1T60
Crystal structure of Type IV collagen NC1 domain from bovine lens capsule
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005201 | molecular_function | extracellular matrix structural constituent |
| A | 0005581 | cellular_component | collagen trimer |
| B | 0005201 | molecular_function | extracellular matrix structural constituent |
| B | 0005581 | cellular_component | collagen trimer |
| C | 0005201 | molecular_function | extracellular matrix structural constituent |
| C | 0005581 | cellular_component | collagen trimer |
| C | 0005604 | cellular_component | basement membrane |
| C | 0030199 | biological_process | collagen fibril organization |
| D | 0005201 | molecular_function | extracellular matrix structural constituent |
| D | 0005581 | cellular_component | collagen trimer |
| E | 0005201 | molecular_function | extracellular matrix structural constituent |
| E | 0005581 | cellular_component | collagen trimer |
| F | 0005201 | molecular_function | extracellular matrix structural constituent |
| F | 0005581 | cellular_component | collagen trimer |
| F | 0005604 | cellular_component | basement membrane |
| F | 0030199 | biological_process | collagen fibril organization |
| G | 0005201 | molecular_function | extracellular matrix structural constituent |
| G | 0005581 | cellular_component | collagen trimer |
| H | 0005201 | molecular_function | extracellular matrix structural constituent |
| H | 0005581 | cellular_component | collagen trimer |
| I | 0005201 | molecular_function | extracellular matrix structural constituent |
| I | 0005581 | cellular_component | collagen trimer |
| I | 0005604 | cellular_component | basement membrane |
| I | 0030199 | biological_process | collagen fibril organization |
| J | 0005201 | molecular_function | extracellular matrix structural constituent |
| J | 0005581 | cellular_component | collagen trimer |
| K | 0005201 | molecular_function | extracellular matrix structural constituent |
| K | 0005581 | cellular_component | collagen trimer |
| L | 0005201 | molecular_function | extracellular matrix structural constituent |
| L | 0005581 | cellular_component | collagen trimer |
| L | 0005604 | cellular_component | basement membrane |
| L | 0030199 | biological_process | collagen fibril organization |
| M | 0005201 | molecular_function | extracellular matrix structural constituent |
| M | 0005581 | cellular_component | collagen trimer |
| N | 0005201 | molecular_function | extracellular matrix structural constituent |
| N | 0005581 | cellular_component | collagen trimer |
| O | 0005201 | molecular_function | extracellular matrix structural constituent |
| O | 0005581 | cellular_component | collagen trimer |
| O | 0005604 | cellular_component | basement membrane |
| O | 0030199 | biological_process | collagen fibril organization |
| P | 0005201 | molecular_function | extracellular matrix structural constituent |
| P | 0005581 | cellular_component | collagen trimer |
| Q | 0005201 | molecular_function | extracellular matrix structural constituent |
| Q | 0005581 | cellular_component | collagen trimer |
| R | 0005201 | molecular_function | extracellular matrix structural constituent |
| R | 0005581 | cellular_component | collagen trimer |
| R | 0005604 | cellular_component | basement membrane |
| R | 0030199 | biological_process | collagen fibril organization |
| S | 0005201 | molecular_function | extracellular matrix structural constituent |
| S | 0005581 | cellular_component | collagen trimer |
| T | 0005201 | molecular_function | extracellular matrix structural constituent |
| T | 0005581 | cellular_component | collagen trimer |
| U | 0005201 | molecular_function | extracellular matrix structural constituent |
| U | 0005581 | cellular_component | collagen trimer |
| U | 0005604 | cellular_component | basement membrane |
| U | 0030199 | biological_process | collagen fibril organization |
