1U6I

The Structure of native coenzyme F420-dependent methylenetetrahydromethanopterin dehydrogenase at 2.2A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006730	biological_process	one-carbon metabolic process
A	0008901	molecular_function	ferredoxin hydrogenase activity
A	0015948	biological_process	methanogenesis
A	0016491	molecular_function	oxidoreductase activity
A	0019386	biological_process	methanogenesis, from carbon dioxide
A	0030268	molecular_function	methylenetetrahydromethanopterin dehydrogenase activity
B	0006730	biological_process	one-carbon metabolic process
B	0008901	molecular_function	ferredoxin hydrogenase activity
B	0015948	biological_process	methanogenesis
B	0016491	molecular_function	oxidoreductase activity
B	0019386	biological_process	methanogenesis, from carbon dioxide
B	0030268	molecular_function	methylenetetrahydromethanopterin dehydrogenase activity
C	0006730	biological_process	one-carbon metabolic process
C	0008901	molecular_function	ferredoxin hydrogenase activity
C	0015948	biological_process	methanogenesis
C	0016491	molecular_function	oxidoreductase activity
C	0019386	biological_process	methanogenesis, from carbon dioxide
C	0030268	molecular_function	methylenetetrahydromethanopterin dehydrogenase activity
D	0006730	biological_process	one-carbon metabolic process
D	0008901	molecular_function	ferredoxin hydrogenase activity
D	0015948	biological_process	methanogenesis
D	0016491	molecular_function	oxidoreductase activity
D	0019386	biological_process	methanogenesis, from carbon dioxide
D	0030268	molecular_function	methylenetetrahydromethanopterin dehydrogenase activity
E	0006730	biological_process	one-carbon metabolic process
E	0008901	molecular_function	ferredoxin hydrogenase activity
E	0015948	biological_process	methanogenesis
E	0016491	molecular_function	oxidoreductase activity
E	0019386	biological_process	methanogenesis, from carbon dioxide
E	0030268	molecular_function	methylenetetrahydromethanopterin dehydrogenase activity
F	0006730	biological_process	one-carbon metabolic process
F	0008901	molecular_function	ferredoxin hydrogenase activity
F	0015948	biological_process	methanogenesis
F	0016491	molecular_function	oxidoreductase activity
F	0019386	biological_process	methanogenesis, from carbon dioxide
F	0030268	molecular_function	methylenetetrahydromethanopterin dehydrogenase activity
G	0006730	biological_process	one-carbon metabolic process
G	0008901	molecular_function	ferredoxin hydrogenase activity
G	0015948	biological_process	methanogenesis
G	0016491	molecular_function	oxidoreductase activity
G	0019386	biological_process	methanogenesis, from carbon dioxide
G	0030268	molecular_function	methylenetetrahydromethanopterin dehydrogenase activity
H	0006730	biological_process	one-carbon metabolic process
H	0008901	molecular_function	ferredoxin hydrogenase activity
H	0015948	biological_process	methanogenesis
H	0016491	molecular_function	oxidoreductase activity
H	0019386	biological_process	methanogenesis, from carbon dioxide
H	0030268	molecular_function	methylenetetrahydromethanopterin dehydrogenase activity
I	0006730	biological_process	one-carbon metabolic process
I	0008901	molecular_function	ferredoxin hydrogenase activity
I	0015948	biological_process	methanogenesis
I	0016491	molecular_function	oxidoreductase activity
I	0019386	biological_process	methanogenesis, from carbon dioxide
I	0030268	molecular_function	methylenetetrahydromethanopterin dehydrogenase activity
J	0006730	biological_process	one-carbon metabolic process
J	0008901	molecular_function	ferredoxin hydrogenase activity
J	0015948	biological_process	methanogenesis
J	0016491	molecular_function	oxidoreductase activity
J	0019386	biological_process	methanogenesis, from carbon dioxide
J	0030268	molecular_function	methylenetetrahydromethanopterin dehydrogenase activity
K	0006730	biological_process	one-carbon metabolic process
K	0008901	molecular_function	ferredoxin hydrogenase activity
K	0015948	biological_process	methanogenesis
K	0016491	molecular_function	oxidoreductase activity
K	0019386	biological_process	methanogenesis, from carbon dioxide
K	0030268	molecular_function	methylenetetrahydromethanopterin dehydrogenase activity
L	0006730	biological_process	one-carbon metabolic process
L	0008901	molecular_function	ferredoxin hydrogenase activity
L	0015948	biological_process	methanogenesis
L	0016491	molecular_function	oxidoreductase activity
L	0019386	biological_process	methanogenesis, from carbon dioxide
L	0030268	molecular_function	methylenetetrahydromethanopterin dehydrogenase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG A 6001

Chain	Residue
A	GLU175
A	HOH8346
A	HOH9008
A	HOH9010
A	HOH9011
A	HOH9013
A	HOH9014

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 6002

Chain	Residue
A	HOH9089
A	HOH9090
L	HOH8065
A	HOH9087
A	HOH9088

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 6005

Chain	Residue
B	HOH8542
B	HOH9015
B	HOH9017
B	HOH9018
B	HOH9019

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 6006

Chain	Residue
B	HOH8080
B	HOH9092
B	HOH9095
B	HOH9096
C	HOH8123
C	HOH8441

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG G 6008

Chain	Residue
G	HOH9020
G	HOH9022
G	HOH9023
G	HOH9025

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG G 6009

Chain	Residue
G	HOH8113
G	HOH8333
G	HOH8341
G	HOH9097
G	HOH9099
G	HOH9100

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG H 6011

Chain	Residue
H	HOH8024
H	HOH8490
H	HOH9026
I	HOH8157
I	HOH8241
I	HOH8424

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG H 6012

Chain	Residue
H	HOH8334
H	HOH8478
H	HOH8537
H	HOH8539
H	HOH9104
H	HOH9105

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	336
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---