1T6M

X-ray Structure of the R70D PI-PLC enzyme: Insight into the role of calcium and surrounding amino acids on active site geometry and catalysis.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004436	molecular_function	phosphatidylinositol diacylglycerol-lyase activity
A	0005576	cellular_component	extracellular region
A	0006629	biological_process	lipid metabolic process
A	0008081	molecular_function	phosphoric diester hydrolase activity
A	0016042	biological_process	lipid catabolic process
A	0016829	molecular_function	lyase activity
B	0004436	molecular_function	phosphatidylinositol diacylglycerol-lyase activity
B	0005576	cellular_component	extracellular region
B	0006629	biological_process	lipid metabolic process
B	0008081	molecular_function	phosphoric diester hydrolase activity
B	0016042	biological_process	lipid catabolic process
B	0016829	molecular_function	lyase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 501

Chain	Residue
A	ASP228
A	ASN230
A	HIS231
A	HOH546

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 502

Chain	Residue
A	ASP37
A	ASP73
A	HOH503
A	HOH549

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA B 503

Chain	Residue
B	ASP73
B	HOH554
B	ASP37

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA B 504

Chain	Residue
B	ASP228
B	ASN230

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	286
Details	Domain: {"description":"PI-PLC X-box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00270","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00270","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00270","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---