization
F	0060087	biological_process	relaxation of vascular associated smooth muscle
F	0060088	biological_process	auditory receptor cell stereocilium organization
F	0070062	cellular_component	extracellular exosome
F	0071276	biological_process	cellular response to cadmium ion
F	0071318	biological_process	cellular response to ATP
F	0072593	biological_process	reactive oxygen species metabolic process
F	0097332	biological_process	response to antipsychotic drug
F	0099610	biological_process	action potential initiation
F	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
F	1904115	cellular_component	axon cytoplasm
F	2000242	biological_process	negative regulation of reproductive process
G	0000302	biological_process	response to reactive oxygen species
G	0000303	biological_process	response to superoxide
G	0001541	biological_process	ovarian follicle development
G	0001819	biological_process	positive regulation of cytokine production
G	0001890	biological_process	placenta development
G	0001895	biological_process	retina homeostasis
G	0001975	biological_process	response to amphetamine
G	0002262	biological_process	myeloid cell homeostasis
G	0004784	molecular_function	superoxide dismutase activity
G	0005507	molecular_function	copper ion binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005758	cellular_component	mitochondrial intermembrane space
G	0005759	cellular_component	mitochondrial matrix
G	0005764	cellular_component	lysosome
G	0005777	cellular_component	peroxisome
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0006749	biological_process	glutathione metabolic process
G	0006801	biological_process	superoxide metabolic process
G	0006879	biological_process	intracellular iron ion homeostasis
G	0006915	biological_process	apoptotic process
G	0006979	biological_process	response to oxidative stress
G	0007283	biological_process	spermatogenesis
G	0007566	biological_process	embryo implantation
G	0007605	biological_process	sensory perception of sound
G	0007626	biological_process	locomotory behavior
G	0008089	biological_process	anterograde axonal transport
G	0008090	biological_process	retrograde axonal transport
G	0008217	biological_process	regulation of blood pressure
G	0008270	molecular_function	zinc ion binding
G	0008340	biological_process	determination of adult lifespan
G	0009408	biological_process	response to heat
G	0009410	biological_process	response to xenobiotic stimulus
G	0010467	biological_process	gene expression
G	0016209	molecular_function	antioxidant activity
G	0016491	molecular_function	oxidoreductase activity
G	0019226	biological_process	transmission of nerve impulse
G	0019228	biological_process	neuronal action potential
G	0019430	biological_process	removal of superoxide radicals
G	0019899	molecular_function	enzyme binding
G	0030141	cellular_component	secretory granule
G	0030346	molecular_function	protein phosphatase 2B binding
G	0031045	cellular_component	dense core granule
G	0031267	molecular_function	small GTPase binding
G	0031410	cellular_component	cytoplasmic vesicle
G	0031667	biological_process	response to nutrient levels
G	0032287	biological_process	peripheral nervous system myelin maintenance
G	0032839	cellular_component	dendrite cytoplasm
G	0032930	biological_process	positive regulation of superoxide anion generation
G	0032991	cellular_component	protein-containing complex
G	0033081	biological_process	regulation of T cell differentiation in thymus
G	0034465	biological_process	response to carbon monoxide
G	0034599	biological_process	cellular response to oxidative stress
G	0035234	biological_process	ectopic germ cell programmed cell death
G	0035865	biological_process	cellular response to potassium ion
G	0040014	biological_process	regulation of multicellular organism growth
G	0042542	biological_process	response to hydrogen peroxide
G	0042554	biological_process	superoxide anion generation
G	0042802	molecular_function	identical protein binding
G	0042803	molecular_function	protein homodimerization activity
G	0043025	cellular_component	neuronal cell body
G	0043065	biological_process	positive regulation of apoptotic process
G	0043066	biological_process	negative regulation of apoptotic process
G	0043087	biological_process	regulation of GTPase activity
G	0043410	biological_process	positive regulation of MAPK cascade
G	0043524	biological_process	negative regulation of neuron apoptotic process
G	0045471	biological_process	response to ethanol
G	0046620	biological_process	regulation of organ growth
G	0046688	biological_process	response to copper ion
G	0046716	biological_process	muscle cell cellular homeostasis
G	0046872	molecular_function	metal ion binding
