Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1U6J

The Structure of native coenzyme F420-dependent methylenetetrahydromethanopterin dehydrogenase at 2.4A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006730	biological_process	one-carbon metabolic process
A	0008901	molecular_function	ferredoxin hydrogenase activity
A	0015948	biological_process	methanogenesis
A	0016491	molecular_function	oxidoreductase activity
A	0019386	biological_process	methanogenesis, from carbon dioxide
A	0030268	molecular_function	methylenetetrahydromethanopterin dehydrogenase activity
B	0006730	biological_process	one-carbon metabolic process
B	0008901	molecular_function	ferredoxin hydrogenase activity
B	0015948	biological_process	methanogenesis
B	0016491	molecular_function	oxidoreductase activity
B	0019386	biological_process	methanogenesis, from carbon dioxide
B	0030268	molecular_function	methylenetetrahydromethanopterin dehydrogenase activity
C	0006730	biological_process	one-carbon metabolic process
C	0008901	molecular_function	ferredoxin hydrogenase activity
C	0015948	biological_process	methanogenesis
C	0016491	molecular_function	oxidoreductase activity
C	0019386	biological_process	methanogenesis, from carbon dioxide
C	0030268	molecular_function	methylenetetrahydromethanopterin dehydrogenase activity
D	0006730	biological_process	one-carbon metabolic process
D	0008901	molecular_function	ferredoxin hydrogenase activity
D	0015948	biological_process	methanogenesis
D	0016491	molecular_function	oxidoreductase activity
D	0019386	biological_process	methanogenesis, from carbon dioxide
D	0030268	molecular_function	methylenetetrahydromethanopterin dehydrogenase activity
E	0006730	biological_process	one-carbon metabolic process
E	0008901	molecular_function	ferredoxin hydrogenase activity
E	0015948	biological_process	methanogenesis
E	0016491	molecular_function	oxidoreductase activity
E	0019386	biological_process	methanogenesis, from carbon dioxide
E	0030268	molecular_function	methylenetetrahydromethanopterin dehydrogenase activity
F	0006730	biological_process	one-carbon metabolic process
F	0008901	molecular_function	ferredoxin hydrogenase activity
F	0015948	biological_process	methanogenesis
F	0016491	molecular_function	oxidoreductase activity
F	0019386	biological_process	methanogenesis, from carbon dioxide
F	0030268	molecular_function	methylenetetrahydromethanopterin dehydrogenase activity
G	0006730	biological_process	one-carbon metabolic process
G	0008901	molecular_function	ferredoxin hydrogenase activity
G	0015948	biological_process	methanogenesis
G	0016491	molecular_function	oxidoreductase activity
G	0019386	biological_process	methanogenesis, from carbon dioxide
G	0030268	molecular_function	methylenetetrahydromethanopterin dehydrogenase activity
H	0006730	biological_process	one-carbon metabolic process
H	0008901	molecular_function	ferredoxin hydrogenase activity
H	0015948	biological_process	methanogenesis
H	0016491	molecular_function	oxidoreductase activity
H	0019386	biological_process	methanogenesis, from carbon dioxide
H	0030268	molecular_function	methylenetetrahydromethanopterin dehydrogenase activity
I	0006730	biological_process	one-carbon metabolic process
I	0008901	molecular_function	ferredoxin hydrogenase activity
I	0015948	biological_process	methanogenesis
I	0016491	molecular_function	oxidoreductase activity
I	0019386	biological_process	methanogenesis, from carbon dioxide
I	0030268	molecular_function	methylenetetrahydromethanopterin dehydrogenase activity
J	0006730	biological_process	one-carbon metabolic process
J	0008901	molecular_function	ferredoxin hydrogenase activity
J	0015948	biological_process	methanogenesis
J	0016491	molecular_function	oxidoreductase activity
J	0019386	biological_process	methanogenesis, from carbon dioxide
J	0030268	molecular_function	methylenetetrahydromethanopterin dehydrogenase activity
K	0006730	biological_process	one-carbon metabolic process
K	0008901	molecular_function	ferredoxin hydrogenase activity
K	0015948	biological_process	methanogenesis
K	0016491	molecular_function	oxidoreductase activity
K	0019386	biological_process	methanogenesis, from carbon dioxide
K	0030268	molecular_function	methylenetetrahydromethanopterin dehydrogenase activity
L	0006730	biological_process	one-carbon metabolic process
L	0008901	molecular_function	ferredoxin hydrogenase activity
L	0015948	biological_process	methanogenesis
L	0016491	molecular_function	oxidoreductase activity
L	0019386	biological_process	methanogenesis, from carbon dioxide
L	0030268	molecular_function	methylenetetrahydromethanopterin dehydrogenase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 6001

Chain	Residue
A	HOH9008
A	HOH9010
A	HOH9011
A	HOH9013
A	HOH9014
L	ASP226

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 6002

Chain	Residue
A	HOH9089
A	HOH9090
A	HOH9091
A	HOH8387
A	HOH9087
A	HOH9088

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 6003

Chain	Residue
B	HOH9009
B	HOH9015
B	HOH9017
B	HOH9018
B	HOH9019
C	ASP226

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 6004

Chain	Residue
B	GLU175
B	HOH8239
B	HOH9092
C	ARG229
C	HOH8238

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG G 6005

Chain	Residue
G	HOH8421
G	HOH9020
G	HOH9021
G	HOH9023
G	HOH9024
G	HOH9025

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG G 6006

Chain	Residue
G	GLU91
G	HOH8021
G	HOH8235
G	HOH8236
G	HOH8243

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG H 6007

Chain	Residue
H	GLU175
H	HOH9028
H	HOH9029
H	HOH9030
I	ARG229
I	HOH8261

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG H 6008

Chain	Residue
H	HOH8240
H	HOH9102
H	HOH9104
H	HOH9105
I	ASP226

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)