Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1T6P

Crystal Structure of Phenylalanine Ammonia Lyase from Rhodosporidium toruloides

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005737	cellular_component	cytoplasm
A	0006559	biological_process	L-phenylalanine catabolic process
A	0009698	biological_process	phenylpropanoid metabolic process
A	0009800	biological_process	cinnamic acid biosynthetic process
A	0016829	molecular_function	lyase activity
A	0016841	molecular_function	ammonia-lyase activity
A	0045548	molecular_function	phenylalanine ammonia-lyase activity
A	0052883	molecular_function	tyrosine ammonia-lyase activity
B	0003824	molecular_function	catalytic activity
B	0005737	cellular_component	cytoplasm
B	0006559	biological_process	L-phenylalanine catabolic process
B	0009698	biological_process	phenylpropanoid metabolic process
B	0009800	biological_process	cinnamic acid biosynthetic process
B	0016829	molecular_function	lyase activity
B	0016841	molecular_function	ammonia-lyase activity
B	0045548	molecular_function	phenylalanine ammonia-lyase activity
B	0052883	molecular_function	tyrosine ammonia-lyase activity
C	0003824	molecular_function	catalytic activity
C	0005737	cellular_component	cytoplasm
C	0006559	biological_process	L-phenylalanine catabolic process
C	0009698	biological_process	phenylpropanoid metabolic process
C	0009800	biological_process	cinnamic acid biosynthetic process
C	0016829	molecular_function	lyase activity
C	0016841	molecular_function	ammonia-lyase activity
C	0045548	molecular_function	phenylalanine ammonia-lyase activity
C	0052883	molecular_function	tyrosine ammonia-lyase activity
D	0003824	molecular_function	catalytic activity
D	0005737	cellular_component	cytoplasm
D	0006559	biological_process	L-phenylalanine catabolic process
D	0009698	biological_process	phenylpropanoid metabolic process
D	0009800	biological_process	cinnamic acid biosynthetic process
D	0016829	molecular_function	lyase activity
D	0016841	molecular_function	ammonia-lyase activity
D	0045548	molecular_function	phenylalanine ammonia-lyase activity
D	0052883	molecular_function	tyrosine ammonia-lyase activity
E	0003824	molecular_function	catalytic activity
E	0005737	cellular_component	cytoplasm
E	0006559	biological_process	L-phenylalanine catabolic process
E	0009698	biological_process	phenylpropanoid metabolic process
E	0009800	biological_process	cinnamic acid biosynthetic process
E	0016829	molecular_function	lyase activity
E	0016841	molecular_function	ammonia-lyase activity
E	0045548	molecular_function	phenylalanine ammonia-lyase activity
E	0052883	molecular_function	tyrosine ammonia-lyase activity
F	0003824	molecular_function	catalytic activity
F	0005737	cellular_component	cytoplasm
F	0006559	biological_process	L-phenylalanine catabolic process
F	0009698	biological_process	phenylpropanoid metabolic process
F	0009800	biological_process	cinnamic acid biosynthetic process
F	0016829	molecular_function	lyase activity
F	0016841	molecular_function	ammonia-lyase activity
F	0045548	molecular_function	phenylalanine ammonia-lyase activity
F	0052883	molecular_function	tyrosine ammonia-lyase activity
G	0003824	molecular_function	catalytic activity
G	0005737	cellular_component	cytoplasm
G	0006559	biological_process	L-phenylalanine catabolic process
G	0009698	biological_process	phenylpropanoid metabolic process
G	0009800	biological_process	cinnamic acid biosynthetic process
G	0016829	molecular_function	lyase activity
G	0016841	molecular_function	ammonia-lyase activity
G	0045548	molecular_function	phenylalanine ammonia-lyase activity
G	0052883	molecular_function	tyrosine ammonia-lyase activity
H	0003824	molecular_function	catalytic activity
H	0005737	cellular_component	cytoplasm
H	0006559	biological_process	L-phenylalanine catabolic process
H	0009698	biological_process	phenylpropanoid metabolic process
H	0009800	biological_process	cinnamic acid biosynthetic process
H	0016829	molecular_function	lyase activity
H	0016841	molecular_function	ammonia-lyase activity
H	0045548	molecular_function	phenylalanine ammonia-lyase activity
H	0052883	molecular_function	tyrosine ammonia-lyase activity

Functional Information from PROSITE/UniProt

site_id	PS00488
Number of Residues	17
Details	PAL_HISTIDASE Phenylalanine and histidine ammonia-lyases signature. GTISASGDLsPLSyiaA

Chain	Residue	Details
A	GLY207-ILE225

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Proton donor/acceptor => ECO:0000250\|UniProtKB:Q68G84

Chain	Residue	Details
A	TYR110
B	TYR110
C	TYR110
D	TYR110
E	TYR110
F	TYR110
G	TYR110
H	TYR110

site_id	SWS_FT_FI2
Number of Residues	40
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q68G84

Chain	Residue	Details
A	THR272
B	ALA501
C	THR272
C	ARG362
C	SER368
C	LEU399
C	ALA501
D	THR272
D	ARG362
D	SER368
D	LEU399
A	ARG362
D	ALA501
E	THR272
E	ARG362
E	SER368
E	LEU399
E	ALA501
F	THR272
F	ARG362
F	SER368
F	LEU399
A	SER368
F	ALA501
G	THR272
G	ARG362
G	SER368
G	LEU399
G	ALA501
H	THR272
H	ARG362
H	SER368
H	LEU399
A	LEU399
H	ALA501
A	ALA501
B	THR272
B	ARG362
B	SER368
B	LEU399

site_id	SWS_FT_FI3
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:15350127, ECO:0007744\|PDB:1T6J

Chain	Residue	Details
A	LEU470
E	ALA498
F	LEU470
F	ALA498
G	LEU470
G	ALA498
H	LEU470
H	ALA498
A	ALA498
B	LEU470
B	ALA498
C	LEU470
C	ALA498
D	LEU470
D	ALA498
E	LEU470

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: 2,3-didehydroalanine (Ser) => ECO:0000269\|PubMed:15350127

Chain	Residue	Details
A	ASP214
B	ASP214
C	ASP214
D	ASP214
E	ASP214
F	ASP214
G	ASP214
H	ASP214

site_id	SWS_FT_FI5
Number of Residues	16
Details	CROSSLNK: 5-imidazolinone (Ala-Gly) => ECO:0000269\|PubMed:15350127

Chain	Residue	Details
A	175211
E	LEU215
F	175211
F	LEU215
G	175211
G	LEU215
H	175211
H	LEU215
A	LEU215
B	175211
B	LEU215
C	175211
C	LEU215
D	175211
D	LEU215
E	175211

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)