G	0048538	biological_process	thymus development
G	0048678	biological_process	response to axon injury
G	0050665	biological_process	hydrogen peroxide biosynthetic process
G	0050728	biological_process	negative regulation of inflammatory response
G	0050766	biological_process	positive regulation of phagocytosis
G	0051087	molecular_function	protein-folding chaperone binding
G	0051093	biological_process	negative regulation of developmental process
G	0051881	biological_process	regulation of mitochondrial membrane potential
G	0060047	biological_process	heart contraction
G	0060052	biological_process	neurofilament cytoskeleton organization
G	0060087	biological_process	relaxation of vascular associated smooth muscle
G	0060088	biological_process	auditory receptor cell stereocilium organization
G	0070062	cellular_component	extracellular exosome
G	0071276	biological_process	cellular response to cadmium ion
G	0071318	biological_process	cellular response to ATP
G	0072593	biological_process	reactive oxygen species metabolic process
G	0097332	biological_process	response to antipsychotic drug
G	0099610	biological_process	action potential initiation
G	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
G	1904115	cellular_component	axon cytoplasm
G	2000242	biological_process	negative regulation of reproductive process
H	0000302	biological_process	response to reactive oxygen species
H	0000303	biological_process	response to superoxide
H	0001541	biological_process	ovarian follicle development
H	0001819	biological_process	positive regulation of cytokine production
H	0001890	biological_process	placenta development
H	0001895	biological_process	retina homeostasis
H	0001975	biological_process	response to amphetamine
H	0002262	biological_process	myeloid cell homeostasis
H	0004784	molecular_function	superoxide dismutase activity
H	0005507	molecular_function	copper ion binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005758	cellular_component	mitochondrial intermembrane space
H	0005759	cellular_component	mitochondrial matrix
H	0005764	cellular_component	lysosome
H	0005777	cellular_component	peroxisome
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006749	biological_process	glutathione metabolic process
H	0006801	biological_process	superoxide metabolic process
H	0006879	biological_process	intracellular iron ion homeostasis
H	0006915	biological_process	apoptotic process
H	0006979	biological_process	response to oxidative stress
H	0007283	biological_process	spermatogenesis
H	0007566	biological_process	embryo implantation
H	0007605	biological_process	sensory perception of sound
H	0007626	biological_process	locomotory behavior
H	0008089	biological_process	anterograde axonal transport
H	0008090	biological_process	retrograde axonal transport
H	0008217	biological_process	regulation of blood pressure
H	0008270	molecular_function	zinc ion binding
H	0008340	biological_process	determination of adult lifespan
H	0009408	biological_process	response to heat
H	0009410	biological_process	response to xenobiotic stimulus
H	0010467	biological_process	gene expression
H	0016209	molecular_function	antioxidant activity
H	0016491	molecular_function	oxidoreductase activity
H	0019226	biological_process	transmission of nerve impulse
H	0019228	biological_process	neuronal action potential
H	0019430	biological_process	removal of superoxide radicals
H	0019899	molecular_function	enzyme binding
H	0030141	cellular_component	secretory granule
H	0030346	molecular_function	protein phosphatase 2B binding
H	0031045	cellular_component	dense core granule
H	0031267	molecular_function	small GTPase binding
H	0031410	cellular_component	cytoplasmic vesicle
H	0031667	biological_process	response to nutrient levels
H	0032287	biological_process	peripheral nervous system myelin maintenance
H	0032839	cellular_component	dendrite cytoplasm
H	0032930	biological_process	positive regulation of superoxide anion generation
H	0032991	cellular_component	protein-containing complex
H	0033081	biological_process	regulation of T cell differentiation in thymus
H	0034465	biological_process	response to carbon monoxide
H	0034599	biological_process	cellular response to oxidative stress
H	0035234	biological_process	ectopic germ cell programmed cell death
H	0035865	biological_process	cellular response to potassium ion
H	0040014	biological_process	regulation of multicellular organism growth
H	0042542	biological_process	response to hydrogen peroxide
H	0042554	biological_process	superoxide anion generation
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0043025	cellular_component	neuronal cell body
H	0043065	biological_process	positive regulation of apoptotic process
