1UUO

Rat dihydroorotate dehydrogenase (DHOD)in complex with brequinar

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004151	molecular_function	dihydroorotase activity
A	0004152	molecular_function	dihydroorotate dehydrogenase activity
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006225	biological_process	UDP biosynthetic process
A	0007565	biological_process	female pregnancy
A	0007595	biological_process	lactation
A	0009220	biological_process	pyrimidine ribonucleotide biosynthetic process
A	0009410	biological_process	response to xenobiotic stimulus
A	0010181	molecular_function	FMN binding
A	0014070	biological_process	response to organic cyclic compound
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016627	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors
A	0031000	biological_process	response to caffeine
A	0042594	biological_process	response to starvation
A	0043025	cellular_component	neuronal cell body
A	0043065	biological_process	positive regulation of apoptotic process
A	0044205	biological_process	'de novo' UMP biosynthetic process
A	0048038	molecular_function	quinone binding
A	0048039	molecular_function	ubiquinone binding
A	0090140	biological_process	regulation of mitochondrial fission
A	0106430	molecular_function	dihydroorotate dehydrogenase (quinone) activity
A	1903576	biological_process	response to L-arginine

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NI A1400

Chain	Residue
A	GLY203
A	PRO204
A	ALA206
A	THR247
A	ARG248

---

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE BRF A1397

Chain	Residue
A	ALA55
A	HIS56
A	ALA59
A	VAL134
A	ARG136
A	TYR356
A	ILE360
A	PRO364
A	LEU42
A	MET43
A	GLN47
A	PRO52

---

site_id	AC3
Number of Residues	24
Details	BINDING SITE FOR RESIDUE FMN A1398

Chain	Residue
A	ALA95
A	ALA96
A	GLY97
A	LYS100
A	GLY119
A	SER120
A	ASN145
A	ASN181
A	ASN212
A	LYS255
A	THR283
A	ASN284
A	SER305
A	GLY306
A	VAL333
A	GLY334
A	GLY335
A	LEU355
A	TYR356
A	THR357
A	ORO1399
A	HOH2025
A	HOH2034
A	HOH2041

---

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ORO A1399

Chain	Residue
A	LYS100
A	ASN145
A	TYR147
A	GLY148
A	PHE149
A	ASN212
A	SER215
A	ASN284
A	THR285
A	FMN1398

---

Functional Information from PROSITE/UniProt

site_id	PS00911
Number of Residues	20
Details	DHODEHASE_1 Dihydroorotate dehydrogenase signature 1. GfvevGSVTpqpQeGNprPR

Chain	Residue	Details
A	GLY114-ARG133

---

site_id	PS00912
Number of Residues	21
Details	DHODEHASE_2 Dihydroorotate dehydrogenase signature 2. IIGvGGVsSgqdAleKIqAGA

Chain	Residue	Details
A	ILE330-ALA350

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	364
Details	TOPO_DOM: Mitochondrial matrix

Chain	Residue	Details
A	THR32-ARG396

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000250

Chain	Residue	Details
A	SER215

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:15044733

Chain	Residue	Details
A	ALA96
A	SER120
A	ASN181
A	LYS255
A	THR283
A	GLY306
A	GLY335
A	TYR356

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING:

Chain	Residue	Details
A	LYS100
A	ASN145
A	ASN212
A	ASN284

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1h7x

Chain	Residue	Details
A	SER215
A	PHE149
A	LYS255

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1h7x

Chain	Residue	Details
A	SER215

---