1U7W
Phosphopantothenoylcysteine synthetase from E. coli, CTP-complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004632 | molecular_function | phosphopantothenate--cysteine ligase activity |
| A | 0004633 | molecular_function | phosphopantothenoylcysteine decarboxylase activity |
| A | 0010181 | molecular_function | FMN binding |
| A | 0015937 | biological_process | coenzyme A biosynthetic process |
| A | 0015941 | biological_process | pantothenate catabolic process |
| B | 0004632 | molecular_function | phosphopantothenate--cysteine ligase activity |
| B | 0004633 | molecular_function | phosphopantothenoylcysteine decarboxylase activity |
| B | 0010181 | molecular_function | FMN binding |
| B | 0015937 | biological_process | coenzyme A biosynthetic process |
| B | 0015941 | biological_process | pantothenate catabolic process |
| C | 0004632 | molecular_function | phosphopantothenate--cysteine ligase activity |
| C | 0004633 | molecular_function | phosphopantothenoylcysteine decarboxylase activity |
| C | 0010181 | molecular_function | FMN binding |
| C | 0015937 | biological_process | coenzyme A biosynthetic process |
| C | 0015941 | biological_process | pantothenate catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 501 |
| Chain | Residue |
| A | ASP279 |
| A | CTP500 |
| A | HOH2502 |
| A | HOH2503 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 1501 |
| Chain | Residue |
| A | LYS289 |
| B | ASP279 |
| B | CTP1500 |
| B | HOH2504 |
| B | HOH2505 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA C 2501 |
| Chain | Residue |
| C | ASP279 |
| C | CTP2500 |
| C | HOH2506 |
| C | HOH2507 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE CTP A 500 |
| Chain | Residue |
| A | HOH32 |
| A | GLY273 |
| A | ALA275 |
| A | VAL277 |
| A | ASP279 |
| A | PRO308 |
| A | ASP309 |
| A | ILE310 |
| A | VAL311 |
| A | GLY326 |
| A | PHE327 |
| A | LYS341 |
| A | LYS345 |
| A | CA501 |
| A | HOH2503 |
| B | LYS289 |
| site_id | AC5 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE CTP B 1500 |
| Chain | Residue |
| A | LYS289 |
| B | HOH126 |
| B | HOH138 |
| B | GLY273 |
| B | ALA275 |
| B | VAL277 |
| B | ASP279 |
| B | PRO308 |
| B | ASP309 |
| B | ILE310 |
| B | VAL311 |
| B | GLY326 |
| B | PHE327 |
| B | LYS341 |
| B | LYS345 |
| B | CA1501 |
| B | HOH2505 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE CTP C 2500 |
| Chain | Residue |
| C | HOH68 |
| C | HOH118 |
| C | GLY273 |
| C | ALA275 |
| C | VAL277 |
| C | ASP279 |
| C | PRO308 |
| C | ASP309 |
| C | ILE310 |
| C | VAL311 |
| C | PHE327 |
| C | LYS341 |
| C | LYS345 |
| C | CA2501 |
| C | HOH2507 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 29 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_02225","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15530362","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1U7W","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 1 |
| Details | M-CSA 772 |
| Chain | Residue | Details |
| A | ASP210 | activator, electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 1 |
| Details | M-CSA 772 |
| Chain | Residue | Details |
| B | ASP210 | activator, electrostatic stabiliser |
| site_id | MCSA3 |
| Number of Residues | 1 |
| Details | M-CSA 772 |
| Chain | Residue | Details |
| C | ASP210 | activator, electrostatic stabiliser |
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1u7u |
| Chain | Residue | Details |
| A | ASP210 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1u7u |
| Chain | Residue | Details |
| B | ASP210 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1u7u |
| Chain | Residue | Details |
| C | ASP210 |