H	0043066	biological_process	negative regulation of apoptotic process
H	0043087	biological_process	regulation of GTPase activity
H	0043410	biological_process	positive regulation of MAPK cascade
H	0043524	biological_process	negative regulation of neuron apoptotic process
H	0045471	biological_process	response to ethanol
H	0046620	biological_process	regulation of organ growth
H	0046688	biological_process	response to copper ion
H	0046716	biological_process	muscle cell cellular homeostasis
H	0046872	molecular_function	metal ion binding
H	0048538	biological_process	thymus development
H	0048678	biological_process	response to axon injury
H	0050665	biological_process	hydrogen peroxide biosynthetic process
H	0050728	biological_process	negative regulation of inflammatory response
H	0050766	biological_process	positive regulation of phagocytosis
H	0051087	molecular_function	protein-folding chaperone binding
H	0051093	biological_process	negative regulation of developmental process
H	0051881	biological_process	regulation of mitochondrial membrane potential
H	0060047	biological_process	heart contraction
H	0060052	biological_process	neurofilament cytoskeleton organization
H	0060087	biological_process	relaxation of vascular associated smooth muscle
H	0060088	biological_process	auditory receptor cell stereocilium organization
H	0070062	cellular_component	extracellular exosome
H	0071276	biological_process	cellular response to cadmium ion
H	0071318	biological_process	cellular response to ATP
H	0072593	biological_process	reactive oxygen species metabolic process
H	0097332	biological_process	response to antipsychotic drug
H	0099610	biological_process	action potential initiation
H	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
H	1904115	cellular_component	axon cytoplasm
H	2000242	biological_process	negative regulation of reproductive process
I	0000302	biological_process	response to reactive oxygen species
I	0000303	biological_process	response to superoxide
I	0001541	biological_process	ovarian follicle development
I	0001819	biological_process	positive regulation of cytokine production
I	0001890	biological_process	placenta development
I	0001895	biological_process	retina homeostasis
I	0001975	biological_process	response to amphetamine
I	0002262	biological_process	myeloid cell homeostasis
I	0004784	molecular_function	superoxide dismutase activity
I	0005507	molecular_function	copper ion binding
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005758	cellular_component	mitochondrial intermembrane space
I	0005759	cellular_component	mitochondrial matrix
I	0005764	cellular_component	lysosome
I	0005777	cellular_component	peroxisome
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0006749	biological_process	glutathione metabolic process
I	0006801	biological_process	superoxide metabolic process
I	0006879	biological_process	intracellular iron ion homeostasis
I	0006915	biological_process	apoptotic process
I	0006979	biological_process	response to oxidative stress
I	0007283	biological_process	spermatogenesis
I	0007566	biological_process	embryo implantation
I	0007605	biological_process	sensory perception of sound
I	0007626	biological_process	locomotory behavior
I	0008089	biological_process	anterograde axonal transport
I	0008090	biological_process	retrograde axonal transport
I	0008217	biological_process	regulation of blood pressure
I	0008270	molecular_function	zinc ion binding
I	0008340	biological_process	determination of adult lifespan
I	0009408	biological_process	response to heat
I	0009410	biological_process	response to xenobiotic stimulus
I	0010467	biological_process	gene expression
I	0016209	molecular_function	antioxidant activity
I	0016491	molecular_function	oxidoreductase activity
I	0019226	biological_process	transmission of nerve impulse
I	0019228	biological_process	neuronal action potential
I	0019430	biological_process	removal of superoxide radicals
I	0019899	molecular_function	enzyme binding
I	0030141	cellular_component	secretory granule
I	0030346	molecular_function	protein phosphatase 2B binding
I	0031045	cellular_component	dense core granule
I	0031267	molecular_function	small GTPase binding
I	0031410	cellular_component	cytoplasmic vesicle
I	0031667	biological_process	response to nutrient levels
I	0032287	biological_process	peripheral nervous system myelin maintenance
I	0032839	cellular_component	dendrite cytoplasm
I	0032930	biological_process	positive regulation of superoxide anion generation
I	0032991	cellular_component	protein-containing complex
I	0033081	biological_process	regulation of T cell differentiation in thymus
I	0034465	biological_process	response to carbon monoxide