| V | 0005201 | molecular_function | extracellular matrix structural constituent |
| V | 0005581 | cellular_component | collagen trimer |
| W | 0005201 | molecular_function | extracellular matrix structural constituent |
| W | 0005581 | cellular_component | collagen trimer |
| X | 0005201 | molecular_function | extracellular matrix structural constituent |
| X | 0005581 | cellular_component | collagen trimer |
| X | 0005604 | cellular_component | basement membrane |
| X | 0030199 | biological_process | collagen fibril organization |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K C 5101 |
| Chain | Residue |
| A | TYR189 |
| C | TYR63 |
| C | ASN65 |
| E | ALA186 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K D 5102 |
| Chain | Residue |
| B | ALA186 |
| D | TYR189 |
| F | TYR63 |
| F | ASN65 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K G 5103 |
| Chain | Residue |
| I | TYR63 |
| I | ASN65 |
| K | ALA186 |
| G | TYR189 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K L 5104 |
| Chain | Residue |
| H | ALA186 |
| J | TYR189 |
| L | TYR63 |
| L | ASN65 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K M 5105 |
| Chain | Residue |
| M | TYR189 |
| O | TYR63 |
| O | ASN65 |
| Q | ALA186 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K P 5106 |
| Chain | Residue |
| N | ALA186 |
| P | TYR189 |
| R | TYR63 |
| R | ASN65 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K U 5107 |
| Chain | Residue |
| S | TYR189 |
| U | TYR63 |
| U | ASN65 |
| W | ALA186 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K V 5108 |
| Chain | Residue |
| T | ALA186 |
| V | TYR189 |
| X | TYR63 |
| X | ASN65 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K B 5109 |
| Chain | Residue |
| B | ASN66 |
| B | HOH5142 |
| C | TYR187 |
| F | TYR183 |
| F | ALA184 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K C 5110 |
| Chain | Residue |
| C | TYR183 |
| C | ALA184 |
| E | ASN66 |
| F | TYR187 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K H 5111 |
| Chain | Residue |
| H | ASN66 |
| H | HOH5152 |
| I | TYR187 |
| L | TYR183 |
| L | ALA184 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K I 5112 |
| Chain | Residue |
| I | ALA184 |
| K | ASN66 |
| K | HOH294 |
| L | TYR187 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE K N 5113 |
| Chain | Residue |
| N | ASN66 |
| O | TYR187 |
| R | ALA184 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K O 5114 |
| Chain | Residue |
| O | TYR183 |
| O | ALA184 |
| Q | ASN66 |
| R | TYR187 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K T 5115 |
| Chain | Residue |
| T | ASN66 |
| U | TYR187 |
| X | TYR183 |
| X | ALA184 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K U 5116 |
| Chain | Residue |
| U | TYR183 |
| U | ALA184 |
| W | ASN66 |
| X | TYR187 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 5201 |
| Chain | Residue |
| A | ALA74 |
| A | ARG76 |
| A | ASP78 |
| A | HOH5203 |
| D | HOH5256 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL C 5202 |
| Chain | Residue |
| C | ALA73 |
| C | ARG75 |
| C | ASN76 |
| C | ASP77 |
| C | HOH5209 |
| C | HOH5221 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL D 5203 |
| Chain | Residue |
| A | HOH5246 |
| D | ALA74 |
| D | ARG76 |
| D | ASN77 |
| D | ASP78 |
| D | HOH5211 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL F 5204 |
| Chain | Residue |
| F | ALA73 |
| F | ARG75 |
| F | ASP77 |
| F | HOH5224 |
| F | HOH5225 |
| site_id | CC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL G 5205 |
| Chain | Residue |
| G | ALA74 |
| G | ARG76 |
| G | ASP78 |
| G | GLY178 |
| G | HOH5215 |
| J | ARG179 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL I 5206 |
| Chain | Residue |
| I | ALA73 |
| I | ARG75 |
| I | ASN76 |
| I | ASP77 |
| I | HOH5211 |
| site_id | CC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CL J 5207 |
| Chain | Residue |
