Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1TZO

Crystal Structure of the Anthrax Toxin Protective Antigen Heptameric Prepore

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0051260	biological_process	protein homooligomerization
B	0005576	cellular_component	extracellular region
B	0051260	biological_process	protein homooligomerization
C	0005576	cellular_component	extracellular region
C	0051260	biological_process	protein homooligomerization
D	0005576	cellular_component	extracellular region
D	0051260	biological_process	protein homooligomerization
E	0005576	cellular_component	extracellular region
E	0051260	biological_process	protein homooligomerization
F	0005576	cellular_component	extracellular region
F	0051260	biological_process	protein homooligomerization
G	0005576	cellular_component	extracellular region
G	0051260	biological_process	protein homooligomerization
H	0005576	cellular_component	extracellular region
H	0051260	biological_process	protein homooligomerization
I	0005576	cellular_component	extracellular region
I	0051260	biological_process	protein homooligomerization
J	0005576	cellular_component	extracellular region
J	0051260	biological_process	protein homooligomerization
K	0005576	cellular_component	extracellular region
K	0051260	biological_process	protein homooligomerization
L	0005576	cellular_component	extracellular region
L	0051260	biological_process	protein homooligomerization
M	0005576	cellular_component	extracellular region
M	0051260	biological_process	protein homooligomerization
O	0005576	cellular_component	extracellular region
O	0051260	biological_process	protein homooligomerization

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 736

Chain	Residue
A	ASP177
A	ASP179
A	ASP181
A	ILE183
A	GLU188

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 737

Chain	Residue
A	LYS225
A	ASP235
A	ASP179
A	ASP181
A	GLU188
A	SER222

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 736

Chain	Residue
B	ASP177
B	ASP179
B	ASP181
B	ILE183
B	GLU188

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 737

Chain	Residue
B	ASP179
B	ASP181
B	GLU188
B	SER222
B	LYS225
B	ASP235

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA C 736

Chain	Residue
C	ASP177
C	ASP179
C	ASP181
C	ILE183
C	GLU188

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 737

Chain	Residue
C	ASP179
C	ASP181
C	GLU188
C	SER222
C	LYS225
C	ASP235

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA D 736

Chain	Residue
D	ASP177
D	ASP179
D	ASP181
D	ILE183
D	GLU188

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 737

Chain	Residue
D	ASP179
D	ASP181
D	GLU188
D	SER222
D	LYS225
D	ASP235

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA E 736

Chain	Residue
E	ASP177
E	ASP179
E	ASP181
E	ILE183
E	GLU188

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 737

Chain	Residue
E	ASP179
E	ASP181
E	GLU188
E	SER222
E	LYS225
E	ASP235

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA F 736

Chain	Residue
F	ASP177
F	ASP179
F	ASP181
F	ILE183
F	GLU188

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA F 737

Chain	Residue
F	ASP179
F	ASP181
F	GLU188
F	SER222
F	LYS225
F	ASP235

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA G 736

Chain	Residue
G	ASP177
G	ASP179
G	ASP181
G	ILE183
G	GLU188

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA G 737

Chain	Residue
G	ASP179
G	ASP181
G	GLU188
G	SER222
G	LYS225
G	ASP235

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA H 736

Chain	Residue
H	ASP177
H	ASP179
H	ASP181
H	ILE183
H	GLU188

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA H 737

Chain	Residue
H	ASP179
H	ASP181
H	GLU188
H	SER222
H	LYS225
H	ASP235

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA I 736

Chain	Residue
I	ASP177
I	ASP179
I	ASP181
I	ILE183
I	GLU188

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA I 737

Chain	Residue
I	ASP179
I	ASP181
I	GLU188
I	SER222
I	LYS225
I	ASP235

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA J 736

Chain	Residue
J	ASP177
J	ASP179
J	ASP181
J	ILE183
J	GLU188

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA J 737

Chain	Residue
J	ASP179
J	ASP181
J	GLU188
J	SER222
J	LYS225
J	ASP235

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA K 736

Chain	Residue
K	ASP177
K	ASP179
K	ASP181
K	ILE183
K	GLU188

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA K 737

Chain	Residue
K	ASP179
K	ASP181
K	GLU188
K	SER222
K	LYS225
K	ASP235

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA L 736

Chain	Residue
L	ASP177
L	ASP179
L	ASP181
L	ILE183
L	GLU188

site_id	CC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA L 737

Chain	Residue
L	ASP179
L	ASP181
L	GLU188
L	SER222
L	LYS225
L	ASP235

site_id	CC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA M 736

Chain	Residue
M	ASP177
M	ASP179
M	ASP181
M	ILE183
M	GLU188

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA M 737

Chain	Residue
M	ASP179
M	ASP181
M	GLU188
M	SER222
M	LYS225
M	ASP235

site_id	CC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA O 736

Chain	Residue
O	ASP177
O	ASP179
O	ASP181
O	ILE183
O	GLU188

site_id	DC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA O 737

Chain	Residue
O	ASP179
O	ASP181
O	GLU188
O	SER222
O	LYS225
O	ASP235

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	280
Details	TRANSMEM: Beta stranded => ECO:0000269\|PubMed:25778700, ECO:0000269\|PubMed:32047164, ECO:0007744\|PDB:3J9C, ECO:0007744\|PDB:6PSN, ECO:0007744\|PDB:6UZB, ECO:0007744\|PDB:6UZD, ECO:0007744\|PDB:6UZE