I	0034599	biological_process	cellular response to oxidative stress
I	0035234	biological_process	ectopic germ cell programmed cell death
I	0035865	biological_process	cellular response to potassium ion
I	0040014	biological_process	regulation of multicellular organism growth
I	0042542	biological_process	response to hydrogen peroxide
I	0042554	biological_process	superoxide anion generation
I	0042802	molecular_function	identical protein binding
I	0042803	molecular_function	protein homodimerization activity
I	0043025	cellular_component	neuronal cell body
I	0043065	biological_process	positive regulation of apoptotic process
I	0043066	biological_process	negative regulation of apoptotic process
I	0043087	biological_process	regulation of GTPase activity
I	0043410	biological_process	positive regulation of MAPK cascade
I	0043524	biological_process	negative regulation of neuron apoptotic process
I	0045471	biological_process	response to ethanol
I	0046620	biological_process	regulation of organ growth
I	0046688	biological_process	response to copper ion
I	0046716	biological_process	muscle cell cellular homeostasis
I	0046872	molecular_function	metal ion binding
I	0048538	biological_process	thymus development
I	0048678	biological_process	response to axon injury
I	0050665	biological_process	hydrogen peroxide biosynthetic process
I	0050728	biological_process	negative regulation of inflammatory response
I	0050766	biological_process	positive regulation of phagocytosis
I	0051087	molecular_function	protein-folding chaperone binding
I	0051093	biological_process	negative regulation of developmental process
I	0051881	biological_process	regulation of mitochondrial membrane potential
I	0060047	biological_process	heart contraction
I	0060052	biological_process	neurofilament cytoskeleton organization
I	0060087	biological_process	relaxation of vascular associated smooth muscle
I	0060088	biological_process	auditory receptor cell stereocilium organization
I	0070062	cellular_component	extracellular exosome
I	0071276	biological_process	cellular response to cadmium ion
I	0071318	biological_process	cellular response to ATP
I	0072593	biological_process	reactive oxygen species metabolic process
I	0097332	biological_process	response to antipsychotic drug
I	0099610	biological_process	action potential initiation
I	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
I	1904115	cellular_component	axon cytoplasm
I	2000242	biological_process	negative regulation of reproductive process
J	0000302	biological_process	response to reactive oxygen species
J	0000303	biological_process	response to superoxide
J	0001541	biological_process	ovarian follicle development
J	0001819	biological_process	positive regulation of cytokine production
J	0001890	biological_process	placenta development
J	0001895	biological_process	retina homeostasis
J	0001975	biological_process	response to amphetamine
J	0002262	biological_process	myeloid cell homeostasis
J	0004784	molecular_function	superoxide dismutase activity
J	0005507	molecular_function	copper ion binding
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005758	cellular_component	mitochondrial intermembrane space
J	0005759	cellular_component	mitochondrial matrix
J	0005764	cellular_component	lysosome
J	0005777	cellular_component	peroxisome
J	0005829	cellular_component	cytosol
J	0005886	cellular_component	plasma membrane
J	0006749	biological_process	glutathione metabolic process
J	0006801	biological_process	superoxide metabolic process
J	0006879	biological_process	intracellular iron ion homeostasis
J	0006915	biological_process	apoptotic process
J	0006979	biological_process	response to oxidative stress
J	0007283	biological_process	spermatogenesis
J	0007566	biological_process	embryo implantation
J	0007605	biological_process	sensory perception of sound
J	0007626	biological_process	locomotory behavior
J	0008089	biological_process	anterograde axonal transport
J	0008090	biological_process	retrograde axonal transport
J	0008217	biological_process	regulation of blood pressure
J	0008270	molecular_function	zinc ion binding
J	0008340	biological_process	determination of adult lifespan
J	0009408	biological_process	response to heat
J	0009410	biological_process	response to xenobiotic stimulus
J	0010467	biological_process	gene expression
J	0016209	molecular_function	antioxidant activity
J	0016491	molecular_function	oxidoreductase activity
J	0019226	biological_process	transmission of nerve impulse
J	0019228	biological_process	neuronal action potential
J	0019430	biological_process	removal of superoxide radicals
J	0019899	molecular_function	enzyme binding
J	0030141	cellular_component	secretory granule
