1TV9
HUMAN DNA POLYMERASE BETA COMPLEXED WITH NICKED DNA CONTAINING A MISMATCHED TEMPLATE ADENINE AND INCOMING CYTIDINE
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001701 | biological_process | in utero embryonic development |
A | 0003677 | molecular_function | DNA binding |
A | 0003684 | molecular_function | damaged DNA binding |
A | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
A | 0003906 | molecular_function | DNA-(apurinic or apyrimidinic site) endonuclease activity |
A | 0005515 | molecular_function | protein binding |
A | 0005634 | cellular_component | nucleus |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0005874 | cellular_component | microtubule |
A | 0005876 | cellular_component | spindle microtubule |
A | 0006259 | biological_process | DNA metabolic process |
A | 0006260 | biological_process | DNA replication |
A | 0006261 | biological_process | DNA-templated DNA replication |
A | 0006281 | biological_process | DNA repair |
A | 0006284 | biological_process | base-excision repair |
A | 0006287 | biological_process | base-excision repair, gap-filling |
A | 0006290 | biological_process | pyrimidine dimer repair |
A | 0006297 | biological_process | nucleotide-excision repair, DNA gap filling |
A | 0006303 | biological_process | double-strand break repair via nonhomologous end joining |
A | 0006915 | biological_process | apoptotic process |
A | 0006954 | biological_process | inflammatory response |
A | 0006974 | biological_process | DNA damage response |
A | 0007435 | biological_process | salivary gland morphogenesis |
A | 0008017 | molecular_function | microtubule binding |
A | 0008630 | biological_process | intrinsic apoptotic signaling pathway in response to DNA damage |
A | 0010332 | biological_process | response to gamma radiation |
A | 0016445 | biological_process | somatic diversification of immunoglobulins |
A | 0016446 | biological_process | somatic hypermutation of immunoglobulin genes |
A | 0016779 | molecular_function | nucleotidyltransferase activity |
A | 0016829 | molecular_function | lyase activity |
A | 0019899 | molecular_function | enzyme binding |
A | 0032991 | cellular_component | protein-containing complex |
A | 0034061 | molecular_function | DNA polymerase activity |
A | 0045471 | biological_process | response to ethanol |
A | 0046872 | molecular_function | metal ion binding |
A | 0048535 | biological_process | lymph node development |
A | 0048536 | biological_process | spleen development |
A | 0048872 | biological_process | homeostasis of number of cells |
A | 0051402 | biological_process | neuron apoptotic process |
A | 0051575 | molecular_function | 5'-deoxyribose-5-phosphate lyase activity |
A | 0055093 | biological_process | response to hyperoxia |
A | 0071707 | biological_process | immunoglobulin heavy chain V-D-J recombination |
A | 0071897 | biological_process | DNA biosynthetic process |
A | 0140078 | molecular_function | class I DNA-(apurinic or apyrimidinic site) endonuclease activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG A 781 |
Chain | Residue |
A | SER30 |
A | SER171 |
A | HOH847 |
A | HOH901 |
A | HOH972 |
A | HOH996 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA A 784 |
Chain | Residue |
A | HOH822 |
P | DG9 |
P | HOH19 |
A | THR101 |
A | VAL103 |
A | ILE106 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA A 785 |
Chain | Residue |
A | LYS60 |
A | LEU62 |
A | VAL65 |
A | HOH821 |
A | HOH913 |
D | DC3 |
site_id | AC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MG P 786 |
Chain | Residue |
A | HOH1348 |
A | HOH1349 |
A | HOH1350 |
P | DC10 |
P | DC11 |
P | HOH788 |
P | HOH791 |
site_id | AC5 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE PO4 A 792 |
Chain | Residue |
A | GLY179 |
A | SER180 |
A | SER188 |
A | GLY189 |
A | ASP190 |
A | HOH933 |
A | HOH970 |
A | HOH1234 |
P | HOH791 |
Functional Information from PROSITE/UniProt
site_id | PS00522 |
Number of Residues | 20 |
Details | DNA_POLYMERASE_X DNA polymerase family X signature. GSFrRGaesSgDMDVLLthP |
Chain | Residue | Details |
A | GLY179-PRO198 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity => ECO:0000269|PubMed:9572863 |
Chain | Residue | Details |
A | ILE73 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12517346, ECO:0000269|PubMed:8841120, ECO:0000269|PubMed:9287163, ECO:0007744|PDB:1BPX, ECO:0007744|PDB:1BPZ, ECO:0007744|PDB:1MQ3, ECO:0007744|PDB:1ZQO, ECO:0007744|PDB:1ZQQ |
Chain | Residue | Details |
A | LYS61 | |
A | PRO63 | |
A | GLY66 | |
A | ARG102 | |
A | SER104 | |
A | GLY107 |
site_id | SWS_FT_FI3 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:8841119, ECO:0007744|PDB:8ICW, ECO:0007744|PDB:8ICX, ECO:0007744|PDB:8ICY |
Chain | Residue | Details |
A | ILE150 | |
A | PHE181 | |
A | ASP190 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:8841119, ECO:0007744|PDB:8ICX |
Chain | Residue | Details |
A | GLY184 |
site_id | SWS_FT_FI5 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:9287163, ECO:0007744|PDB:1BPY |
Chain | Residue | Details |
A | MET191 | |
A | VAL193 | |
A | ILE257 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q8K409 |
Chain | Residue | Details |
A | ILE73 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | MOD_RES: Omega-N-methylarginine; by PRMT6 => ECO:0000269|PubMed:16600869 |
Chain | Residue | Details |
A | LYS84 | |
A | GLU153 |
site_id | SWS_FT_FI8 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19713937, ECO:0000269|PubMed:21362556 |
Chain | Residue | Details |
A | ALA42 | |
A | LEU62 | |
A | LEU82 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1jms |
Chain | Residue | Details |
A | ASP256 |