1USH
5'-NUCLEOTIDASE FROM E. COLI
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 600 |
| Chain | Residue |
| A | ASP84 |
| A | GLN254 |
| A | ZN601 |
| A | CO3602 |
| A | ASP41 |
| A | HIS43 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 601 |
| Chain | Residue |
| A | ASP84 |
| A | ASN116 |
| A | HIS217 |
| A | HIS252 |
| A | ZN600 |
| A | CO3602 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE CO3 A 602 |
| Chain | Residue |
| A | ASP41 |
| A | ASP84 |
| A | ASN116 |
| A | HIS117 |
| A | HIS252 |
| A | GLN254 |
| A | THR518 |
| A | GLY519 |
| A | ZN600 |
| A | ZN601 |
| A | HOH1189 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 603 |
| Chain | Residue |
| A | ARG375 |
| A | ARG379 |
| A | ARG410 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 604 |
| Chain | Residue |
| A | TRP47 |
| A | ARG48 |
| A | HOH908 |
| A | HOH931 |
| A | HOH1147 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 605 |
| Chain | Residue |
| A | ASN342 |
| A | GLN343 |
| A | HOH628 |
| A | HOH945 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 606 |
| Chain | Residue |
| A | LYS68 |
| A | GLY148 |
| A | ARG190 |
| A | HOH862 |
| A | HOH975 |
| A | HOH1024 |
| A | HOH1183 |
| site_id | ZNB |
| Number of Residues | 7 |
| Details | ZN BINDING SITE |
| Chain | Residue |
| A | ASP41 |
| A | HIS43 |
| A | ASP84 |
| A | ASN116 |
| A | HIS217 |
| A | HIS252 |
| A | GLN254 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 9 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ASP41 | |
| A | HIS43 | |
| A | ASP84 | |
| A | ASN116 | |
| A | HIS217 | |
| A | HIS252 | |
| A | GLN254 | |
| A | ARG375 | |
| A | PHE498 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Transition state stabilizer |
| Chain | Residue | Details |
| A | HIS117 | |
| A | ASP120 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | a catalytic site defined by CSA, PubMed 10331872, 11491293 |
| Chain | Residue | Details |
| A | ARG375 | |
| A | ASP120 | |
| A | ARG410 | |
| A | HIS117 | |
| A | ARG379 | |
| A | ASN116 |
| site_id | MCSA1 |
| Number of Residues | 12 |
| Details | M-CSA 611 |
| Chain | Residue | Details |
| A | ASP41 | metal ligand |
| A | ARG375 | electrostatic stabiliser, increase acidity, increase electrophilicity |
| A | ARG379 | electrostatic stabiliser, increase acidity, increase electrophilicity |
| A | ARG410 | electrostatic stabiliser, increase acidity, increase electrophilicity |
| A | HIS43 | metal ligand |
| A | ASP84 | metal ligand |
| A | ASN116 | electrostatic stabiliser, metal ligand |
| A | HIS117 | electrostatic stabiliser, increase nucleophilicity, metal ligand, proton acceptor |
| A | ASP120 | electrostatic stabiliser, increase basicity |
| A | HIS217 | metal ligand |
| A | HIS252 | metal ligand |
| A | GLN254 | metal ligand |
