1T8P
Crystal structure of Human erythrocyte 2,3-bisphosphoglycerate mutase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004082 | molecular_function | bisphosphoglycerate mutase activity |
| A | 0004619 | molecular_function | phosphoglycerate mutase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006096 | biological_process | glycolytic process |
| A | 0006753 | biological_process | nucleoside phosphate metabolic process |
| A | 0007585 | biological_process | respiratory gaseous exchange by respiratory system |
| A | 0015671 | biological_process | oxygen transport |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0016868 | molecular_function | intramolecular phosphotransferase activity |
| A | 0033554 | biological_process | cellular response to stress |
| A | 0042832 | biological_process | defense response to protozoan |
| A | 0048821 | biological_process | erythrocyte development |
| A | 0060856 | biological_process | establishment of blood-brain barrier |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0150076 | biological_process | neuroinflammatory response |
| A | 1901136 | biological_process | carbohydrate derivative catabolic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004082 | molecular_function | bisphosphoglycerate mutase activity |
| B | 0004619 | molecular_function | phosphoglycerate mutase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006096 | biological_process | glycolytic process |
| B | 0006753 | biological_process | nucleoside phosphate metabolic process |
| B | 0007585 | biological_process | respiratory gaseous exchange by respiratory system |
| B | 0015671 | biological_process | oxygen transport |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0016868 | molecular_function | intramolecular phosphotransferase activity |
| B | 0033554 | biological_process | cellular response to stress |
| B | 0042832 | biological_process | defense response to protozoan |
| B | 0048821 | biological_process | erythrocyte development |
| B | 0060856 | biological_process | establishment of blood-brain barrier |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0150076 | biological_process | neuroinflammatory response |
| B | 1901136 | biological_process | carbohydrate derivative catabolic process |
Functional Information from PROSITE/UniProt
| site_id | PS00175 |
| Number of Residues | 10 |
| Details | PG_MUTASE Phosphoglycerate mutase family phosphohistidine signature. MlRHGEgAwN |
| Chain | Residue | Details |
| A | MET8-ASN17 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Tele-phosphohistidine intermediate => ECO:0000269|PubMed:17052986 |
| Chain | Residue | Details |
| A | GLY12 | |
| B | GLY12 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:17052986 |
| Chain | Residue | Details |
| A | ARG90 | |
| B | ARG90 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17052986 |
| Chain | Residue | Details |
| A | HIS11 | |
| B | SER63 | |
| B | ARG90 | |
| B | GLU101 | |
| B | ARG117 | |
| B | ASN190 | |
| A | SER24 | |
| A | SER63 | |
| A | ARG90 | |
| A | GLU101 | |
| A | ARG117 | |
| A | ASN190 | |
| B | HIS11 | |
| B | SER24 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 16 |
| Details | SITE: Not glycated => ECO:0000269|PubMed:9832630 |
| Chain | Residue | Details |
| A | LEU30 | |
| B | ALA47 | |
| B | VAL144 | |
| B | THR182 | |
| B | LYS247 | |
| B | VAL248 | |
| B | VAL254 | |
| B | LYS259 | |
| A | ALA47 | |
| A | VAL144 | |
| A | THR182 | |
| A | LYS247 | |
| A | VAL248 | |
| A | VAL254 | |
| A | LYS259 | |
| B | LEU30 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: Transition state stabilizer => ECO:0000269|PubMed:17052986 |
| Chain | Residue | Details |
| A | GLY189 | |
| B | GLY189 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylserine => ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| A | LYS3 | |
| B | LYS3 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | PRO123 | |
| B | PRO123 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 10 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:9832630 |
| Chain | Residue | Details |
| A | TYR4 | |
| B | HIS198 | |
| A | LEU6 | |
| A | GLU19 | |
| A | GLN44 | |
| A | HIS198 | |
| B | TYR4 | |
| B | LEU6 | |
| B | GLU19 | |
| B | GLN44 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:9832630 |
| Chain | Residue | Details |
| A | ASP160 | |
| B | ASP160 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1qhf |
| Chain | Residue | Details |
| A | ARG62 | |
| A | HIS11 | |
| A | GLU89 | |
| A | HIS188 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1qhf |
| Chain | Residue | Details |
| B | ARG62 | |
| B | HIS11 | |
| B | GLU89 | |
| B | HIS188 |
