Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1TVB

Crystal structure of Melanoma Antigen gp100(209-217) Bound to Human Class I MHC HLA-A2

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000139	cellular_component	Golgi membrane
B	0001913	biological_process	T cell mediated cytotoxicity
B	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
B	0002237	biological_process	response to molecule of bacterial origin
B	0002376	biological_process	immune system process
B	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
B	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
B	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
B	0002726	biological_process	positive regulation of T cell cytokine production
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005765	cellular_component	lysosomal membrane
B	0005783	cellular_component	endoplasmic reticulum
B	0005788	cellular_component	endoplasmic reticulum lumen
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005925	cellular_component	focal adhesion
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0007608	biological_process	sensory perception of smell
B	0007611	biological_process	learning or memory
B	0009897	cellular_component	external side of plasma membrane
B	0009986	cellular_component	cell surface
B	0010038	biological_process	response to metal ion
B	0010977	biological_process	negative regulation of neuron projection development
B	0012507	cellular_component	ER to Golgi transport vesicle membrane
B	0016020	cellular_component	membrane
B	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
B	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
B	0023026	molecular_function	MHC class II protein complex binding
B	0030670	cellular_component	phagocytic vesicle membrane
B	0031901	cellular_component	early endosome membrane
B	0031902	cellular_component	late endosome membrane
B	0031905	cellular_component	early endosome lumen
B	0033077	biological_process	T cell differentiation in thymus
B	0033572	biological_process	transferrin transport
B	0034756	biological_process	regulation of iron ion transport
B	0034757	biological_process	negative regulation of iron ion transport
B	0035580	cellular_component	specific granule lumen
B	0042026	biological_process	protein refolding
B	0042605	molecular_function	peptide antigen binding
B	0042612	cellular_component	MHC class I protein complex
B	0042613	cellular_component	MHC class II protein complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042824	cellular_component	MHC class I peptide loading complex
B	0045646	biological_process	regulation of erythrocyte differentiation
B	0048260	biological_process	positive regulation of receptor-mediated endocytosis
B	0048261	biological_process	negative regulation of receptor-mediated endocytosis
B	0050680	biological_process	negative regulation of epithelial cell proliferation
B	0050768	biological_process	negative regulation of neurogenesis
B	0050778	biological_process	positive regulation of immune response
B	0050870	biological_process	positive regulation of T cell activation
B	0051289	biological_process	protein homotetramerization
B	0055038	cellular_component	recycling endosome membrane
B	0060586	biological_process	multicellular organismal-level iron ion homeostasis
B	0070062	cellular_component	extracellular exosome
B	0071281	biological_process	cellular response to iron ion
B	0071283	biological_process	cellular response to iron(III) ion
B	0071316	biological_process	cellular response to nicotine
B	1904724	cellular_component	tertiary granule lumen
B	1990000	biological_process	amyloid fibril formation
B	1990712	cellular_component	HFE-transferrin receptor complex
B	2000774	biological_process	positive regulation of cellular senescence
B	2000978	biological_process	negative regulation of forebrain neuron differentiation
E	0000139	cellular_component	Golgi membrane
E	0001913	biological_process	T cell mediated cytotoxicity
E	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
E	0002237	biological_process	response to molecule of bacterial origin
E	0002376	biological_process	immune system process
E	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
E	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
E	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
E	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
E	0002726	biological_process	positive regulation of T cell cytokine production
E	0005198	molecular_function	structural molecule activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005765	cellular_component	lysosomal membrane
E	0005783	cellular_component	endoplasmic reticulum
E	0005788	cellular_component	endoplasmic reticulum lumen
E	0005794	cellular_component	Golgi apparatus
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0005925	cellular_component	focal adhesion
E	0006826	biological_process	iron ion transport
E	0006879	biological_process	intracellular iron ion homeostasis
E	0006955	biological_process	immune response
E	0007608	biological_process	sensory perception of smell
E	0007611	biological_process	learning or memory
E	0009897	cellular_component	external side of plasma membrane
E	0009986	cellular_component	cell surface
E	0010038	biological_process	response to metal ion
E	0010977	biological_process	negative regulation of neuron projection development
E	0012507	cellular_component	ER to Golgi transport vesicle membrane
E	0016020	cellular_component	membrane
E	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
E	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
E	0023026	molecular_function	MHC class II protein complex binding
E	0030670	cellular_component	phagocytic vesicle membrane
E	0031901	cellular_component	early endosome membrane
E	0031902	cellular_component	late endosome membrane
E	0031905	cellular_component	early endosome lumen
E	0033077	biological_process	T cell differentiation in thymus
E	0033572	biological_process	transferrin transport
E	0034756	biological_process	regulation of iron ion transport
E	0034757	biological_process	negative regulation of iron ion transport
E	0035580	cellular_component	specific granule lumen
E	0042026	biological_process	protein refolding
E	0042605	molecular_function	peptide antigen binding
E	0042612	cellular_component	MHC class I protein complex
E	0042613	cellular_component	MHC class II protein complex
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0042824	cellular_component	MHC class I peptide loading complex
E	0045646	biological_process	regulation of erythrocyte differentiation
E	0048260	biological_process	positive regulation of receptor-mediated endocytosis
E	0048261	biological_process	negative regulation of receptor-mediated endocytosis
E	0050680	biological_process	negative regulation of epithelial cell proliferation
E	0050768	biological_process	negative regulation of neurogenesis
E	0050778	biological_process	positive regulation of immune response
E	0050870	biological_process	positive regulation of T cell activation
E	0051289	biological_process	protein homotetramerization
E	0055038	cellular_component	recycling endosome membrane
E	0060586	biological_process	multicellular organismal-level iron ion homeostasis
E	0070062	cellular_component	extracellular exosome
E	0071281	biological_process	cellular response to iron ion
E	0071283	biological_process	cellular response to iron(III) ion
E	0071316	biological_process	cellular response to nicotine
E	1904724	cellular_component	tertiary granule lumen
E	1990000	biological_process	amyloid fibril formation
E	1990712	cellular_component	HFE-transferrin receptor complex
E	2000774	biological_process	positive regulation of cellular senescence
E	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1001