J	0030346	molecular_function	protein phosphatase 2B binding
J	0031045	cellular_component	dense core granule
J	0031267	molecular_function	small GTPase binding
J	0031410	cellular_component	cytoplasmic vesicle
J	0031667	biological_process	response to nutrient levels
J	0032287	biological_process	peripheral nervous system myelin maintenance
J	0032839	cellular_component	dendrite cytoplasm
J	0032930	biological_process	positive regulation of superoxide anion generation
J	0032991	cellular_component	protein-containing complex
J	0033081	biological_process	regulation of T cell differentiation in thymus
J	0034465	biological_process	response to carbon monoxide
J	0034599	biological_process	cellular response to oxidative stress
J	0035234	biological_process	ectopic germ cell programmed cell death
J	0035865	biological_process	cellular response to potassium ion
J	0040014	biological_process	regulation of multicellular organism growth
J	0042542	biological_process	response to hydrogen peroxide
J	0042554	biological_process	superoxide anion generation
J	0042802	molecular_function	identical protein binding
J	0042803	molecular_function	protein homodimerization activity
J	0043025	cellular_component	neuronal cell body
J	0043065	biological_process	positive regulation of apoptotic process
J	0043066	biological_process	negative regulation of apoptotic process
J	0043087	biological_process	regulation of GTPase activity
J	0043410	biological_process	positive regulation of MAPK cascade
J	0043524	biological_process	negative regulation of neuron apoptotic process
J	0045471	biological_process	response to ethanol
J	0046620	biological_process	regulation of organ growth
J	0046688	biological_process	response to copper ion
J	0046716	biological_process	muscle cell cellular homeostasis
J	0046872	molecular_function	metal ion binding
J	0048538	biological_process	thymus development
J	0048678	biological_process	response to axon injury
J	0050665	biological_process	hydrogen peroxide biosynthetic process
J	0050728	biological_process	negative regulation of inflammatory response
J	0050766	biological_process	positive regulation of phagocytosis
J	0051087	molecular_function	protein-folding chaperone binding
J	0051093	biological_process	negative regulation of developmental process
J	0051881	biological_process	regulation of mitochondrial membrane potential
J	0060047	biological_process	heart contraction
J	0060052	biological_process	neurofilament cytoskeleton organization
J	0060087	biological_process	relaxation of vascular associated smooth muscle
J	0060088	biological_process	auditory receptor cell stereocilium organization
J	0070062	cellular_component	extracellular exosome
J	0071276	biological_process	cellular response to cadmium ion
J	0071318	biological_process	cellular response to ATP
J	0072593	biological_process	reactive oxygen species metabolic process
J	0097332	biological_process	response to antipsychotic drug
J	0099610	biological_process	action potential initiation
J	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
J	1904115	cellular_component	axon cytoplasm
J	2000242	biological_process	negative regulation of reproductive process
K	0000302	biological_process	response to reactive oxygen species
K	0000303	biological_process	response to superoxide
K	0001541	biological_process	ovarian follicle development
K	0001819	biological_process	positive regulation of cytokine production
K	0001890	biological_process	placenta development
K	0001895	biological_process	retina homeostasis
K	0001975	biological_process	response to amphetamine
K	0002262	biological_process	myeloid cell homeostasis
K	0004784	molecular_function	superoxide dismutase activity
K	0005507	molecular_function	copper ion binding
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005615	cellular_component	extracellular space
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005758	cellular_component	mitochondrial intermembrane space
K	0005759	cellular_component	mitochondrial matrix
K	0005764	cellular_component	lysosome
K	0005777	cellular_component	peroxisome
K	0005829	cellular_component	cytosol
K	0005886	cellular_component	plasma membrane
K	0006749	biological_process	glutathione metabolic process
K	0006801	biological_process	superoxide metabolic process
K	0006879	biological_process	intracellular iron ion homeostasis
K	0006915	biological_process	apoptotic process
K	0006979	biological_process	response to oxidative stress
K	0007283	biological_process	spermatogenesis
K	0007566	biological_process	embryo implantation
K	0007605	biological_process	sensory perception of sound
K	0007626	biological_process	locomotory behavior
K	0008089	biological_process	anterograde axonal transport