Chain	Residue	Details
A	GLU302-PHE313
E	ILE316-SER325
F	GLU302-PHE313
F	ILE316-SER325
G	GLU302-PHE313
G	ILE316-SER325
H	GLU302-PHE313
H	ILE316-SER325
I	GLU302-PHE313
I	ILE316-SER325
J	GLU302-PHE313
A	ILE316-SER325
J	ILE316-SER325
K	GLU302-PHE313
K	ILE316-SER325
L	GLU302-PHE313
L	ILE316-SER325
M	GLU302-PHE313
M	ILE316-SER325
O	GLU302-PHE313
O	ILE316-SER325
B	GLU302-PHE313
B	ILE316-SER325
C	GLU302-PHE313
C	ILE316-SER325
D	GLU302-PHE313
D	ILE316-SER325
E	GLU302-PHE313

site_id	SWS_FT_FI2
Number of Residues	42
Details	BINDING: BINDING => ECO:0000269\|PubMed:15243628, ECO:0000269\|PubMed:15326297, ECO:0000269\|PubMed:21037566, ECO:0000269\|PubMed:25778700, ECO:0000269\|PubMed:32047164, ECO:0000269\|PubMed:9039918, ECO:0007744\|PDB:1ACC, ECO:0007744\|PDB:1T6B, ECO:0007744\|PDB:1TZN, ECO:0007744\|PDB:1TZO, ECO:0007744\|PDB:3J9C, ECO:0007744\|PDB:3KWV, ECO:0007744\|PDB:6PSN, ECO:0007744\|PDB:6UZB, ECO:0007744\|PDB:6UZD, ECO:0007744\|PDB:6UZE

Chain	Residue	Details
A	ASP177
D	ASP177
D	ASP181
D	ILE183
E	ASP177
E	ASP181
E	ILE183
F	ASP177
F	ASP181
F	ILE183
G	ASP177
A	ASP181
G	ASP181
G	ILE183
H	ASP177
H	ASP181
H	ILE183
I	ASP177
I	ASP181
I	ILE183
J	ASP177
J	ASP181
A	ILE183
J	ILE183
K	ASP177
K	ASP181
K	ILE183
L	ASP177
L	ASP181
L	ILE183
M	ASP177
M	ASP181
M	ILE183
B	ASP177
O	ASP177
O	ASP181
O	ILE183
B	ASP181
B	ILE183
C	ASP177
C	ASP181
C	ILE183

site_id	SWS_FT_FI3
Number of Residues	14
Details	BINDING: BINDING => ECO:0000269\|PubMed:15243628, ECO:0000269\|PubMed:15326297, ECO:0000269\|PubMed:21037566, ECO:0000269\|PubMed:25778700, ECO:0000269\|PubMed:32047164, ECO:0000269\|PubMed:9039918, ECO:0007744\|PDB:1ACC, ECO:0007744\|PDB:1T6B, ECO:0007744\|PDB:1TZO, ECO:0007744\|PDB:3J9C, ECO:0007744\|PDB:3KWV, ECO:0007744\|PDB:6PSN, ECO:0007744\|PDB:6UZB, ECO:0007744\|PDB:6UZD, ECO:0007744\|PDB:6UZE

Chain	Residue	Details
A	ASP179
J	ASP179
K	ASP179
L	ASP179
M	ASP179
O	ASP179
B	ASP179
C	ASP179
D	ASP179
E	ASP179
F	ASP179
G	ASP179
H	ASP179
I	ASP179

site_id	SWS_FT_FI4
Number of Residues	14
Details	BINDING: BINDING => ECO:0000269\|PubMed:15326297, ECO:0000269\|PubMed:21037566, ECO:0000269\|PubMed:25778700, ECO:0000269\|PubMed:32047164, ECO:0007744\|PDB:1ACC, ECO:0007744\|PDB:1TZN, ECO:0007744\|PDB:1TZO, ECO:0007744\|PDB:3J9C, ECO:0007744\|PDB:3KWV, ECO:0007744\|PDB:6PSN, ECO:0007744\|PDB:6UZB, ECO:0007744\|PDB:6UZD, ECO:0007744\|PDB:6UZE

