1TYH

Crystal Structure of Transcriptional Activator tenA from Bacillus subtilis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0006772	biological_process	thiamine metabolic process
A	0006790	biological_process	sulfur compound metabolic process
A	0009228	biological_process	thiamine biosynthetic process
A	0009229	biological_process	thiamine diphosphate biosynthetic process
A	0016787	molecular_function	hydrolase activity
A	0044281	biological_process	small molecule metabolic process
A	0050334	molecular_function	thiaminase activity
A	0072527	biological_process	pyrimidine-containing compound metabolic process
A	1901615	biological_process	organic hydroxy compound metabolic process
B	0005829	cellular_component	cytosol
B	0006772	biological_process	thiamine metabolic process
B	0006790	biological_process	sulfur compound metabolic process
B	0009228	biological_process	thiamine biosynthetic process
B	0009229	biological_process	thiamine diphosphate biosynthetic process
B	0016787	molecular_function	hydrolase activity
B	0044281	biological_process	small molecule metabolic process
B	0050334	molecular_function	thiaminase activity
B	0072527	biological_process	pyrimidine-containing compound metabolic process
B	1901615	biological_process	organic hydroxy compound metabolic process
D	0005829	cellular_component	cytosol
D	0006772	biological_process	thiamine metabolic process
D	0006790	biological_process	sulfur compound metabolic process
D	0009228	biological_process	thiamine biosynthetic process
D	0009229	biological_process	thiamine diphosphate biosynthetic process
D	0016787	molecular_function	hydrolase activity
D	0044281	biological_process	small molecule metabolic process
D	0050334	molecular_function	thiaminase activity
D	0072527	biological_process	pyrimidine-containing compound metabolic process
D	1901615	biological_process	organic hydroxy compound metabolic process
E	0005829	cellular_component	cytosol
E	0006772	biological_process	thiamine metabolic process
E	0006790	biological_process	sulfur compound metabolic process
E	0009228	biological_process	thiamine biosynthetic process
E	0009229	biological_process	thiamine diphosphate biosynthetic process
E	0016787	molecular_function	hydrolase activity
E	0044281	biological_process	small molecule metabolic process
E	0050334	molecular_function	thiaminase activity
E	0072527	biological_process	pyrimidine-containing compound metabolic process
E	1901615	biological_process	organic hydroxy compound metabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Nucleophile => ECO:0000303|PubMed:18054064

Chain	Residue	Details
A	CYS135
B	CYS135
D	CYS135
E	CYS135

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site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Proton donor => ECO:0000303|PubMed:18054064

Chain	Residue	Details
A	GLU205
B	GLU205
D	GLU205
E	GLU205

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site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:15709744, ECO:0000269|Ref.5

Chain	Residue	Details
A	ASP44
E	ASP44
E	TYR139
E	TYR163
A	TYR139
A	TYR163
B	ASP44
B	TYR139
B	TYR163
D	ASP44
D	TYR139
D	TYR163

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site_id	SWS_FT_FI4
Number of Residues	4
Details	SITE: Increases nucleophilicity of active site Cys => ECO:0000303|PubMed:18054064

Chain	Residue	Details
A	TYR47
B	TYR47
D	TYR47
E	TYR47

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