1U74

Electron Transfer Complex between cytochrome C and cytochrome C peroxidase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0006979	biological_process	response to oxidative stress
A	0020037	molecular_function	heme binding
A	0034599	biological_process	cellular response to oxidative stress
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005758	cellular_component	mitochondrial intermembrane space
B	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
B	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
B	0009055	molecular_function	electron transfer activity
B	0020037	molecular_function	heme binding
B	0046872	molecular_function	metal ion binding
B	0070469	cellular_component	respirasome
B	1901612	molecular_function	cardiolipin binding
C	0004601	molecular_function	peroxidase activity
C	0006979	biological_process	response to oxidative stress
C	0020037	molecular_function	heme binding
C	0034599	biological_process	cellular response to oxidative stress
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005758	cellular_component	mitochondrial intermembrane space
D	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
D	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
D	0009055	molecular_function	electron transfer activity
D	0020037	molecular_function	heme binding
D	0046872	molecular_function	metal ion binding
D	0070469	cellular_component	respirasome
D	1901612	molecular_function	cardiolipin binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 C 2201

Chain	Residue
C	ARG48
C	TRP51
C	HIS52
C	HIS175
C	ZNH1201
C	HOH1716

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 A 2202

Chain	Residue
A	ZNH1001
A	HOH1724
A	ARG48
A	TRP51
A	HIS52

---

site_id	AC3
Number of Residues	21
Details	BINDING SITE FOR RESIDUE ZNH A 1001

Chain	Residue
A	PRO44
A	VAL45
A	VAL47
A	ARG48
A	TRP51
A	PRO145
A	LEU171
A	ALA174
A	HIS175
A	LEU177
A	GLY178
A	LYS179
A	THR180
A	HIS181
A	ASN184
A	SER185
A	TRP191
A	PHE266
A	HOH1438
A	HOH1725
A	PO42202

---

site_id	AC4
Number of Residues	22
Details	BINDING SITE FOR RESIDUE ZNH C 1201

Chain	Residue
C	PRO44
C	VAL45
C	VAL47
C	ARG48
C	TRP51
C	ASP146
C	LEU171
C	MET172
C	ALA174
C	HIS175
C	LEU177
C	GLY178
C	LYS179
C	THR180
C	HIS181
C	ASN184
C	SER185
C	TRP191
C	LEU232
C	PHE266
C	HOH1714
C	PO42201

---

site_id	AC5
Number of Residues	20
Details	BINDING SITE FOR RESIDUE HEM B 1101

Chain	Residue
B	ARG18
B	CYS19
B	CYS22
B	HIS23
B	VAL33
B	ARG43
B	SER45
B	GLY46
B	TYR51
B	TYR53
B	THR54
B	ASN57
B	TRP64
B	MET69
B	TYR72
B	LEU73
B	THR83
B	LYS84
B	MET85
B	PHE87

---

site_id	AC6
Number of Residues	24
Details	BINDING SITE FOR RESIDUE HEM D 1301

Chain	Residue
D	ARG18
D	CYS19
D	GLN21
D	CYS22
D	HIS23
D	VAL33
D	GLY34
D	PRO35
D	LEU37
D	ILE40
D	ARG43
D	SER45
D	GLY46
D	TYR51
D	TYR53
D	THR54
D	ASN57
D	TRP64
D	MET69
D	THR83
D	LYS84
D	MET85
D	LEU99
D	HOH1712

---

Functional Information from PROSITE/UniProt

site_id	PS00435
Number of Residues	11
Details	PEROXIDASE_1 Peroxidases proximal heme-ligand signature. EVVALMGAHAL

Chain	Residue	Details
A	GLU167-LEU177

---

site_id	PS00436
Number of Residues	12
Details	PEROXIDASE_2 Peroxidases active site signature. GPvlVRLaWHIS

Chain	Residue	Details
A	GLY43-SER54

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: covalent => ECO:0000269|PubMed:11880631, ECO:0000269|PubMed:18390544, ECO:0007744|PDB:1KYO, ECO:0007744|PDB:3CX5

Chain	Residue	Details
B	LEU20
B	HIS23
D	LEU20
D	HIS23

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: axial binding residue => ECO:0000269|PubMed:11880631, ECO:0000269|PubMed:18390544, ECO:0007744|PDB:1KYO, ECO:0007744|PDB:3CX5

Chain	Residue	Details
B	THR24
B	ALA86
D	THR24
D	ALA86

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6,N6,N6-trimethyllysine; by CTM1 => ECO:0000269|PubMed:10791961, ECO:0000269|PubMed:11880631, ECO:0007744|PDB:1KYO

Chain	Residue	Details
B	LYS78
D	LYS78

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6,N6,N6-trimethyllysine => ECO:0000269|PubMed:10821864, ECO:0000269|PubMed:18390544

Chain	Residue	Details
B	TYR79
D	TYR79

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18407956

Chain	Residue	Details
A	TYR153
C	TYR153

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1apx

Chain	Residue	Details
A	ARG48
A	HIS52
A	ASN82

---

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1apx

Chain	Residue	Details
C	ARG48
C	HIS52
C	ASN82

---

site_id	MCSA1
Number of Residues	3
Details	M-CSA 709

Chain	Residue	Details
A	ARG48	electrostatic stabiliser
A	HIS52	electrostatic stabiliser, proton acceptor, proton donor
A	TRP191	single electron acceptor, single electron donor

---

site_id	MCSA2
Number of Residues	3
Details	M-CSA 709

Chain	Residue	Details
C	ARG48	electrostatic stabiliser
C	HIS52	electrostatic stabiliser, proton acceptor, proton donor
C	TRP191	single electron acceptor, single electron donor

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