1UUO
Rat dihydroorotate dehydrogenase (DHOD)in complex with brequinar
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0007565 | biological_process | female pregnancy |
| A | 0007595 | biological_process | lactation |
| A | 0009220 | biological_process | pyrimidine ribonucleotide biosynthetic process |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0010181 | molecular_function | FMN binding |
| A | 0016020 | cellular_component | membrane |
| A | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| A | 0031000 | biological_process | response to caffeine |
| A | 0042594 | biological_process | response to starvation |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0043065 | biological_process | positive regulation of apoptotic process |
| A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| A | 0048038 | molecular_function | quinone binding |
| A | 0048039 | molecular_function | ubiquinone binding |
| A | 0072528 | biological_process | pyrimidine-containing compound biosynthetic process |
| A | 0090140 | biological_process | regulation of mitochondrial fission |
| A | 0106430 | molecular_function | dihydroorotate dehydrogenase (quinone) activity |
| A | 1903576 | biological_process | response to L-arginine |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NI A1400 |
| Chain | Residue |
| A | GLY203 |
| A | PRO204 |
| A | ALA206 |
| A | THR247 |
| A | ARG248 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE BRF A1397 |
| Chain | Residue |
| A | ALA55 |
| A | HIS56 |
| A | ALA59 |
| A | VAL134 |
| A | ARG136 |
| A | TYR356 |
| A | ILE360 |
| A | PRO364 |
| A | LEU42 |
| A | MET43 |
| A | GLN47 |
| A | PRO52 |
| site_id | AC3 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE FMN A1398 |
| Chain | Residue |
| A | ALA95 |
| A | ALA96 |
| A | GLY97 |
| A | LYS100 |
| A | GLY119 |
| A | SER120 |
| A | ASN145 |
| A | ASN181 |
| A | ASN212 |
| A | LYS255 |
| A | THR283 |
| A | ASN284 |
| A | SER305 |
| A | GLY306 |
| A | VAL333 |
| A | GLY334 |
| A | GLY335 |
| A | LEU355 |
| A | TYR356 |
| A | THR357 |
| A | ORO1399 |
| A | HOH2025 |
| A | HOH2034 |
| A | HOH2041 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE ORO A1399 |
| Chain | Residue |
| A | LYS100 |
| A | ASN145 |
| A | TYR147 |
| A | GLY148 |
| A | PHE149 |
| A | ASN212 |
| A | SER215 |
| A | ASN284 |
| A | THR285 |
| A | FMN1398 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 11 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15044733","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 7 |
| Details | Binding site: {} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1h7x |
| Chain | Residue | Details |
| A | SER215 | |
| A | PHE149 | |
| A | LYS255 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1h7x |
| Chain | Residue | Details |
| A | SER215 |