| J | ALA74 |
| J | ARG76 |
| J | ASN77 |
| J | ASP78 |
| J | GLY178 |
| J | HOH5216 |
| G | ARG179 |
| site_id | CC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL M 5208 |
| Chain | Residue |
| M | ALA74 |
| M | ARG76 |
| M | ASP78 |
| M | GLY178 |
| M | HOH5217 |
| P | HOH5251 |
| site_id | CC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL L 5209 |
| Chain | Residue |
| L | ALA73 |
| L | ARG75 |
| L | ASN76 |
| L | ASP77 |
| L | HOH5216 |
| L | HOH5229 |
| site_id | CC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CL O 5210 |
| Chain | Residue |
| O | ALA73 |
| O | SER74 |
| O | ARG75 |
| O | ASN76 |
| O | ASP77 |
| O | HOH5213 |
| O | HOH5232 |
| site_id | CC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CL P 5211 |
| Chain | Residue |
| M | HOH5248 |
| P | ALA74 |
| P | ARG76 |
| P | ASN77 |
| P | ASP78 |
| P | GLY178 |
| P | HOH5230 |
| site_id | DC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL R 5212 |
| Chain | Residue |
| R | ALA73 |
| R | ARG75 |
| R | ASN76 |
| R | ASP77 |
| R | HOH5225 |
| site_id | DC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CL S 5213 |
| Chain | Residue |
| S | ALA74 |
| S | ARG76 |
| S | ASN77 |
| S | ASP78 |
| S | GLY178 |
| S | HOH5230 |
| V | ARG179 |
| site_id | DC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL U 5214 |
| Chain | Residue |
| U | ALA73 |
| U | ARG75 |
| U | ASN76 |
| U | ASP77 |
| U | HOH5219 |
| U | HOH5235 |
| site_id | DC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL V 5215 |
| Chain | Residue |
| V | ALA74 |
| V | ARG76 |
| V | ASP78 |
| site_id | DC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL X 5216 |
| Chain | Residue |
| X | ALA73 |
| X | ARG75 |
| X | ASN76 |
| X | ASP77 |
| X | HOH5242 |
| site_id | DC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MPD A 5001 |
| Chain | Residue |
| A | HIS121 |
| A | GLN129 |
| A | PRO131 |
| site_id | DC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MPD T 5002 |
| Chain | Residue |
| T | GLY23 |
| T | LYS25 |
| T | GLU112 |
| site_id | DC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MPD M 5003 |
| Chain | Residue |
| M | HIS121 |
| M | GLN129 |
| M | HOH5316 |
| site_id | DC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MPD S 5004 |
| Chain | Residue |
| S | VAL120 |
| S | GLN129 |
| S | PRO131 |
| site_id | EC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MPD S 5005 |
| Chain | Residue |
| S | PHE168 |
| S | ALA212 |
| S | GLY213 |
| S | LEU215 |
| S | ARG216 |
| U | HOH5285 |
| site_id | EC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MPD P 5006 |
| Chain | Residue |
| P | VAL120 |
| P | GLN129 |
| R | LEU26 |
| R | TRP27 |
| site_id | EC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MPD D 5007 |
| Chain | Residue |
| D | MET89 |
| D | MET93 |
| D | TYR185 |
| D | ALA186 |
| D | HOH5262 |
| F | PRO66 |
| F | GLY67 |
| site_id | EC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MPD M 5008 |
| Chain | Residue |
| M | MET89 |
| M | MET93 |
| M | ALA186 |
| M | HOH5254 |
| O | GLY67 |
| P | ASN68 |
| site_id | EC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MPD J 5009 |
| Chain | Residue |
| G | ASN68 |
| J | MET89 |
| J | MET93 |
| J | TYR185 |
| J | ALA186 |
| L | PRO66 |
| L | GLY67 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | Cross-link: {"description":"S-Lysyl-methionine sulfilimine (Met-Lys) (interchain with K-1651)","evidences":[{"source":"PubMed","id":"19729652","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | Cross-link: {"description":"S-Lysyl-methionine sulfilimine (Lys-Met) (interchain with M-1533)","evidences":[{"source":"PubMed","id":"19729652","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 672 |
| Details | Domain: {"description":"Collagen IV NC1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00736","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
