1T74
Crystal structure of the androgen receptor ligand binding domain in complex with a WxxLF motif
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 300 |
| Chain | Residue |
| A | HOH34 |
| A | SER696 |
| A | PHE697 |
| A | LYS777 |
| A | ARG779 |
| A | SER853 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DHT A 200 |
| Chain | Residue |
| A | MET749 |
| A | ARG752 |
| A | PHE764 |
| A | THR877 |
| A | LEU704 |
| A | ASN705 |
| A | GLN711 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 301 |
| Chain | Residue |
| A | ILE680 |
| A | HIS714 |
| A | SER908 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15328534","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T73","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T76","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T79","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T7F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T7M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T7R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T7T","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Site: {"description":"Interaction with coactivator LXXL and FXXFY motifs","evidences":[{"source":"PubMed","id":"15328534","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Interaction with coactivator FXXLF and FXXFY motifs","evidences":[{"source":"PubMed","id":"15328534","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by CSK","evidences":[{"source":"UniProtKB","id":"P10275","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P10275","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