K	0008090	biological_process	retrograde axonal transport
K	0008217	biological_process	regulation of blood pressure
K	0008270	molecular_function	zinc ion binding
K	0008340	biological_process	determination of adult lifespan
K	0009408	biological_process	response to heat
K	0009410	biological_process	response to xenobiotic stimulus
K	0010467	biological_process	gene expression
K	0016209	molecular_function	antioxidant activity
K	0016491	molecular_function	oxidoreductase activity
K	0019226	biological_process	transmission of nerve impulse
K	0019228	biological_process	neuronal action potential
K	0019430	biological_process	removal of superoxide radicals
K	0019899	molecular_function	enzyme binding
K	0030141	cellular_component	secretory granule
K	0030346	molecular_function	protein phosphatase 2B binding
K	0031045	cellular_component	dense core granule
K	0031267	molecular_function	small GTPase binding
K	0031410	cellular_component	cytoplasmic vesicle
K	0031667	biological_process	response to nutrient levels
K	0032287	biological_process	peripheral nervous system myelin maintenance
K	0032839	cellular_component	dendrite cytoplasm
K	0032930	biological_process	positive regulation of superoxide anion generation
K	0032991	cellular_component	protein-containing complex
K	0033081	biological_process	regulation of T cell differentiation in thymus
K	0034465	biological_process	response to carbon monoxide
K	0034599	biological_process	cellular response to oxidative stress
K	0035234	biological_process	ectopic germ cell programmed cell death
K	0035865	biological_process	cellular response to potassium ion
K	0040014	biological_process	regulation of multicellular organism growth
K	0042542	biological_process	response to hydrogen peroxide
K	0042554	biological_process	superoxide anion generation
K	0042802	molecular_function	identical protein binding
K	0042803	molecular_function	protein homodimerization activity
K	0043025	cellular_component	neuronal cell body
K	0043065	biological_process	positive regulation of apoptotic process
K	0043066	biological_process	negative regulation of apoptotic process
K	0043087	biological_process	regulation of GTPase activity
K	0043410	biological_process	positive regulation of MAPK cascade
K	0043524	biological_process	negative regulation of neuron apoptotic process
K	0045471	biological_process	response to ethanol
K	0046620	biological_process	regulation of organ growth
K	0046688	biological_process	response to copper ion
K	0046716	biological_process	muscle cell cellular homeostasis
K	0046872	molecular_function	metal ion binding
K	0048538	biological_process	thymus development
K	0048678	biological_process	response to axon injury
K	0050665	biological_process	hydrogen peroxide biosynthetic process
K	0050728	biological_process	negative regulation of inflammatory response
K	0050766	biological_process	positive regulation of phagocytosis
K	0051087	molecular_function	protein-folding chaperone binding
K	0051093	biological_process	negative regulation of developmental process
K	0051881	biological_process	regulation of mitochondrial membrane potential
K	0060047	biological_process	heart contraction
K	0060052	biological_process	neurofilament cytoskeleton organization
K	0060087	biological_process	relaxation of vascular associated smooth muscle
K	0060088	biological_process	auditory receptor cell stereocilium organization
K	0070062	cellular_component	extracellular exosome
K	0071276	biological_process	cellular response to cadmium ion
K	0071318	biological_process	cellular response to ATP
K	0072593	biological_process	reactive oxygen species metabolic process
K	0097332	biological_process	response to antipsychotic drug
K	0099610	biological_process	action potential initiation
K	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
K	1904115	cellular_component	axon cytoplasm
K	2000242	biological_process	negative regulation of reproductive process
L	0000302	biological_process	response to reactive oxygen species
L	0000303	biological_process	response to superoxide
L	0001541	biological_process	ovarian follicle development
L	0001819	biological_process	positive regulation of cytokine production
L	0001890	biological_process	placenta development
L	0001895	biological_process	retina homeostasis
L	0001975	biological_process	response to amphetamine
L	0002262	biological_process	myeloid cell homeostasis
L	0004784	molecular_function	superoxide dismutase activity
L	0005507	molecular_function	copper ion binding
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005758	cellular_component	mitochondrial intermembrane space
L	0005759	cellular_component	mitochondrial matrix
L	0005764	cellular_component	lysosome