Chain	Residue	Details
A	GLU188
J	GLU188
K	GLU188
L	GLU188
M	GLU188
O	GLU188
B	GLU188
C	GLU188
D	GLU188
E	GLU188
F	GLU188
G	GLU188
H	GLU188
I	GLU188

site_id	SWS_FT_FI5
Number of Residues	28
Details	BINDING: BINDING => ECO:0000269\|PubMed:15243628, ECO:0000269\|PubMed:15326297, ECO:0000269\|PubMed:21037566, ECO:0000269\|PubMed:25778700, ECO:0000269\|PubMed:32047164, ECO:0007744\|PDB:1ACC, ECO:0007744\|PDB:1T6B, ECO:0007744\|PDB:1TZN, ECO:0007744\|PDB:1TZO, ECO:0007744\|PDB:3J9C, ECO:0007744\|PDB:3KWV, ECO:0007744\|PDB:6PSN, ECO:0007744\|PDB:6UZB, ECO:0007744\|PDB:6UZD, ECO:0007744\|PDB:6UZE

Chain	Residue	Details
A	SER222
E	LYS225
F	SER222
F	LYS225
G	SER222
G	LYS225
H	SER222
H	LYS225
I	SER222
I	LYS225
J	SER222
A	LYS225
J	LYS225
K	SER222
K	LYS225
L	SER222
L	LYS225
M	SER222
M	LYS225
O	SER222
O	LYS225
B	SER222
B	LYS225
C	SER222
C	LYS225
D	SER222
D	LYS225
E	SER222

site_id	SWS_FT_FI6
Number of Residues	14
Details	BINDING: BINDING => ECO:0000269\|PubMed:15243628, ECO:0000269\|PubMed:15326297, ECO:0000269\|PubMed:21037566, ECO:0000269\|PubMed:32047164, ECO:0007744\|PDB:1ACC, ECO:0007744\|PDB:1T6B, ECO:0007744\|PDB:1TZN, ECO:0007744\|PDB:1TZO, ECO:0007744\|PDB:3KWV, ECO:0007744\|PDB:6PSN, ECO:0007744\|PDB:6UZB, ECO:0007744\|PDB:6UZD, ECO:0007744\|PDB:6UZE

Chain	Residue	Details
A	ASP235
J	ASP235
K	ASP235
L	ASP235
M	ASP235
O	ASP235
B	ASP235
C	ASP235
D	ASP235
E	ASP235
F	ASP235
G	ASP235
H	ASP235
I	ASP235

site_id	SWS_FT_FI7
Number of Residues	56
Details	SITE: Alpha-clamp => ECO:0000269\|PubMed:21037566

Chain	Residue	Details
A	ARG178
C	LEU187
C	PHE236
C	PHE464
D	ARG178
D	LEU187
D	PHE236
D	PHE464
E	ARG178
E	LEU187
E	PHE236
A	LEU187
E	PHE464
F	ARG178
F	LEU187
F	PHE236
F	PHE464
G	ARG178
G	LEU187
G	PHE236
G	PHE464
H	ARG178
A	PHE236
H	LEU187
H	PHE236
H	PHE464
I	ARG178
I	LEU187
I	PHE236
I	PHE464
J	ARG178
J	LEU187
J	PHE236
A	PHE464
J	PHE464
K	ARG178
K	LEU187
K	PHE236
K	PHE464
L	ARG178
L	LEU187
L	PHE236
L	PHE464
M	ARG178
B	ARG178
M	LEU187
M	PHE236
M	PHE464
O	ARG178
O	LEU187
O	PHE236
O	PHE464
B	LEU187
B	PHE236
B	PHE464
C	ARG178

site_id	SWS_FT_FI8
Number of Residues	14
Details	SITE: Cleavage; by chymotrypsin; required for translocation of LF and EF => ECO:0000269\|PubMed:7961869

Chain	Residue	Details
A	PHE314
J	PHE314
K	PHE314
L	PHE314
M	PHE314
O	PHE314
B	PHE314
C	PHE314
D	PHE314
E	PHE314
F	PHE314
G	PHE314
H	PHE314
I	PHE314

site_id	SWS_FT_FI9
Number of Residues	14
Details	SITE: Phi-clamp => ECO:0000269\|PubMed:16051798, ECO:0000269\|PubMed:25778700

Chain	Residue	Details
A	PHE427
J	PHE427
K	PHE427
L	PHE427
M	PHE427
O	PHE427
B	PHE427
C	PHE427
D	PHE427
E	PHE427
F	PHE427
G	PHE427
H	PHE427
I	PHE427

site_id	SWS_FT_FI10
Number of Residues	14
Details	SITE: Essential for binding to cell receptor => ECO:0000269\|PubMed:12771151

Chain	Residue	Details
A	ASP683
J	ASP683
K	ASP683
L	ASP683
M	ASP683
O	ASP683
B	ASP683
C	ASP683
D	ASP683
E	ASP683
F	ASP683
G	ASP683
H	ASP683
I	ASP683

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)