1UX6

Structure of a thrombospondin C-terminal fragment reveals a novel calcium core in the type 3 repeats

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
A	0005576	cellular_component	extracellular region
A	0007155	biological_process	cell adhesion

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B2001

Chain	Residue
A	ASP917
A	ASP919
A	ASP926
A	CYS928
A	ASN931
A	ILE934

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B2002

Chain	Residue
A	VAL921
A	ASP926
A	HOH2154
A	ASP915
A	ASP917
A	ASP919

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B2003

Chain	Residue
A	ASP902
A	ASP904
A	ASP906
A	ARG908
A	HOH2239
A	HOH2150

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B2004

Chain	Residue
A	ASP879
A	ASP881
A	ASP883
A	ILE885
A	ASP890
A	HOH2136

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B2005

Chain	Residue
A	ASP881
A	ASP883
A	ASP890
A	CYS892
A	VAL895
A	ASN897

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B2006

Chain	Residue
A	ASP868
A	ASP870
A	ASP877
A	ASP879
A	ASN882
A	HOH2294

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B2007

Chain	Residue
A	ASP866
A	ASP868
A	ASP870
A	LYS872
A	ASP877
A	HOH2118

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B2008

Chain	Residue
A	ASP874
A	ASP877
A	ASP880
A	ASP887
A	HOH2280
A	HOH2142

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B2009

Chain	Residue
A	ASP845
A	ASP847
A	ASP854
A	CYS856
A	VAL859
A	ASN861

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B2010

Chain	Residue
A	ASP843
A	ASP845
A	ASP847
A	HIS849
A	ASP854
A	HOH2122

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B2011

Chain	Residue
A	ASP830
A	ASP832
A	ASP839
A	ASN841
A	HOH2241
A	HOH2183

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B2012

Chain	Residue
A	ASP828
A	ASP830
A	ASP832
A	ILE834
A	ASP839
A	HOH2110

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B2013

Chain	Residue
A	ASP825
A	ASN973
A	ASP1001
A	ASP1003
A	SER1136

---

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA B2014

Chain	Residue
A	GLU999
A	ASP1001
A	GLN1024
A	ASP1086
A	HOH2184
A	HOH2244
A	HOH2179

---

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B2015

Chain	Residue
A	ASP825
A	ASP1001
A	ASP1002
A	ASP1003
A	GLN1027
A	HOH2203

---

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B2016

Chain	Residue
A	ASP948
A	GLY951
A	ASP956
A	ASP975
A	HOH2187
A	HOH2149

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	37
Details	Repeat: {"description":"TSP type-3 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	35
Details	Repeat: {"description":"TSP type-3 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	35
Details	Repeat: {"description":"TSP type-3 8"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	95
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Motif: {"description":"Cell attachment site","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	42
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15014436","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16740002","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---