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1TIJ

3D Domain-swapped human cystatin C with amyloid-like intermolecular beta-sheets

Functional Information from GO Data
ChainGOidnamespacecontents
A0001540molecular_functionamyloid-beta binding
A0002020molecular_functionprotease binding
A0004866molecular_functionendopeptidase inhibitor activity
A0004869molecular_functioncysteine-type endopeptidase inhibitor activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005788cellular_componentendoplasmic reticulum lumen
A0005794cellular_componentGolgi apparatus
A0005886cellular_componentplasma membrane
A0006952biological_processdefense response
A0010466biological_processnegative regulation of peptidase activity
A0010711biological_processnegative regulation of collagen catabolic process
A0010716biological_processnegative regulation of extracellular matrix disassembly
A0030414molecular_functionpeptidase inhibitor activity
A0031982cellular_componentvesicle
A0034103biological_processregulation of tissue remodeling
A0042802molecular_functionidentical protein binding
A0045861biological_processnegative regulation of proteolysis
A0060311biological_processnegative regulation of elastin catabolic process
A0060313biological_processnegative regulation of blood vessel remodeling
A0070062cellular_componentextracellular exosome
A0097435biological_processsupramolecular fiber organization
A1904724cellular_componenttertiary granule lumen
A1904813cellular_componentficolin-1-rich granule lumen
B0001540molecular_functionamyloid-beta binding
B0002020molecular_functionprotease binding
B0004866molecular_functionendopeptidase inhibitor activity
B0004869molecular_functioncysteine-type endopeptidase inhibitor activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005788cellular_componentendoplasmic reticulum lumen
B0005794cellular_componentGolgi apparatus
B0005886cellular_componentplasma membrane
B0006952biological_processdefense response
B0010466biological_processnegative regulation of peptidase activity
B0010711biological_processnegative regulation of collagen catabolic process
B0010716biological_processnegative regulation of extracellular matrix disassembly
B0030414molecular_functionpeptidase inhibitor activity
B0031982cellular_componentvesicle
B0034103biological_processregulation of tissue remodeling
B0042802molecular_functionidentical protein binding
B0045861biological_processnegative regulation of proteolysis
B0060311biological_processnegative regulation of elastin catabolic process
B0060313biological_processnegative regulation of blood vessel remodeling
B0070062cellular_componentextracellular exosome
B0097435biological_processsupramolecular fiber organization
B1904724cellular_componenttertiary granule lumen
B1904813cellular_componentficolin-1-rich granule lumen
Functional Information from PROSITE/UniProt
site_idPS00287
Number of Residues14
DetailsCYSTATIN Cysteine proteases inhibitors signature. KQIVAGVNYfLDVE
ChainResidueDetails
ALYS54-GLU67

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Reactive site
ChainResidueDetails
AGLY11
BGLY11

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039
ChainResidueDetails
ASER17
BSER17

218853

PDB entries from 2024-04-24

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