1TKD
T7 DNA polymerase ternary complex with 8 oxo guanosine and dCMP at the elongation site
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0004527 | molecular_function | exonuclease activity |
| A | 0004529 | molecular_function | DNA exonuclease activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0006260 | biological_process | DNA replication |
| A | 0006261 | biological_process | DNA-templated DNA replication |
| A | 0008152 | biological_process | metabolic process |
| A | 0008408 | molecular_function | 3'-5' exonuclease activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0039693 | biological_process | viral DNA genome replication |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0090592 | biological_process | DNA synthesis involved in DNA replication |
| A | 0097681 | biological_process | double-strand break repair via alternative nonhomologous end joining |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0015035 | molecular_function | protein-disulfide reductase activity |
| B | 0015036 | molecular_function | disulfide oxidoreductase activity |
| B | 0030337 | molecular_function | DNA polymerase processivity factor activity |
| B | 0045454 | biological_process | cell redox homeostasis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 901 |
| Chain | Residue |
| A | ASP475 |
| A | ALA476 |
| A | ASP654 |
| A | D3T823 |
| A | MG902 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 902 |
| Chain | Residue |
| A | HOH1372 |
| A | HOH1507 |
| A | ASP475 |
| A | ASP654 |
| A | D3T823 |
| A | MG901 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 903 |
| Chain | Residue |
| A | ASP5 |
| A | HOH1091 |
| A | HOH1093 |
| A | HOH1094 |
| A | HOH1479 |
| A | HOH1480 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 904 |
| Chain | Residue |
| A | LYS226 |
| A | ARG229 |
| A | HOH1022 |
| A | HOH1088 |
| A | HOH1277 |
| A | HOH1609 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 905 |
| Chain | Residue |
| A | LYS184 |
| A | ARG661 |
| A | HOH1075 |
| A | HOH1415 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 906 |
| Chain | Residue |
| A | ASN162 |
| A | ARG255 |
| A | LYS256 |
| A | THR279 |
| A | LYS281 |
| A | HOH1393 |
| site_id | AC7 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE D3T A 823 |
| Chain | Residue |
| A | ARG429 |
| A | ASP475 |
| A | ALA476 |
| A | GLY478 |
| A | LEU479 |
| A | GLU480 |
| A | HIS506 |
| A | ARG518 |
| A | LYS522 |
| A | TYR526 |
| A | ASP654 |
| A | MG901 |
| A | MG902 |
| A | HOH1178 |
| A | HOH1205 |
| A | HOH1608 |
| P | DOC822 |
| T | DA854 |
| T | 8OG855 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE MES A 991 |
| Chain | Residue |
| A | LEU77 |
| A | ASN78 |
| A | ARG79 |
| A | HOH1188 |
| A | HOH1341 |
| B | ILE5 |
| B | HIS6 |
| B | SER11 |
| B | THR14 |
| B | ASP15 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 1PE A 992 |
| Chain | Residue |
| A | ALA10 |
| A | TYR64 |
| A | MET107 |
| A | LEU109 |
| A | LYS136 |
| A | TRP160 |
| A | HOH1405 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Nucleophile |
| Chain | Residue | Details |
| B | GLY33 | |
| B | LYS36 | |
| A | ALA180 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Deprotonates C-terminal active site Cys |
| Chain | Residue | Details |
| B | PHE27 | |
| A | ARG482 | |
| A | CYS660 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Contributes to redox potential value |
| Chain | Residue | Details |
| B | PRO34 | |
| B | CYS35 | |
| A | PHE528 | |
| A | ALA532 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18723842 |
| Chain | Residue | Details |
| B | TYR70 |
