1TPZ
Crystal Structure of IIGP1: a paradigm for interferon inducible p47 resistance GTPases
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000045 | biological_process | autophagosome assembly |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0002376 | biological_process | immune system process |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0009617 | biological_process | response to bacterium |
| A | 0010506 | biological_process | regulation of autophagy |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019003 | molecular_function | GDP binding |
| A | 0019221 | biological_process | cytokine-mediated signaling pathway |
| A | 0020005 | cellular_component | symbiont-containing vacuole membrane |
| A | 0031965 | cellular_component | nuclear membrane |
| A | 0032580 | cellular_component | Golgi cisterna membrane |
| A | 0035458 | biological_process | cellular response to interferon-beta |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042832 | biological_process | defense response to protozoan |
| A | 0045087 | biological_process | innate immune response |
| A | 0050829 | biological_process | defense response to Gram-negative bacterium |
| B | 0000045 | biological_process | autophagosome assembly |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0002376 | biological_process | immune system process |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0009617 | biological_process | response to bacterium |
| B | 0010506 | biological_process | regulation of autophagy |
| B | 0016020 | cellular_component | membrane |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0019003 | molecular_function | GDP binding |
| B | 0019221 | biological_process | cytokine-mediated signaling pathway |
| B | 0020005 | cellular_component | symbiont-containing vacuole membrane |
| B | 0031965 | cellular_component | nuclear membrane |
| B | 0032580 | cellular_component | Golgi cisterna membrane |
| B | 0035458 | biological_process | cellular response to interferon-beta |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042832 | biological_process | defense response to protozoan |
| B | 0045087 | biological_process | innate immune response |
| B | 0050829 | biological_process | defense response to Gram-negative bacterium |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 1501 |
| Chain | Residue |
| A | SER83 |
| A | GDP1500 |
| A | HOH1709 |
| A | HOH1710 |
| A | HOH1711 |
| A | HOH1712 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 2501 |
| Chain | Residue |
| B | HOH2635 |
| B | HOH2666 |
| B | HOH2693 |
| B | SER83 |
| B | GDP2500 |
| B | HOH2592 |
| site_id | AC3 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE GDP A 1500 |
| Chain | Residue |
| A | GLU77 |
| A | GLY79 |
| A | SER80 |
| A | GLY81 |
| A | LYS82 |
| A | SER83 |
| A | SER84 |
| A | THR102 |
| A | GLY103 |
| A | LYS184 |
| A | ASP186 |
| A | SER187 |
| A | SER231 |
| A | ASN232 |
| A | LYS233 |
| A | MG1501 |
| A | HOH1634 |
| A | HOH1636 |
| A | HOH1641 |
| A | HOH1690 |
| A | HOH1699 |
| A | HOH1709 |
| A | HOH1711 |
| A | HOH1712 |
| site_id | AC4 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE GDP B 2500 |
| Chain | Residue |
| B | GLY79 |
| B | SER80 |
| B | GLY81 |
| B | LYS82 |
| B | SER83 |
| B | SER84 |
| B | THR102 |
| B | GLY103 |
| B | LYS184 |
| B | ASP186 |
| B | SER231 |
| B | ASN232 |
| B | LYS233 |
| B | MG2501 |
| B | HOH2528 |
| B | HOH2592 |
| B | HOH2635 |
| B | HOH2660 |
| B | HOH2666 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO B 2000 |
| Chain | Residue |
| B | HIS116 |
| B | ASN118 |
| B | VAL261 |
| B | SER262 |
| B | LEU263 |
| B | LYS274 |
| B | VAL319 |
| B | HOH2705 |
| B | HOH2728 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MPD B 1000 |
| Chain | Residue |
| B | ASN265 |
| B | PHE320 |
| B | GLY321 |
| B | LEU330 |
| B | ALA402 |
| B | ILE409 |
| B | HOH2621 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12732635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25118287","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LV5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LV8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25118287","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LV5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LV8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12732635","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25118287","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LV5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"(Microbial infection) Phosphothreonine; by ROP18","evidences":[{"source":"PubMed","id":"21203588","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