Chain	Residue
A	VAL76
A	TYR84
A	LYS146
A	HOH1143
B	PRO14
B	HOH1068
C	SER8
C	VAL9

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1002

Chain	Residue
A	PHE8
A	ASP29
A	ASP30
A	HOH1036
A	HOH1097
B	TYR63
B	GOL1008
A	ARG6

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 1004

Chain	Residue
A	TYR84
A	ASN86
A	HIS191
A	HIS192
A	ALA193
A	HOH1019
A	HOH1059
A	HOH1117
A	HOH1285

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1005

Chain	Residue
A	TYR85
A	GLN87
A	TYR118
A	ASP119
A	HOH1070
A	HOH1170
B	MET0

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1013

Chain	Residue
A	LEU206
A	SER207
A	GLN242
A	HOH1160
B	ARG12
B	HIS13
B	PRO14
B	GOL1019

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL B 1006

Chain	Residue
B	TYR10
B	SER11
B	PRO14
B	ALA15
B	TRP95
B	ARG97
B	GOL1019
B	HOH1056
B	HOH1069
B	HOH1111

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B 1008

Chain	Residue
A	PHE241
A	GOL1002
B	TYR26
B	TYR63

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 1012

Chain	Residue
B	GLY43
B	ARG45
B	ARG81
D	SER38
D	GLN43

site_id	AC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL B 1019

Chain	Residue
A	LEU206
A	ARG234
A	GLN242
A	GOL1013
B	TYR10
B	SER11
B	HIS13
B	PRO14
B	GOL1006
B	HOH1085

site_id	BC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL D 1003

Chain	Residue
D	ARG6
D	PHE8
D	TYR27
D	ASP29
D	ASP30
D	GOL1017
D	HOH1098
D	HOH1229
E	TYR63

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL D 1007

Chain	Residue
D	GLN218
D	THR258
D	HIS260
D	THR271
D	ARG273

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL D 1010

Chain	Residue
D	GLY252
D	GLN253
D	GLN255
D	ARG256

site_id	BC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL D 1011

Chain	Residue
D	TYR59
D	GLY62
D	GLU63
D	LYS66
D	HOH1094
D	HOH1271
D	HOH1276
D	HOH1321
F	ILE1

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL D 1014

Chain	Residue
D	HOH1275
D	HOH1286
D	PRO20
D	ARG75
D	HOH1029

site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL D 1015

Chain	Residue
D	TYR84
D	LYS146
D	HIS188
D	THR190
D	TRP204
D	HOH1093
E	MET99

site_id	BC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL D 1017

Chain	Residue
D	THR233
D	ARG234
D	PRO235
D	PHE241
D	GOL1003
D	GOL1020
D	HOH1302
E	TYR26
E	HOH1148

site_id	BC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL D 1018

Chain	Residue
D	TYR85
D	GLN87
D	TYR118
D	ASP119
D	HOH1058
D	HOH1216
E	MET0

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL D 1020

Chain	Residue
D	GLU232
D	THR233
D	GOL1017
D	HOH1070
E	TYR26

site_id	CC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL D 1021

Chain	Residue
D	LYS186
D	LEU206
D	SER207
D	GLN242
D	HOH1131
E	ARG12
E	HIS13
E	PRO14
E	GOL1009
E	HOH1055

site_id	CC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL D 1022

Chain	Residue
A	PRO269
D	GLU154
D	ARG157
D	HOH1046
D	HOH1077
D	HOH1099
D	HOH1270
D	HOH1303

site_id	CC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL E 1009

Chain	Residue
D	ARG234
D	GLN242
D	GOL1021
E	TYR10
E	SER11
E	ARG12
E	HIS13
E	PRO14
E	HOH1023
E	HOH1122

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL E 1016

Chain	Residue
E	GLY43
E	HOH1086
E	HOH1124

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH

Chain	Residue	Details
B	TYR78-HIS84
A	TYR257-HIS263

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269\|PubMed:7554280

Chain	Residue	Details
B	GLN2
D	THR143
D	LYS146
D	TYR171
E	GLN2
A	TYR84
A	THR143
A	LYS146
A	TYR171
D	TYR7
D	THR73
D	TYR84

site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269\|PubMed:7918443

Chain	Residue	Details
B	ILE1
E	ILE1
D	TYR116
D	TYR159

site_id	SWS_FT_FI3
Number of Residues	12
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269\|PubMed:7918443

Chain	Residue	Details
B	LYS19
E	LYS58
E	LYS91
E	LYS94
B	LYS41
B	LYS48
B	LYS58
B	LYS91
B	LYS94
E	LYS19
E	LYS41
E	LYS48

site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19159218

Chain	Residue	Details
A	ASN86
D	ASN86

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)