L	0005777	cellular_component	peroxisome
L	0005829	cellular_component	cytosol
L	0005886	cellular_component	plasma membrane
L	0006749	biological_process	glutathione metabolic process
L	0006801	biological_process	superoxide metabolic process
L	0006879	biological_process	intracellular iron ion homeostasis
L	0006915	biological_process	apoptotic process
L	0006979	biological_process	response to oxidative stress
L	0007283	biological_process	spermatogenesis
L	0007566	biological_process	embryo implantation
L	0007605	biological_process	sensory perception of sound
L	0007626	biological_process	locomotory behavior
L	0008089	biological_process	anterograde axonal transport
L	0008090	biological_process	retrograde axonal transport
L	0008217	biological_process	regulation of blood pressure
L	0008270	molecular_function	zinc ion binding
L	0008340	biological_process	determination of adult lifespan
L	0009408	biological_process	response to heat
L	0009410	biological_process	response to xenobiotic stimulus
L	0010467	biological_process	gene expression
L	0016209	molecular_function	antioxidant activity
L	0016491	molecular_function	oxidoreductase activity
L	0019226	biological_process	transmission of nerve impulse
L	0019228	biological_process	neuronal action potential
L	0019430	biological_process	removal of superoxide radicals
L	0019899	molecular_function	enzyme binding
L	0030141	cellular_component	secretory granule
L	0030346	molecular_function	protein phosphatase 2B binding
L	0031045	cellular_component	dense core granule
L	0031267	molecular_function	small GTPase binding
L	0031410	cellular_component	cytoplasmic vesicle
L	0031667	biological_process	response to nutrient levels
L	0032287	biological_process	peripheral nervous system myelin maintenance
L	0032839	cellular_component	dendrite cytoplasm
L	0032930	biological_process	positive regulation of superoxide anion generation
L	0032991	cellular_component	protein-containing complex
L	0033081	biological_process	regulation of T cell differentiation in thymus
L	0034465	biological_process	response to carbon monoxide
L	0034599	biological_process	cellular response to oxidative stress
L	0035234	biological_process	ectopic germ cell programmed cell death
L	0035865	biological_process	cellular response to potassium ion
L	0040014	biological_process	regulation of multicellular organism growth
L	0042542	biological_process	response to hydrogen peroxide
L	0042554	biological_process	superoxide anion generation
L	0042802	molecular_function	identical protein binding
L	0042803	molecular_function	protein homodimerization activity
L	0043025	cellular_component	neuronal cell body
L	0043065	biological_process	positive regulation of apoptotic process
L	0043066	biological_process	negative regulation of apoptotic process
L	0043087	biological_process	regulation of GTPase activity
L	0043410	biological_process	positive regulation of MAPK cascade
L	0043524	biological_process	negative regulation of neuron apoptotic process
L	0045471	biological_process	response to ethanol
L	0046620	biological_process	regulation of organ growth
L	0046688	biological_process	response to copper ion
L	0046716	biological_process	muscle cell cellular homeostasis
L	0046872	molecular_function	metal ion binding
L	0048538	biological_process	thymus development
L	0048678	biological_process	response to axon injury
L	0050665	biological_process	hydrogen peroxide biosynthetic process
L	0050728	biological_process	negative regulation of inflammatory response
L	0050766	biological_process	positive regulation of phagocytosis
L	0051087	molecular_function	protein-folding chaperone binding
L	0051093	biological_process	negative regulation of developmental process
L	0051881	biological_process	regulation of mitochondrial membrane potential
L	0060047	biological_process	heart contraction
L	0060052	biological_process	neurofilament cytoskeleton organization
L	0060087	biological_process	relaxation of vascular associated smooth muscle
L	0060088	biological_process	auditory receptor cell stereocilium organization
L	0070062	cellular_component	extracellular exosome
L	0071276	biological_process	cellular response to cadmium ion
L	0071318	biological_process	cellular response to ATP
L	0072593	biological_process	reactive oxygen species metabolic process
L	0097332	biological_process	response to antipsychotic drug
L	0099610	biological_process	action potential initiation
L	1902177	biological_process	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
L	1904115	cellular_component	axon cytoplasm
L	2000242	biological_process	negative regulation of reproductive process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU A 154

