1T9S
Catalytic Domain Of Human Phosphodiesterase 5A in Complex with GMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ZN A 1 |
| Chain | Residue |
| A | MG2 |
| A | HIS617 |
| A | HIS653 |
| A | ASP654 |
| A | ASP764 |
| A | 5GP859 |
| A | HOH1151 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG A 2 |
| Chain | Residue |
| A | 5GP859 |
| A | HOH1151 |
| A | HOH1152 |
| A | HOH1153 |
| A | HOH1154 |
| A | ZN1 |
| A | ASP654 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ZN B 1 |
| Chain | Residue |
| B | MG2 |
| B | HIS617 |
| B | HIS653 |
| B | ASP654 |
| B | ASP764 |
| B | 5GP859 |
| B | HOH1133 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG B 2 |
| Chain | Residue |
| B | ZN1 |
| B | ASP654 |
| B | 5GP859 |
| B | HOH1133 |
| B | HOH1134 |
| B | HOH1135 |
| B | HOH1136 |
| site_id | AC5 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 5GP A 859 |
| Chain | Residue |
| A | ZN1 |
| A | MG2 |
| A | HIS613 |
| A | HIS617 |
| A | ASP654 |
| A | ASP764 |
| A | LEU765 |
| A | GLN817 |
| A | PHE820 |
| A | HOH862 |
| A | HOH866 |
| A | HOH867 |
| A | HOH888 |
| A | HOH904 |
| A | HOH998 |
| A | HOH1151 |
| A | HOH1153 |
| A | HOH1155 |
| site_id | AC6 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 5GP B 859 |
| Chain | Residue |
| B | ZN1 |
| B | MG2 |
| B | HIS613 |
| B | HIS617 |
| B | ASP654 |
| B | ASP764 |
| B | LEU765 |
| B | GLN817 |
| B | PHE820 |
| B | HOH861 |
| B | HOH863 |
| B | HOH877 |
| B | HOH905 |
| B | HOH938 |
| B | HOH958 |
| B | HOH1133 |
| B | HOH1136 |
| B | HOH1137 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHpGvsNqF |
| Chain | Residue | Details |
| A | HIS653-PHE664 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"O76083","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12955149","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12955149","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