Chain	Residue
A	HIS46
A	HIS48
A	HIS63
A	HIS120
A	HOH2060

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 155

Chain	Residue
A	LYS136
A	HIS63
A	HIS71
A	HIS80
A	ASP83

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU B 154

Chain	Residue
B	HIS46
B	HIS48
B	HIS63
B	HIS120
B	HOH2062

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 155

Chain	Residue
B	HIS63
B	HIS71
B	HIS80
B	ASP83
B	LYS136

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU C 154

Chain	Residue
C	HIS46
C	HIS48
C	HIS63
C	HIS120
C	HOH2063

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 155

Chain	Residue
C	HIS63
C	HIS71
C	HIS80
C	ASP83
C	LYS136

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU D 154

Chain	Residue
D	HIS46
D	HIS48
D	HIS63
D	HIS120
D	HOH2063

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN D 155

Chain	Residue
D	HIS63
D	HIS71
D	HIS80
D	ASP83
D	LYS136

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU E 154

Chain	Residue
E	HIS46
E	HIS48
E	HIS63
E	HIS120
E	HOH2032

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN E 155

Chain	Residue
E	HIS63
E	HIS71
E	HIS80
E	ASP83
E	LYS136

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU F 154

Chain	Residue
F	HIS46
F	HIS48
F	HIS63
F	HIS120
F	HOH2018

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 155

Chain	Residue
F	HIS63
F	HIS71
F	HIS80
F	ASP83

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU G 154

Chain	Residue
G	HIS46
G	HIS48
G	HIS63
G	HIS120
G	HOH2030

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN G 155

Chain	Residue
G	HIS63
G	HIS71
G	HIS80
G	ASP83
G	LYS136

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU H 154

Chain	Residue
H	HIS46
H	HIS48
H	HIS63
H	HIS120
H	HOH2065

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN H 155

Chain	Residue
H	HIS63
H	HIS71
H	HIS80
H	ASP83
H	LYS136

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU I 154

Chain	Residue
I	HIS46
I	HIS48
I	HIS63
I	HIS120
I	HOH2031

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN I 155

Chain	Residue
I	HIS63
I	HIS71
I	HIS80
I	ASP83
I	LYS136

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU J 154

Chain	Residue
J	HIS46
J	HIS48
J	HIS63
J	HIS120
J	HOH2030

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN J 155

Chain	Residue
J	HIS63
J	HIS71
J	HIS80
J	ASP83

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU K 154

Chain	Residue
K	HIS48
K	HIS63
K	HIS120
K	HOH2021
K	HIS46

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN K 155

Chain	Residue
K	HIS63
K	HIS71
K	HIS80
K	ASP83
K	LYS136

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU L 154

Chain	Residue
L	HIS46
L	HIS48
L	HIS63
L	HIS120
L	HOH2023

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN L 155

Chain	Residue
L	HIS63
L	HIS71
L	HIS80
L	ASP83
L	LYS136

Functional Information from PROSITE/UniProt

site_id	PS00087
Number of Residues	11
Details	SOD_CU_ZN_1 Copper/Zinc superoxide dismutase signature 1. GFHVHEfGDnT

Chain	Residue	Details
A	GLY44-THR54

site_id	PS00332
Number of Residues	12
Details	SOD_CU_ZN_2 Copper/Zinc superoxide dismutase signature 2. GNAGsRlACgvI

Chain	Residue	Details
A	GLY138-ILE149

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12963370","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17548825","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20727846","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	12
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"1463506","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7002610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	36
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P08228","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P07632","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P08228","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	12
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"24140062","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	12
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P08228","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	12
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"22496122","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	24
Details	Cross-link: {"description":"1-(tryptophan-3-yl)-tryptophan (Trp-Trp) (interchain with W-33)","evidences":[{"source":"PubMed","id":"20600836","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
A	ARG143
A	HIS63

site_id	CSA10
Number of Residues	2
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
J	ARG143
J	HIS63

site_id	CSA11
Number of Residues	2
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
K	ARG143
K	HIS63

site_id	CSA12
Number of Residues	2
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
L	ARG143
L	HIS63

site_id	CSA13
Number of Residues	1
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
A	HIS63

site_id	CSA14
Number of Residues	1
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
B	HIS63

site_id	CSA15
Number of Residues	1
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
C	HIS63

site_id	CSA16
Number of Residues	1
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
D	HIS63

site_id	CSA17
Number of Residues	1
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
E	HIS63

site_id	CSA18
Number of Residues	1
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
F	HIS63

site_id	CSA19
Number of Residues	1
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
G	HIS63

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
B	ARG143
B	HIS63

site_id	CSA20
Number of Residues	1
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
H	HIS63

site_id	CSA21
Number of Residues	1
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
I	HIS63

site_id	CSA22
Number of Residues	1
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
J	HIS63

site_id	CSA23
Number of Residues	1
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
K	HIS63

site_id	CSA24
Number of Residues	1
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
L	HIS63

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
C	ARG143
C	HIS63

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
D	ARG143
D	HIS63

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
E	ARG143
E	HIS63

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
F	ARG143
F	HIS63

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
G	ARG143
G	HIS63

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
H	ARG143
H	HIS63

site_id	CSA9
Number of Residues	2
Details	Annotated By Reference To The Literature 2jcw

Chain	Residue	Details
I	ARG143
I	HIS63

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)